YDL087C / LUC7

Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL087C / LUC7

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:4.21|P-value:2.70E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.50|P-value:3.99E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.00|P-value:6.17E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.33|P-value:7.04E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.43|P-value:1.07E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.73|P-value:1.73E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.28|P-value:7.78E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.39|P-value:5.71E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.35|P-value:1.49E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.31|P-value:7.56E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.64|P-value:2.38E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.00|P-value:6.19E-5 ID:SGTC_1864|Compound:st057645|FD-Score:3.32|P-value:7.32E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-4.46|P-value:8.87E-6 ID:SGTC_1949|Compound:st076024|FD-Score:-4.70|P-value:3.04E-6 ID:SGTC_2034|Compound:5197015|FD-Score:4.88|P-value:1.41E-6 ID:SGTC_2046|Compound:4110841|FD-Score:5.23|P-value:2.67E-7 ID:SGTC_2097|Compound:5376186|FD-Score:-4.99|P-value:7.77E-7 ID:SGTC_2101|Compound:5377231|FD-Score:-5.75|P-value:1.57E-8 ID:SGTC_2102|Compound:5377816|FD-Score:-3.80|P-value:1.24E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.19|P-value:2.95E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.42|P-value:5.32E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.46|P-value:4.59E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.11|P-value:3.98E-5 ID:SGTC_2478|Compound:5763493|FD-Score:4.25|P-value:2.27E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.90|P-value:9.16E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.40|P-value:1.21E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.59|P-value:2.87E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.75|P-value:1.54E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.59|P-value:2.86E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.93|P-value:7.77E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-3.35|P-value:6.30E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:4.21|P-value:2.70E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.50|P-value:3.99E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.00|P-value:6.17E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.33|P-value:7.04E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.43|P-value:1.07E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.73|P-value:1.73E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.28|P-value:7.78E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.39|P-value:5.71E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.35|P-value:1.49E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.31|P-value:7.56E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.64|P-value:2.38E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.00|P-value:6.19E-5 ID:SGTC_1864|Compound:st057645|FD-Score:3.32|P-value:7.32E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-4.46|P-value:8.87E-6 ID:SGTC_1949|Compound:st076024|FD-Score:-4.70|P-value:3.04E-6 ID:SGTC_2034|Compound:5197015|FD-Score:4.88|P-value:1.41E-6 ID:SGTC_2046|Compound:4110841|FD-Score:5.23|P-value:2.67E-7 ID:SGTC_2097|Compound:5376186|FD-Score:-4.99|P-value:7.77E-7 ID:SGTC_2101|Compound:5377231|FD-Score:-5.75|P-value:1.57E-8 ID:SGTC_2102|Compound:5377816|FD-Score:-3.80|P-value:1.24E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.19|P-value:2.95E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.42|P-value:5.32E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.46|P-value:4.59E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.11|P-value:3.98E-5 ID:SGTC_2478|Compound:5763493|FD-Score:4.25|P-value:2.27E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.90|P-value:9.16E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.40|P-value:1.21E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.59|P-value:2.87E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.75|P-value:1.54E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.59|P-value:2.86E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.93|P-value:7.77E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-3.35|P-value:6.30E-4

Top fitness defect scores for YDL087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2046 4110841 5.23 106.0 µM 2.67E-7 iron homeostasis 5 8.66E-8 0.84
2 SGTC_2034 5197015 4.88 53.1 µM 1.41E-6 SWF1 & branched chain AA biosynthesis 1 5.23E-7 1.36
3 SGTC_847 0342-0274 4.43 5.5 µM 1.07E-5 2 4.69E-6 0.54
4 SGTC_2572 astragaloside iv 4.40 100.0 µM 1.21E-5 3 5.35E-6 0.15
5 SGTC_1401 3807-4679 4.35 7.6 µM 1.49E-5 tubulin folding & SWR complex 2 6.68E-6 0.13
6 SGTC_2478 5763493 4.25 32.3 µM 2.27E-5 4 1.06E-5 0.41
7 SGTC_62 0180-0423 4.21 3.2 µM 2.70E-5 60S ribosome export 8 1.28E-5 0.04
8 SGTC_2178 5812956 4.19 200.0 µM 2.95E-5 3 1.40E-5 0.43
9 SGTC_2427 5545055 4.11 42.8 µM 3.98E-5 6 1.94E-5 0.09
10 SGTC_574 1315-0397 4.00 40.0 µM 6.17E-5 9 3.11E-5 0.06
11 SGTC_1838 st055369 4.00 84.5 µM 6.19E-5 7 3.13E-5 0.20
12 SGTC_2571 chrysanthemic acid 3.90 100.0 µM 9.16E-5 6 4.77E-5 0.13
13 SGTC_856 0433-0016 3.73 11.3 µM 1.73E-4 3 9.51E-5 0.10
14 SGTC_2344 7990960 3.67 77.0 µM 2.21E-4 43 1.23E-4 0.02
15 SGTC_1801 st050089 3.64 28.4 µM 2.38E-4 NEO1-PIK1 14 1.34E-4 0.13
16 SGTC_2944 9067346 3.59 25.6 µM 2.86E-4 17 1.63E-4 0.36
17 SGTC_2900 5328528 3.59 85.3 µM 2.87E-4 Golgi 8 1.63E-4 0.31
18 SGTC_170 4197-0004 3.50 226.0 µM 3.99E-4 11 2.34E-4 0.20
19 SGTC_2367 9070478 3.46 135.4 µM 4.59E-4 cell wall 15 2.72E-4 0.08
20 SGTC_3165 9101544 3.43 49.5 µM 5.03E-4 9 3.00E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.17E-20 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.140 5.03E-16 YMR069W NAT4 hom N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
0.086 5.25E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.086 6.87E-7 YLR188W MDL1 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
0.083 1.52E-6 YDL057W_p YDL057W_p hom Putative protein of unknown function; YDL057W is not an essential gene
0.081 3.03E-6 YML096W_p YML096W_p hom Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
0.080 3.60E-6 YEL072W RMD6 hom Protein required for sporulation
0.078 6.17E-6 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.077 7.19E-6 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.076 9.92E-6 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.076 1.04E-5 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.072 2.91E-5 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.072 3.17E-5 YML063W RPS1B hom Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication
0.071 3.56E-5 YMR122C_d YMR122C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071 3.72E-5 YIR039C YPS6 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance