YDL081C / RPP1A

Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL081C / RPP1A

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:3.08|P-value:8.91E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.88|P-value:4.22E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.06|P-value:9.94E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.16|P-value:6.80E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.52|P-value:1.88E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.07|P-value:9.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.24|P-value:5.31E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.37|P-value:4.59E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:7.57|P-value:8.17E-15 ID:SGTC_366|Compound:0181-0206|FD-Score:3.48|P-value:2.11E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.87|P-value:4.59E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.65|P-value:1.08E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.21|P-value:5.71E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.49|P-value:2.01E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.21|P-value:9.76E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.59|P-value:1.34E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.36|P-value:3.30E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.07|P-value:1.79E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.59|P-value:1.60E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.14|P-value:7.28E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.25|P-value:4.90E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.70|P-value:8.63E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.32|P-value:3.98E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.21|P-value:5.65E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.09|P-value:8.69E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.26|P-value:4.70E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.26|P-value:4.76E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.10|P-value:8.33E-4 ID:SGTC_2313|Compound:7726885|FD-Score:6.80|P-value:2.83E-12 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.51|P-value:1.95E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.73|P-value:7.67E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.70|P-value:9.28E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.17|P-value:1.18E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.01|P-value:1.86E-7 ID:SGTC_2701|Compound:st077767|FD-Score:-3.10|P-value:8.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.12|P-value:7.61E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.30|P-value:4.31E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.31|P-value:3.88E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.09|P-value:1.67E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.94|P-value:3.42E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.08|P-value:8.91E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.88|P-value:4.22E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.06|P-value:9.94E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.16|P-value:6.80E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.52|P-value:1.88E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.07|P-value:9.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.24|P-value:5.31E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.37|P-value:4.59E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:7.57|P-value:8.17E-15 ID:SGTC_366|Compound:0181-0206|FD-Score:3.48|P-value:2.11E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.87|P-value:4.59E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:3.65|P-value:1.08E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.21|P-value:5.71E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.49|P-value:2.01E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.21|P-value:9.76E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.59|P-value:1.34E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.17|P-value:1.20E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.36|P-value:3.30E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.07|P-value:1.79E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.59|P-value:1.60E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.14|P-value:7.28E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.25|P-value:4.90E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.70|P-value:8.63E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.32|P-value:3.98E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.21|P-value:5.65E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.09|P-value:8.69E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.26|P-value:4.70E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.26|P-value:4.76E-4 ID:SGTC_2195|Compound:6536160|FD-Score:3.10|P-value:8.33E-4 ID:SGTC_2313|Compound:7726885|FD-Score:6.80|P-value:2.83E-12 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.51|P-value:1.95E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.73|P-value:7.67E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.70|P-value:9.28E-7 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.17|P-value:1.18E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.01|P-value:1.86E-7 ID:SGTC_2701|Compound:st077767|FD-Score:-3.10|P-value:8.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.12|P-value:7.61E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.30|P-value:4.31E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.31|P-value:3.88E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.09|P-value:1.67E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.94|P-value:3.42E-5

Top fitness defect scores for YDL081C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_364 0083-0097 7.57 67.7 µM 8.17E-15 3 1.81E-14
2 SGTC_2313 7726885 6.80 200.0 µM 2.83E-12 RPP1 & pyrimidine depletion 1 5.39E-12
3 SGTC_2688 kanamycin b 5.01 96.7 µM 1.86E-7 calcium & mitochondrial duress 243 2.68E-7
4 SGTC_2555 cholic acid 4.70 100.0 µM 9.28E-7 9 1.28E-6
5 SGTC_1512 0259-0544 4.59 12.2 µM 1.60E-6 7 2.18E-6
6 SGTC_361 000s-0510 4.37 1.4 µM 4.59E-6 25 6.10E-6
7 SGTC_786 4544-0069 4.21 423.0 µM 9.76E-6 19 1.27E-5
8 SGTC_2560 caryophyllene 4.17 100.0 µM 1.18E-5 13 1.53E-5
9 SGTC_887 0885-0007 4.17 9.6 µM 1.20E-5 endomembrane recycling 32 1.55E-5
10 SGTC_3260 9137109 4.09 49.5 µM 1.67E-5 60S ribosome export 10 2.15E-5
11 SGTC_1360 1598-0022 4.07 39.8 µM 1.79E-5 ERG2 25 2.30E-5
12 SGTC_118 0083-0097 3.88 135.3 µM 4.22E-5 translation 142 5.30E-5
13 SGTC_2410 aloe-emodin-8-o-glycoside 3.73 46.3 µM 7.67E-5 mitochondrial processes 40 9.49E-5
14 SGTC_1528 arabinosylhypoxanthine 3.70 74.6 µM 8.63E-5 30 1.07E-4
15 SGTC_542 3381-0244 3.65 89.3 µM 1.08E-4 50 1.32E-4
16 SGTC_782 0083-0095 3.60 30.5 µM 1.31E-4 45 1.60E-4
17 SGTC_234 nsc-17383 3.60 10.7 µM 1.32E-4 ERG2 30 1.61E-4
18 SGTC_791 1348-1292 3.59 225.0 µM 1.34E-4 47 1.63E-4
19 SGTC_625 k213-0058 3.49 121.0 µM 2.01E-4 translation 149 2.42E-4
20 SGTC_366 0181-0206 3.48 4.3 µM 2.11E-4 Golgi 58 2.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.274 9.97E-59 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.200 1.76E-31 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.172 1.32E-23 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.149 3.39E-18 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.147 8.87E-18 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.142 1.31E-16 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 3.08E-16 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.136 2.38E-15 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.133 1.01E-14 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.131 2.22E-14 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.130 4.68E-14 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.127 1.39E-13 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.127 1.49E-13 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.126 2.21E-13 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.126 2.67E-13 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation