YDL110C / TMA17

Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL110C / TMA17

Click on Significant Values for Screen Details ID:SGTC_156|Compound:3474-0145|FD-Score:2.92|P-value:5.94E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.12|P-value:2.55E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.88|P-value:5.36E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.22|P-value:9.33E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:3.08|P-value:3.04E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:2.80|P-value:9.36E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.53|P-value:3.19E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:4.11|P-value:2.25E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:3.45|P-value:6.24E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:2.82|P-value:8.73E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.03|P-value:2.97E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.77|P-value:9.75E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.27|P-value:7.54E-13 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.81|P-value:7.06E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.21|P-value:1.77E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.96|P-value:4.90E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.02|P-value:3.16E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-2.78|P-value:7.96E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.17|P-value:1.62E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.88|P-value:6.87E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.73|P-value:1.23E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.91|P-value:6.04E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.95|P-value:1.16E-8 ID:SGTC_1725|Compound:st036284|FD-Score:2.99|P-value:4.43E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.00|P-value:1.22E-8 ID:SGTC_2046|Compound:4110841|FD-Score:2.99|P-value:4.39E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.48|P-value:5.43E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-3.08|P-value:2.38E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-4.32|P-value:5.34E-7 ID:SGTC_2146|Compound:5545642|FD-Score:-3.52|P-value:3.41E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.37|P-value:8.68E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-2.73|P-value:9.68E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.08|P-value:3.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.91|P-value:4.81E-6 ID:SGTC_2585|Compound:alliin|FD-Score:3.11|P-value:2.70E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.37|P-value:6.92E-5 ID:SGTC_2925|Compound:9010536|FD-Score:2.97|P-value:4.89E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.92|P-value:5.94E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.12|P-value:2.55E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.88|P-value:5.36E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.22|P-value:9.33E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:3.08|P-value:3.04E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:2.80|P-value:9.36E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:-3.53|P-value:3.19E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:4.11|P-value:2.25E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:3.45|P-value:6.24E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:2.82|P-value:8.73E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.03|P-value:2.97E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.77|P-value:9.75E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.27|P-value:7.54E-13 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.81|P-value:7.06E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.21|P-value:1.77E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.96|P-value:4.90E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.02|P-value:3.16E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-2.78|P-value:7.96E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.17|P-value:1.62E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.88|P-value:6.87E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.73|P-value:1.23E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.91|P-value:6.04E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.95|P-value:1.16E-8 ID:SGTC_1725|Compound:st036284|FD-Score:2.99|P-value:4.43E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.00|P-value:1.22E-8 ID:SGTC_2046|Compound:4110841|FD-Score:2.99|P-value:4.39E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.48|P-value:5.43E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-3.08|P-value:2.38E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-4.32|P-value:5.34E-7 ID:SGTC_2146|Compound:5545642|FD-Score:-3.52|P-value:3.41E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.37|P-value:8.68E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-2.73|P-value:9.68E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.08|P-value:3.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.91|P-value:4.81E-6 ID:SGTC_2585|Compound:alliin|FD-Score:3.11|P-value:2.70E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.37|P-value:6.92E-5 ID:SGTC_2925|Compound:9010536|FD-Score:2.97|P-value:4.89E-4

Top fitness defect scores for YDL110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1741 st038134 5.00 10.2 µM 1.22E-8 10 2.92E-7
2 SGTC_842 0271-0008 4.11 11.1 µM 2.25E-6 heme biosynthesis & mitochondrial translocase 16 1.94E-5
3 SGTC_2103 5378138 3.48 10.0 µM 5.43E-5 31 2.54E-4
4 SGTC_845 0330-0138 3.45 4.5 µM 6.24E-5 32 2.85E-4
5 SGTC_2162 5663267 3.37 200.0 µM 8.68E-5 26 3.72E-4
6 SGTC_1211 1056-0033 3.21 32.3 µM 1.77E-4 25 6.62E-4
7 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.12 8.0 µM 2.55E-4 62 8.93E-4
8 SGTC_2585 alliin 3.11 100.0 µM 2.70E-4 71 9.34E-4
9 SGTC_778 3456-2434 3.08 196.0 µM 3.04E-4 mitochondrial response to ROS 129 0.00103
10 SGTC_2514 salinomycin 3.08 42.7 µM 3.12E-4 99 0.00105
11 SGTC_2046 4110841 2.99 106.0 µM 4.39E-4 iron homeostasis 62 0.00139
12 SGTC_1725 st036284 2.99 20.6 µM 4.43E-4 73 0.00140
13 SGTC_2925 9010536 2.97 32.5 µM 4.89E-4 azole & statin 98 0.00151
14 SGTC_1212 0520-0165 2.96 585.0 µM 4.90E-4 89 0.00152
15 SGTC_156 3474-0145 2.92 5.6 µM 5.94E-4 endomembrane recycling 108 0.00177
16 SGTC_1679 4130-1276 2.91 6.7 µM 6.04E-4 Golgi 129 0.00180
17 SGTC_1312 1218-2183 2.88 165.0 µM 6.87E-4 41 0.00200
18 SGTC_894 0960-0238 2.82 55.9 µM 8.73E-4 50 0.00242
19 SGTC_781 4335-2806 2.80 94.4 µM 9.36E-4 74 0.00257
20 SGTC_1114 scopoletin 2.78 1.7 µM 0.00101 63 0.00274

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 1.50E-76 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.285 1.13E-63 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.263 5.16E-54 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.243 4.61E-46 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.240 5.03E-45 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.234 1.03E-42 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.230 1.91E-41 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.229 3.03E-41 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.224 3.44E-39 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.222 9.37E-39 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.218 1.82E-37 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.217 5.14E-37 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.217 6.71E-37 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.215 2.49E-36 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.214 6.07E-36 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases