YDL090C / RAM1

Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL090C / RAM1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:5.82|P-value:4.51E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.29|P-value:4.85E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:5.41|P-value:1.84E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.56|P-value:2.55E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.49|P-value:3.18E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:7.19|P-value:2.08E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:4.99|P-value:7.14E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.50|P-value:5.94E-16 ID:SGTC_232|Compound:clozapine|FD-Score:7.84|P-value:1.08E-9 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.58|P-value:2.45E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:5.53|P-value:1.24E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:11.80|P-value:8.86E-20 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.22|P-value:5.86E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:7.02|P-value:4.30E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.44|P-value:3.17E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.51|P-value:2.57E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.22|P-value:3.45E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:8.26|P-value:1.42E-10 ID:SGTC_445|Compound:e6 berbamine|FD-Score:10.00|P-value:9.09E-15 ID:SGTC_447|Compound:ml7|FD-Score:5.05|P-value:5.95E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:8.48|P-value:4.88E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.68|P-value:1.59E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.78|P-value:1.37E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.31|P-value:5.11E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:13.10|P-value:8.12E-24 ID:SGTC_543|Compound:3844-1095|FD-Score:4.07|P-value:9.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.17|P-value:7.43E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.07|P-value:9.77E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.75|P-value:1.48E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:14.90|P-value:2.34E-30 ID:SGTC_651|Compound:3253-0966|FD-Score:5.16|P-value:4.23E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:-4.02|P-value:9.77E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:9.49|P-value:2.13E-13 ID:SGTC_691|Compound:1548-0686|FD-Score:4.59|P-value:2.38E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.34|P-value:4.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.59|P-value:2.34E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:11.60|P-value:3.85E-19 ID:SGTC_848|Compound:0368-0089|FD-Score:-4.04|P-value:9.38E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.18|P-value:7.29E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.38|P-value:4.23E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:12.00|P-value:1.95E-20 ID:SGTC_900|Compound:1112-0045|FD-Score:5.70|P-value:7.03E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.21|P-value:6.75E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:8.09|P-value:3.25E-10 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.25|P-value:5.39E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:29.20|P-value:7.08E-111 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.18|P-value:7.34E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.64|P-value:2.07E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.29|P-value:5.48E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.02|P-value:2.24E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.17|P-value:7.52E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.84|P-value:4.18E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:5.22|P-value:3.46E-5 ID:SGTC_1547|Compound:harmine|FD-Score:5.90|P-value:3.44E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:4.19|P-value:7.13E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.83|P-value:3.66E-6 ID:SGTC_1750|Compound:st081859|FD-Score:7.80|P-value:1.33E-9 ID:SGTC_1754|Compound:st042065|FD-Score:14.90|P-value:2.12E-30 ID:SGTC_1760|Compound:st045453|FD-Score:17.10|P-value:1.81E-39 ID:SGTC_1781|Compound:st038725|FD-Score:6.31|P-value:7.43E-7 ID:SGTC_1797|Compound:st048695|FD-Score:7.96|P-value:6.29E-10 ID:SGTC_1831|Compound:st055328|FD-Score:4.54|P-value:2.69E-4 ID:SGTC_1974|Compound:st069448|FD-Score:5.79|P-value:5.09E-6 ID:SGTC_1991|Compound:st073000|FD-Score:10.30|P-value:1.50E-15 ID:SGTC_2006|Compound:4011487|FD-Score:29.10|P-value:6.35E-110 ID:SGTC_2009|Compound:4012297|FD-Score:5.75|P-value:5.82E-6 ID:SGTC_2021|Compound:4019055|FD-Score:4.74|P-value:1.54E-4 ID:SGTC_2028|Compound:5153890|FD-Score:8.11|P-value:3.05E-10 ID:SGTC_2036|Compound:5160441|FD-Score:19.60|P-value:4.67E-51 ID:SGTC_2053|Compound:5265679|FD-Score:5.05|P-value:5.99E-5 ID:SGTC_2102|Compound:5377816|FD-Score:-4.32|P-value:4.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.00|P-value:2.35E-6 ID:SGTC_2257|Compound:7960413|FD-Score:5.49|P-value:1.43E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.02|P-value:2.23E-6 ID:SGTC_2451|Compound:5856223|FD-Score:4.99|P-value:7.17E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.75|P-value:1.31E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.55|P-value:9.93E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.27|P-value:8.83E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:8.31|P-value:1.13E-10 ID:SGTC_2736|Compound:butenafine|FD-Score:5.86|P-value:4.01E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.30|P-value:2.38E-18 ID:SGTC_2790|Compound:5423970|FD-Score:11.40|P-value:1.62E-18 ID:SGTC_2851|Compound:9015922|FD-Score:4.87|P-value:1.05E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.72|P-value:6.38E-6 ID:SGTC_2896|Compound:9052656|FD-Score:7.95|P-value:6.64E-10 ID:SGTC_3019|Compound:9081971|FD-Score:5.79|P-value:5.00E-6 ID:SGTC_3037|Compound:9091026|FD-Score:4.48|P-value:3.27E-4 ID:SGTC_3094|Compound:9117742|FD-Score:6.28|P-value:8.34E-7 ID:SGTC_3101|Compound:9120531|FD-Score:-5.02|P-value:5.67E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-4.62|P-value:1.87E-4 ID:SGTC_3120|Compound:9124077|FD-Score:21.60|P-value:2.01E-61 ID:SGTC_3148|Compound:9097893|FD-Score:8.23|P-value:1.69E-10 ID:SGTC_3152|Compound:9099253|FD-Score:11.40|P-value:1.17E-18 ID:SGTC_3266|Compound:9136860|FD-Score:-4.40|P-value:3.53E-4 ID:SGTC_3269|Compound:9137823|FD-Score:6.17|P-value:1.25E-6 ID:SGTC_3288|Compound:9119690|FD-Score:11.30|P-value:3.12E-18 ID:SGTC_3292|Compound:9120825|FD-Score:-4.03|P-value:9.56E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.10|P-value:3.02E-8 ID:SGTC_3337|Compound:9144342|FD-Score:7.38|P-value:8.90E-9 ID:SGTC_15|Compound:0266-0086|FD-Score:5.82|P-value:4.51E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.29|P-value:4.85E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:5.41|P-value:1.84E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.56|P-value:2.55E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.49|P-value:3.18E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:7.19|P-value:2.08E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:4.99|P-value:7.14E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.50|P-value:5.94E-16 ID:SGTC_232|Compound:clozapine|FD-Score:7.84|P-value:1.08E-9 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.58|P-value:2.45E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:5.53|P-value:1.24E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:11.80|P-value:8.86E-20 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.22|P-value:5.86E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:7.02|P-value:4.30E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.44|P-value:3.17E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.51|P-value:2.57E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.22|P-value:3.45E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:8.26|P-value:1.42E-10 ID:SGTC_445|Compound:e6 berbamine|FD-Score:10.00|P-value:9.09E-15 ID:SGTC_447|Compound:ml7|FD-Score:5.05|P-value:5.95E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:8.48|P-value:4.88E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.68|P-value:1.59E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.78|P-value:1.37E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.31|P-value:5.11E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:13.10|P-value:8.12E-24 ID:SGTC_543|Compound:3844-1095|FD-Score:4.07|P-value:9.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.17|P-value:7.43E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.07|P-value:9.77E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.75|P-value:1.48E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:14.90|P-value:2.34E-30 ID:SGTC_651|Compound:3253-0966|FD-Score:5.16|P-value:4.23E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:-4.02|P-value:9.77E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:9.49|P-value:2.13E-13 ID:SGTC_691|Compound:1548-0686|FD-Score:4.59|P-value:2.38E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.34|P-value:4.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.59|P-value:2.34E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:11.60|P-value:3.85E-19 ID:SGTC_848|Compound:0368-0089|FD-Score:-4.04|P-value:9.38E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.18|P-value:7.29E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.38|P-value:4.23E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:12.00|P-value:1.95E-20 ID:SGTC_900|Compound:1112-0045|FD-Score:5.70|P-value:7.03E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.21|P-value:6.75E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:8.09|P-value:3.25E-10 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.25|P-value:5.39E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:29.20|P-value:7.08E-111 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.18|P-value:7.34E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.64|P-value:2.07E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.29|P-value:5.48E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.02|P-value:2.24E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.17|P-value:7.52E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.84|P-value:4.18E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:5.22|P-value:3.46E-5 ID:SGTC_1547|Compound:harmine|FD-Score:5.90|P-value:3.44E-6 ID:SGTC_1581|Compound:himbacine|FD-Score:4.19|P-value:7.13E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.83|P-value:3.66E-6 ID:SGTC_1750|Compound:st081859|FD-Score:7.80|P-value:1.33E-9 ID:SGTC_1754|Compound:st042065|FD-Score:14.90|P-value:2.12E-30 ID:SGTC_1760|Compound:st045453|FD-Score:17.10|P-value:1.81E-39 ID:SGTC_1781|Compound:st038725|FD-Score:6.31|P-value:7.43E-7 ID:SGTC_1797|Compound:st048695|FD-Score:7.96|P-value:6.29E-10 ID:SGTC_1831|Compound:st055328|FD-Score:4.54|P-value:2.69E-4 ID:SGTC_1974|Compound:st069448|FD-Score:5.79|P-value:5.09E-6 ID:SGTC_1991|Compound:st073000|FD-Score:10.30|P-value:1.50E-15 ID:SGTC_2006|Compound:4011487|FD-Score:29.10|P-value:6.35E-110 ID:SGTC_2009|Compound:4012297|FD-Score:5.75|P-value:5.82E-6 ID:SGTC_2021|Compound:4019055|FD-Score:4.74|P-value:1.54E-4 ID:SGTC_2028|Compound:5153890|FD-Score:8.11|P-value:3.05E-10 ID:SGTC_2036|Compound:5160441|FD-Score:19.60|P-value:4.67E-51 ID:SGTC_2053|Compound:5265679|FD-Score:5.05|P-value:5.99E-5 ID:SGTC_2102|Compound:5377816|FD-Score:-4.32|P-value:4.39E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.00|P-value:2.35E-6 ID:SGTC_2257|Compound:7960413|FD-Score:5.49|P-value:1.43E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.02|P-value:2.23E-6 ID:SGTC_2451|Compound:5856223|FD-Score:4.99|P-value:7.17E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.75|P-value:1.31E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.55|P-value:9.93E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.27|P-value:8.83E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:8.31|P-value:1.13E-10 ID:SGTC_2736|Compound:butenafine|FD-Score:5.86|P-value:4.01E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.30|P-value:2.38E-18 ID:SGTC_2790|Compound:5423970|FD-Score:11.40|P-value:1.62E-18 ID:SGTC_2851|Compound:9015922|FD-Score:4.87|P-value:1.05E-4 ID:SGTC_2858|Compound:9025781|FD-Score:5.72|P-value:6.38E-6 ID:SGTC_2896|Compound:9052656|FD-Score:7.95|P-value:6.64E-10 ID:SGTC_3019|Compound:9081971|FD-Score:5.79|P-value:5.00E-6 ID:SGTC_3037|Compound:9091026|FD-Score:4.48|P-value:3.27E-4 ID:SGTC_3094|Compound:9117742|FD-Score:6.28|P-value:8.34E-7 ID:SGTC_3101|Compound:9120531|FD-Score:-5.02|P-value:5.67E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-4.62|P-value:1.87E-4 ID:SGTC_3120|Compound:9124077|FD-Score:21.60|P-value:2.01E-61 ID:SGTC_3148|Compound:9097893|FD-Score:8.23|P-value:1.69E-10 ID:SGTC_3152|Compound:9099253|FD-Score:11.40|P-value:1.17E-18 ID:SGTC_3266|Compound:9136860|FD-Score:-4.40|P-value:3.53E-4 ID:SGTC_3269|Compound:9137823|FD-Score:6.17|P-value:1.25E-6 ID:SGTC_3288|Compound:9119690|FD-Score:11.30|P-value:3.12E-18 ID:SGTC_3292|Compound:9120825|FD-Score:-4.03|P-value:9.56E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.10|P-value:3.02E-8 ID:SGTC_3337|Compound:9144342|FD-Score:7.38|P-value:8.90E-9

Top fitness defect scores for YDL090C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1130 3454-2858 29.20 15.9 µM 7.08E-111 NEO1 3 6.96E-188
2 SGTC_2006 4011487 29.10 200.0 µM 6.35E-110 endomembrane recycling 2 2.95E-186
3 SGTC_3120 9124077 21.60 49.5 µM 2.01E-61 1 1.68E-103
4 SGTC_2036 5160441 19.60 105.0 µM 4.67E-51 NEO1 3 8.04E-86
5 SGTC_1760 st045453 17.10 10.4 µM 1.81E-39 NEO1-PIK1 10 4.61E-66
6 SGTC_1754 st042065 14.90 16.1 µM 2.12E-30 NEO1-PIK1 10 1.33E-50
7 SGTC_649 1123-0311 14.90 367.0 µM 2.34E-30 endomembrane recycling 4 1.57E-50
8 SGTC_535 2293-4129 13.10 48.2 µM 8.12E-24 NEO1 5 2.17E-39
9 SGTC_888 0916-0002 12.00 7.0 µM 1.95E-20 NEO1 4 1.24E-33
10 SGTC_301 4119-0100 11.80 24.5 µM 8.86E-20 NEO1 12 1.62E-32
11 SGTC_788 1182-0090 11.60 188.0 µM 3.85E-19 endomembrane recycling 9 1.98E-31
12 SGTC_3152 9099253 11.40 49.5 µM 1.17E-18 NEO1-PIK1 16 1.30E-30
13 SGTC_2790 5423970 11.40 71.4 µM 1.62E-18 endomembrane recycling 7 2.29E-30
14 SGTC_2776 terbinafine 11.30 19.9 µM 2.38E-18 cell wall signaling 9 4.37E-30
15 SGTC_3288 9119690 11.30 36.2 µM 3.12E-18 2 6.95E-30
16 SGTC_221 trifluoperazine 10.50 10.3 µM 5.94E-16 NEO1-PIK1 55 5.23E-26
17 SGTC_1991 st073000 10.30 8.9 µM 1.50E-15 NEO1 9 2.51E-25
18 SGTC_445 e6 berbamine 10.00 66.0 µM 9.09E-15 NEO1-PIK1 5 5.40E-24
19 SGTC_658 3253-0951 9.49 102.0 µM 2.13E-13 calcium & mitochondrial duress 4 1.15E-21
20 SGTC_449 xestospongin c 8.48 11.2 µM 4.88E-11 NEO1-PIK1 4 1.16E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.528 1.45E-238 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.518 1.18E-227 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.491 5.07E-202 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.470 3.04E-183 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.466 2.50E-179 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.463 4.14E-176 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.450 4.26E-166 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.444 2.46E-161 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.442 8.46E-160 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.440 3.77E-158 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.420 3.29E-142 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.414 3.91E-138 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.409 2.10E-134 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.404 8.90E-131 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.381 1.92E-115 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W