YDL075W / RPL31A

Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL075W / RPL31A

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.81|P-value:3.94E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-4.80|P-value:1.18E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:4.09|P-value:1.69E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.79|P-value:1.90E-7 ID:SGTC_123|Compound:0083-0120|FD-Score:4.68|P-value:2.05E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.90|P-value:3.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.98|P-value:2.30E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.08|P-value:3.91E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.30|P-value:1.64E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.51|P-value:6.37E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:4.00|P-value:2.27E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.87|P-value:3.47E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:4.25|P-value:9.74E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.77|P-value:4.73E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.94|P-value:2.75E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.67|P-value:6.25E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:5.27|P-value:1.89E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:-5.40|P-value:1.04E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.71|P-value:5.76E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.16|P-value:1.34E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.98|P-value:2.40E-4 ID:SGTC_1642|Compound:st009582|FD-Score:-3.58|P-value:8.19E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.90|P-value:3.14E-4 ID:SGTC_1808|Compound:st050063|FD-Score:4.27|P-value:9.11E-5 ID:SGTC_1867|Compound:st057372|FD-Score:6.48|P-value:6.66E-9 ID:SGTC_1876|Compound:myriocin|FD-Score:3.97|P-value:2.50E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.66|P-value:6.62E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.63|P-value:2.43E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-5.24|P-value:1.98E-6 ID:SGTC_2208|Compound:7283366|FD-Score:-3.81|P-value:4.02E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.58|P-value:8.46E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-4.45|P-value:4.47E-5 ID:SGTC_2278|Compound:7948257|FD-Score:-3.53|P-value:9.42E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.76|P-value:1.52E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.53|P-value:9.86E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.78|P-value:4.58E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.15|P-value:1.32E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.65|P-value:2.17E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.98|P-value:2.47E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-4.19|P-value:1.13E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.69|P-value:5.77E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.88|P-value:8.63E-6 ID:SGTC_2873|Compound:9040596|FD-Score:-6.34|P-value:1.26E-8 ID:SGTC_2996|Compound:9066192|FD-Score:4.48|P-value:4.30E-5 ID:SGTC_3135|Compound:9127742|FD-Score:4.22|P-value:1.09E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.64|P-value:6.76E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-3.60|P-value:7.60E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.81|P-value:3.94E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-4.80|P-value:1.18E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:4.09|P-value:1.69E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.79|P-value:1.90E-7 ID:SGTC_123|Compound:0083-0120|FD-Score:4.68|P-value:2.05E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.90|P-value:3.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.98|P-value:2.30E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.08|P-value:3.91E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:6.30|P-value:1.64E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.51|P-value:6.37E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:4.00|P-value:2.27E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.87|P-value:3.47E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:4.25|P-value:9.74E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.77|P-value:4.73E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.94|P-value:2.75E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.67|P-value:6.25E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:5.27|P-value:1.89E-6 ID:SGTC_1356|Compound:1502-0781|FD-Score:-5.40|P-value:1.04E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.71|P-value:5.76E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.16|P-value:1.34E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.98|P-value:2.40E-4 ID:SGTC_1642|Compound:st009582|FD-Score:-3.58|P-value:8.19E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.90|P-value:3.14E-4 ID:SGTC_1808|Compound:st050063|FD-Score:4.27|P-value:9.11E-5 ID:SGTC_1867|Compound:st057372|FD-Score:6.48|P-value:6.66E-9 ID:SGTC_1876|Compound:myriocin|FD-Score:3.97|P-value:2.50E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.66|P-value:6.62E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.63|P-value:2.43E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-5.24|P-value:1.98E-6 ID:SGTC_2208|Compound:7283366|FD-Score:-3.81|P-value:4.02E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.58|P-value:8.46E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-4.45|P-value:4.47E-5 ID:SGTC_2278|Compound:7948257|FD-Score:-3.53|P-value:9.42E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.76|P-value:1.52E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.53|P-value:9.86E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.78|P-value:4.58E-4 ID:SGTC_2350|Compound:9023895|FD-Score:-4.15|P-value:1.32E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.65|P-value:2.17E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.98|P-value:2.47E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-4.19|P-value:1.13E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.69|P-value:5.77E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.88|P-value:8.63E-6 ID:SGTC_2873|Compound:9040596|FD-Score:-6.34|P-value:1.26E-8 ID:SGTC_2996|Compound:9066192|FD-Score:4.48|P-value:4.30E-5 ID:SGTC_3135|Compound:9127742|FD-Score:4.22|P-value:1.09E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.64|P-value:6.76E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-3.60|P-value:7.60E-4

Top fitness defect scores for YDL075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1867 st057372 6.48 64.0 µM 6.66E-9 1 4.64E-11
2 SGTC_451 chloral hydrate 6.30 100.0 µM 1.64E-8 13 1.48E-10
3 SGTC_118 0083-0097 5.79 135.3 µM 1.90E-7 translation 29 3.49E-9
4 SGTC_1354 1498-1681 5.27 81.0 µM 1.89E-6 4 6.73E-8
5 SGTC_2293 7624732 4.76 200.0 µM 1.52E-5 11 9.78E-7
6 SGTC_123 0083-0120 4.68 66.7 µM 2.05E-5 29 1.44E-6
7 SGTC_2012 4023501 4.63 200.0 µM 2.43E-5 18 1.79E-6
8 SGTC_2996 9066192 4.48 71.4 µM 4.30E-5 20 3.73E-6
9 SGTC_1808 st050063 4.27 61.5 µM 9.11E-5 7 9.77E-6
10 SGTC_956 1185-0240 4.25 191.0 µM 9.74E-5 15 1.06E-5
11 SGTC_3135 9127742 4.22 49.5 µM 1.09E-4 15 1.22E-5
12 SGTC_1502 4534-4282 4.16 27.7 µM 1.34E-4 8 1.60E-5
13 SGTC_51 1013-0126 4.09 23.4 µM 1.69E-4 27 2.15E-5
14 SGTC_881 0833-0569 4.00 170.0 µM 2.27E-4 27 3.15E-5
15 SGTC_1631 benzylvanillin 3.98 81.9 µM 2.40E-4 Golgi 28 3.37E-5
16 SGTC_2660 2',4'-dihydroxychalcone 3.98 17.1 µM 2.47E-4 18 3.50E-5
17 SGTC_1876 myriocin 3.97 605.0 nM 2.50E-4 31 3.56E-5
18 SGTC_1189 1431-2119 3.94 7.3 µM 2.75E-4 27 4.02E-5
19 SGTC_1648 st011736 3.90 69.8 µM 3.14E-4 PDR1 16 4.77E-5
20 SGTC_177 1327-0068 3.90 8.4 µM 3.21E-4 42 4.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.12E-11 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.107 4.87E-10 YBR017C KAP104 hom Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis
0.107 5.71E-10 YHR010W RPL27A hom Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication
0.107 5.88E-10 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.104 1.61E-9 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
0.103 1.84E-9 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.101 3.96E-9 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.099 7.87E-9 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.097 2.11E-8 YGL076C RPL7A hom Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication
0.096 2.21E-8 YKR092C SRP40 hom Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
0.096 2.30E-8 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.096 2.38E-8 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.092 8.20E-8 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.092 9.94E-8 YDR484W VPS52 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
0.090 1.85E-7 YLR182W SWI6 hom Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators