YDL107W / MSS2

Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL107W / MSS2

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.61|P-value:8.97E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.74|P-value:7.02E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:4.66|P-value:9.95E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:17.90|P-value:1.48E-75 ID:SGTC_168|Compound:3970-0862|FD-Score:6.19|P-value:1.20E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.13|P-value:7.19E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.82|P-value:5.03E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:6.55|P-value:1.09E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:14.30|P-value:5.55E-49 ID:SGTC_386|Compound:1509-0011|FD-Score:6.56|P-value:1.02E-11 ID:SGTC_734|Compound:2023-0417|FD-Score:3.14|P-value:7.05E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.11|P-value:7.92E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.34|P-value:4.83E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:5.62|P-value:4.69E-9 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.56|P-value:1.11E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.50|P-value:1.58E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.86|P-value:4.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:13.00|P-value:7.33E-41 ID:SGTC_1724|Compound:st037281|FD-Score:3.15|P-value:6.78E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.32|P-value:5.31E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.30|P-value:3.90E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.22|P-value:4.17E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.10|P-value:6.36E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.67|P-value:9.37E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.05|P-value:1.37E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.01|P-value:2.22E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.73|P-value:7.25E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-2.98|P-value:9.71E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.23|P-value:5.04E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.11|P-value:7.94E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.37|P-value:2.98E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.14|P-value:5.67E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.24|P-value:4.81E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.21|P-value:5.38E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.61|P-value:8.97E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.74|P-value:7.02E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:4.66|P-value:9.95E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:17.90|P-value:1.48E-75 ID:SGTC_168|Compound:3970-0862|FD-Score:6.19|P-value:1.20E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.13|P-value:7.19E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.82|P-value:5.03E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:6.55|P-value:1.09E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:14.30|P-value:5.55E-49 ID:SGTC_386|Compound:1509-0011|FD-Score:6.56|P-value:1.02E-11 ID:SGTC_734|Compound:2023-0417|FD-Score:3.14|P-value:7.05E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.11|P-value:7.92E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.34|P-value:4.83E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:5.62|P-value:4.69E-9 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.56|P-value:1.11E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.50|P-value:1.58E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.86|P-value:4.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:13.00|P-value:7.33E-41 ID:SGTC_1724|Compound:st037281|FD-Score:3.15|P-value:6.78E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.32|P-value:5.31E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.30|P-value:3.90E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.22|P-value:4.17E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.20|P-value:4.48E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.10|P-value:6.36E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.67|P-value:9.37E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.05|P-value:1.37E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.01|P-value:2.22E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.73|P-value:7.25E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-2.98|P-value:9.71E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.23|P-value:5.04E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.11|P-value:7.94E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.37|P-value:2.98E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.14|P-value:5.67E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.24|P-value:4.81E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.21|P-value:5.38E-4

Top fitness defect scores for YDL107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 17.90 6.9 µM 1.48E-75 11 6.40E-72
2 SGTC_236 1509-0011 14.30 5.3 µM 5.55E-49 111 1.07E-46
3 SGTC_1635 st007035 13.00 42.4 µM 7.33E-41 51 5.48E-39
4 SGTC_386 1509-0011 6.56 3.1 µM 1.02E-11 84 2.77E-11
5 SGTC_233 rapamycin 6.55 362.0 pM 1.09E-11 1 2.96E-11
6 SGTC_168 3970-0862 6.19 530.5 µM 1.20E-10 38 2.92E-10
7 SGTC_1123 mangostin 5.62 811.3 nM 4.69E-9 mitochondrial response to ROS 13 9.58E-9
8 SGTC_87 0100-0052 4.66 35.5 µM 9.95E-7 66 1.59E-6
9 SGTC_991 3996-0057 4.34 64.7 µM 4.83E-6 14 7.20E-6
10 SGTC_1902 st060212 4.32 70.5 µM 5.31E-6 6 7.88E-6
11 SGTC_46 0329-0187a 4.17 2.2 µM 1.07E-5 64 1.53E-5
12 SGTC_2767 sibutramine 4.01 71.5 µM 2.22E-5 20 3.09E-5
13 SGTC_1376 2910-0861 3.86 41.3 µM 4.18E-5 20 5.67E-5
14 SGTC_220 paclitaxel 3.82 373.4 µM 5.03E-5 10 6.76E-5
15 SGTC_59 0330-0160 3.74 1.3 µM 7.02E-5 126 9.30E-5
16 SGTC_2832 7992762 3.73 52.0 µM 7.25E-5 38 9.60E-5
17 SGTC_2556 citropten 3.67 84.6 µM 9.37E-5 31 1.23E-4
18 SGTC_1828 st055811 3.44 49.0 µM 2.27E-4 17 2.86E-4
19 SGTC_3006 9075424 3.44 71.4 µM 2.27E-4 22 2.87E-4
20 SGTC_3008 9078912 3.37 71.4 µM 2.98E-4 36 3.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.674 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.663 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.657 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.617 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.614 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.613 0 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.612 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.602 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.597 1.98E-323 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.597 1.98E-323 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.593 1.40E-317 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.584 7.83E-306 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.579 1.30E-298 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.568 4.58E-286 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.560 1.25E-275 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex