HIPHOP chemogenomics database

YDL102W / POL3

Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDL102W / POL3

Click on Significant Values for Screen Details

Top fitness defect scores for YDL102W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_264	promethazine	6.62	12.5 mM	2.69E-11	DNA intercalators	9	1.76E-11	0.95
2	SGTC_1468	k284-1086	6.12	134.0 µM	6.86E-10	DNA intercalators	4	4.76E-10	0.42
3	SGTC_145	3737-0113	6.10	38.4 µM	7.50E-10	DNA intercalators	17	5.20E-10	0.06
4	SGTC_3126	9127922	5.88	49.5 µM	2.96E-9	fatty acid desaturase (OLE1)	10	2.11E-9	0.08
5	SGTC_1515	3460-0031	5.85	42.1 µM	3.55E-9	DNA intercalators	4	2.53E-9	1.57
6	SGTC_844	0330-0132	5.29	15.3 µM	7.99E-8		2	6.02E-8	0.43
7	SGTC_126	0417-1624	5.23	672.5 µM	1.11E-7	DNA intercalators	7	8.45E-8	0.06
8	SGTC_144	4161-2749	5.12	112.4 µM	1.97E-7	DNA intercalators	6	1.51E-7	0.28
9	SGTC_2388	9080168	4.79	200.0 µM	1.03E-6		1	8.14E-7	0.76
10	SGTC_119	0121-0043	4.67	24.8 µM	1.88E-6	mitochondrial stress	12	1.50E-6	0.18
11	SGTC_112	phenothiazine	4.55	287.2 µM	3.26E-6	unfolded protein response	3	2.63E-6	0.26
12	SGTC_450	aminopyrene	4.28	156.0 nM	1.11E-5		5	9.15E-6	0.09
13	SGTC_175	3793-3120	4.25	23.7 µM	1.30E-5		2	1.07E-5	0.20
14	SGTC_3167	9103034	4.00	49.5 µM	3.71E-5	RPP1 & pyrimidine depletion	4	3.12E-5	0.11
15	SGTC_364	0083-0097	3.98	67.7 µM	4.07E-5		9	3.43E-5	0.32
16	SGTC_2883	9059145	3.96	45.5 µM	4.36E-5		5	3.68E-5	0.20
17	SGTC_3326	9140064	3.93	16.4 µM	5.04E-5		6	4.27E-5	0.36
18	SGTC_2362	9071156	3.91	126.0 µM	5.44E-5		4	4.61E-5	0.28
19	SGTC_917	harmaline	3.87	728.1 nM	6.42E-5	ergosterol biosynthesis	10	5.46E-5	0.29
20	SGTC_3210	9128157	3.82	49.5 µM	7.83E-5		15	6.67E-5	0.22

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.279	3.52E-61	YMR168C	CEP3	het	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.274	8.49E-59	YGL118C_d	YGL118C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.262	6.78E-54	YHL039W	EFM1	hom	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.246	2.61E-47	YMR166C_p	YMR166C_p	hom	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.239	6.06E-45	YJL025W	RRN7	het	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.237	5.99E-44	YMR289W	ABZ2	hom	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.232	2.45E-42	YEL032W	MCM3	het	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.232	2.97E-42	YGR065C	VHT1	het	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.230	1.82E-41	YMR262W_p	YMR262W_p	hom	Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.211	5.25E-35	YOR133W	EFT1	hom	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.198	6.96E-31	YDR401W_d	YDR401W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.176	1.41E-24	YDL223C	HBT1	hom	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.171	1.90E-23	YDR054C	CDC34	het	Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.167	2.28E-22	YNL264C	PDR17	hom	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.160	1.36E-20	YHR037W	PUT2	hom	Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism