YDL078C / MDH3

Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL078C / MDH3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.32|P-value:1.84E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.24|P-value:2.56E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.33|P-value:1.73E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.36|P-value:7.95E-7 ID:SGTC_152|Compound:4469-0003|FD-Score:2.96|P-value:5.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.37|P-value:1.01E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.52|P-value:5.24E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:2.90|P-value:6.64E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:2.90|P-value:6.80E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.92|P-value:6.23E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.16|P-value:3.44E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.39|P-value:1.34E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.35|P-value:8.48E-7 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.13|P-value:2.72E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.87|P-value:7.46E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.52|P-value:5.10E-5 ID:SGTC_1634|Compound:st006576|FD-Score:2.90|P-value:6.61E-4 ID:SGTC_1662|Compound:st014054|FD-Score:-3.05|P-value:5.43E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-2.90|P-value:9.51E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.61|P-value:3.41E-5 ID:SGTC_1746|Compound:st038117|FD-Score:2.89|P-value:6.97E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.90|P-value:6.71E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.43|P-value:1.16E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.94|P-value:1.09E-5 ID:SGTC_2054|Compound:5233173|FD-Score:2.81|P-value:9.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.80|P-value:2.17E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.83|P-value:8.68E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.72|P-value:1.03E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.90|P-value:1.34E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.23|P-value:2.64E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.94|P-value:5.85E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.38|P-value:9.45E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.19|P-value:1.97E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.14|P-value:2.63E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.11|P-value:3.00E-4 ID:SGTC_2880|Compound:9042983|FD-Score:5.01|P-value:1.79E-8 ID:SGTC_2944|Compound:9067346|FD-Score:-3.83|P-value:1.91E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.63|P-value:2.93E-7 ID:SGTC_2980|Compound:9014342|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.34|P-value:1.64E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.83|P-value:1.21E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.28|P-value:2.02E-6 ID:SGTC_3224|Compound:9130643|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.16|P-value:2.38E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.32|P-value:1.84E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.24|P-value:2.56E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.33|P-value:1.73E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.36|P-value:7.95E-7 ID:SGTC_152|Compound:4469-0003|FD-Score:2.96|P-value:5.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.37|P-value:1.01E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.52|P-value:5.24E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:2.90|P-value:6.64E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:2.90|P-value:6.80E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.92|P-value:6.23E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.16|P-value:3.44E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.39|P-value:1.34E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.35|P-value:8.48E-7 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.13|P-value:2.72E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.87|P-value:7.46E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.52|P-value:5.10E-5 ID:SGTC_1634|Compound:st006576|FD-Score:2.90|P-value:6.61E-4 ID:SGTC_1662|Compound:st014054|FD-Score:-3.05|P-value:5.43E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-2.90|P-value:9.51E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.61|P-value:3.41E-5 ID:SGTC_1746|Compound:st038117|FD-Score:2.89|P-value:6.97E-4 ID:SGTC_1779|Compound:st039427|FD-Score:2.90|P-value:6.71E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.43|P-value:1.16E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.94|P-value:1.09E-5 ID:SGTC_2054|Compound:5233173|FD-Score:2.81|P-value:9.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.80|P-value:2.17E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.83|P-value:8.68E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.72|P-value:1.03E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.90|P-value:1.34E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.23|P-value:2.64E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.94|P-value:5.85E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.38|P-value:9.45E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.19|P-value:1.97E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.14|P-value:2.63E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.11|P-value:3.00E-4 ID:SGTC_2880|Compound:9042983|FD-Score:5.01|P-value:1.79E-8 ID:SGTC_2944|Compound:9067346|FD-Score:-3.83|P-value:1.91E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.63|P-value:2.93E-7 ID:SGTC_2980|Compound:9014342|FD-Score:3.20|P-value:2.08E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.34|P-value:1.64E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.83|P-value:1.21E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.28|P-value:2.02E-6 ID:SGTC_3224|Compound:9130643|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.16|P-value:2.38E-4

Top fitness defect scores for YDL078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2880 9042983 5.01 58.4 µM 1.79E-8 fatty acid desaturase (OLE1) 9 2.67E-7
2 SGTC_2583 asiatic acid 4.72 100.0 µM 1.03E-7 23 1.16E-6
3 SGTC_151 3013-0144 4.36 2.3 µM 7.95E-7 iron homeostasis 19 6.46E-6
4 SGTC_1239 0337-0584 4.35 35.4 µM 8.48E-7 unfolded protein response 44 6.81E-6
5 SGTC_2816 7982706 4.19 58.4 µM 1.97E-6 azole & statin 44 1.39E-5
6 SGTC_3156 9099931 3.83 49.5 µM 1.21E-5 9 6.38E-5
7 SGTC_1738 st035555 3.61 74.0 µM 3.41E-5 TSC3-RPN4 45 1.52E-4
8 SGTC_1548 st061468 3.52 90.8 µM 5.10E-5 17 2.14E-4
9 SGTC_549 1661-1316 3.52 519.0 µM 5.24E-5 26 2.19E-4
10 SGTC_2810 7959871 3.38 45.5 µM 9.45E-5 copper-dependent oxidative stress 62 3.59E-4
11 SGTC_310 1273-0058 3.37 1.1 µM 1.01E-4 mitochondrial stress 305 3.81E-4
12 SGTC_3224 9130643 3.33 49.5 µM 1.17E-4 RPP1 & pyrimidine depletion 52 4.31E-4
13 SGTC_2980 9014342 3.20 25.3 µM 2.08E-4 69 6.98E-4
14 SGTC_3326 9140064 3.16 16.4 µM 2.38E-4 44 7.81E-4
15 SGTC_2838 9002687 3.14 71.4 µM 2.63E-4 fatty acid desaturase (OLE1) 56 8.51E-4
16 SGTC_1537 2',6'-dihydroxyflavanone 3.13 78.0 µM 2.72E-4 48 8.76E-4
17 SGTC_2845 9003024 3.11 43.0 µM 3.00E-4 amide catabolism 83 9.49E-4
18 SGTC_689 0833-0039 3.10 98.0 µM 3.09E-4 ergosterol depletion effects on membrane 58 9.75E-4
19 SGTC_152 4469-0003 2.96 551.2 µM 5.29E-4 55 0.00153
20 SGTC_2690 usnic acid 2.94 100.0 µM 5.85E-4 83 0.00167

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.91E-25 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.166 4.97E-22 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.162 3.74E-21 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.138 9.04E-16 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.137 1.72E-15 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.131 2.16E-14 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.125 3.44E-13 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.120 2.99E-12 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.120 3.34E-12 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.120 3.49E-12 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.119 3.72E-12 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.119 4.04E-12 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.114 3.12E-11 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.114 3.88E-11 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.112 6.58E-11 YMR147W_p YMR147W_p hom Putative protein of unknown function