YDL109C_p

Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL109C / YDL109C

Click on Significant Values for Screen Details ID:SGTC_110|Compound:0850-0284|FD-Score:-3.87|P-value:3.46E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.03|P-value:1.77E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.01|P-value:9.61E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.15|P-value:5.78E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-3.87|P-value:3.47E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.00|P-value:9.85E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.17|P-value:5.39E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.06|P-value:8.08E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.87|P-value:3.46E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.03|P-value:1.77E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.01|P-value:9.61E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.15|P-value:5.78E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-3.87|P-value:3.47E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.00|P-value:9.85E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.17|P-value:5.39E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.06|P-value:8.08E-4

Top fitness defect scores for YDL109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1937 st074714 2.83 47.2 µM 0.00258 97 0.00234
2 SGTC_2837 9008476 2.81 45.5 µM 0.00276 102 0.00251
3 SGTC_2926 9010726 2.80 65.2 µM 0.00281 92 0.00255
4 SGTC_1771 st048882 2.79 4.2 µM 0.00292 RPP1 & pyrimidine depletion 80 0.00265
5 SGTC_2503 beta-caryophyllene alcohol 2.77 24.7 µM 0.00308 48 0.00279
6 SGTC_1774 st048371 2.73 48.5 µM 0.00346 RNA processing & uracil transport 92 0.00314
7 SGTC_3106 9121286 2.71 49.5 µM 0.00373 73 0.00338
8 SGTC_1433 4060-0023 2.71 7.6 µM 0.00375 tubulin folding & SWR complex 74 0.00341
9 SGTC_2665 lovastatin 2.70 100.0 µM 0.00383 81 0.00347
10 SGTC_2268 7933382 2.65 153.8 µM 0.00438 125 0.00397
11 SGTC_1504 k297-0033 2.65 30.0 µM 0.00442 70 0.00401
12 SGTC_1574 spiramycin 2.63 23.7 µM 0.00470 108 0.00427
13 SGTC_1663 st014140 2.63 55.4 µM 0.00476 60S ribosome export 104 0.00432
14 SGTC_2379 9035213 2.62 200.0 µM 0.00482 106 0.00437
15 SGTC_943 3253-1379 2.62 105.0 µM 0.00485 104 0.00440
16 SGTC_1762 st045503 2.60 25.5 µM 0.00510 112 0.00463
17 SGTC_864 0469-0573 2.59 172.0 µM 0.00534 103 0.00484
18 SGTC_2325 6158266 2.59 200.0 µM 0.00534 104 0.00485
19 SGTC_2193 5925765 2.58 200.0 µM 0.00537 58 0.00487
20 SGTC_2172 5754775 2.58 163.9 µM 0.00539 106 0.00489

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.46E-15 YER135C_d YER135C_d hom Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
0.111 1.11E-10 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.101 4.47E-9 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.095 3.65E-8 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.094 4.21E-8 YGR277C CAB4 het Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
0.086 5.91E-7 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.082 2.07E-6 YMR303C ADH2 hom Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
0.080 3.44E-6 YDR350C ATP22 hom Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane
0.079 5.25E-6 YNL133C FYV6 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
0.074 1.87E-5 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.073 2.35E-5 YDR052C DBF4 het Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
0.071 3.61E-5 YOR315W SFG1 hom Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
0.069 6.27E-5 YLR240W VPS34 hom Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.068 7.94E-5 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.067 9.33E-5 YGL038C OCH1 hom Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins