HIPHOP chemogenomics database

YDL096C_d / OPI6

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL096C / OPI6

Click on Significant Values for Screen Details

Top fitness defect scores for YDL096C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_143	4032-1194	16.30	15.7 µM	2.54E-69		2	3.56E-60
2	SGTC_2413	inermin	12.50	26.1 µM	7.99E-42		3	2.05E-36
3	SGTC_800	3448-7362	8.95	155.0 µM	3.05E-22	translation	12	1.75E-19
4	SGTC_2289	7946404	8.34	165.1 µM	1.56E-19		14	3.85E-17
5	SGTC_708	3448-5400	7.17	146.0 µM	6.53E-15		6	3.87E-13
6	SGTC_453	enantio-paf c16	6.86	10.0 µM	7.83E-14		27	3.33E-12
7	SGTC_531	3788-1495	6.27	174.0 µM	7.84E-12	unfolded protein response	8	1.80E-10
8	SGTC_2602	kawain	5.13	100.0 µM	1.74E-8		8	1.44E-7
9	SGTC_117	lucigenin	5.04	22.1 µM	3.04E-8	redox potentiating	59	2.34E-7
10	SGTC_663	1486-0733	4.83	13.9 µM	1.04E-7	cell wall signaling	34	6.78E-7
11	SGTC_353	1988-1175	4.61	58.3 µM	3.53E-7	unfolded protein response	15	1.97E-6
12	SGTC_2399	5884133	4.21	200.0 µM	3.05E-6	cell wall signaling	62	1.28E-5
13	SGTC_786	4544-0069	3.99	423.0 µM	9.14E-6		24	3.33E-5
14	SGTC_2724	maprotiline	3.98	69.6 µM	9.32E-6	ERG2	15	3.39E-5
15	SGTC_758	0868-0029	3.86	16.0 µM	1.67E-5		6	5.63E-5
16	SGTC_1687	st020778	3.85	55.4 µM	1.80E-5		181	6.01E-5
17	SGTC_2119	5528445	3.58	120.6 µM	6.00E-5		34	1.71E-4
18	SGTC_2007	4011539	3.58	71.8 µM	6.09E-5	cell wall signaling	81	1.74E-4
19	SGTC_410	α-linolenic acid	3.50	100.0 µM	8.35E-5	excess fatty acid	50	2.29E-4
20	SGTC_22	0964-0034	3.49	14.5 µM	8.73E-5	unfolded protein response	62	2.38E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.395	4.03E-125	YDL095W	PMT1	hom	Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.345	2.11E-94	YOR085W	OST3	hom	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.297	5.93E-69	YAL058W	CNE1	hom	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.290	7.43E-66	YOR002W	ALG6	hom	Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.284	1.92E-63	YNL322C	KRE1	hom	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.283	7.89E-63	YMR200W	ROT1	het	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.273	3.43E-58	YFL038C	YPT1	het	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.265	6.53E-55	YBL082C	ALG3	hom	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.251	3.85E-49	YAL056C-A_d	YAL056C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.232	4.27E-42	YKL096C-B_p	YKL096C-B_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.207	6.68E-34	YJL139C	YUR1	hom	Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication
0.206	1.35E-33	YDR304C	CPR5	hom	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.206	2.27E-33	YOR246C	ENV9	hom	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.199	3.97E-31	YNL219C	ALG9	hom	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.190	1.71E-28	YGR166W	TRS65	hom	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response