YDL115C / IWR1

RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL115C / IWR1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.89|P-value:7.28E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.34|P-value:5.48E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.52|P-value:4.96E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.40|P-value:4.45E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.26|P-value:7.33E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.71|P-value:2.09E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:4.47|P-value:6.40E-6 ID:SGTC_389|Compound:tpck|FD-Score:4.92|P-value:7.87E-7 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.16|P-value:2.37E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.51|P-value:5.20E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.80|P-value:1.03E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.60|P-value:2.15E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.32|P-value:6.00E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:5.17|P-value:2.18E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:3.21|P-value:8.46E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.60|P-value:3.58E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:3.95|P-value:5.70E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:3.63|P-value:1.93E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.70|P-value:2.18E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:7.54|P-value:8.88E-14 ID:SGTC_991|Compound:3996-0057|FD-Score:3.45|P-value:3.71E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.87|P-value:7.88E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.37|P-value:5.03E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:9.90|P-value:2.07E-22 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.50|P-value:3.15E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.50|P-value:3.15E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.79|P-value:1.44E-6 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.43|P-value:7.49E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.66|P-value:1.76E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.49|P-value:3.26E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.96|P-value:5.47E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.20|P-value:2.07E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.93|P-value:6.11E-5 ID:SGTC_1781|Compound:st038725|FD-Score:4.91|P-value:8.17E-7 ID:SGTC_1797|Compound:st048695|FD-Score:6.07|P-value:1.56E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.59|P-value:2.35E-8 ID:SGTC_1868|Compound:st057644|FD-Score:4.08|P-value:3.38E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.52|P-value:2.90E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.74|P-value:2.24E-11 ID:SGTC_2083|Compound:5306046|FD-Score:5.01|P-value:4.99E-7 ID:SGTC_2157|Compound:5649910|FD-Score:4.24|P-value:1.71E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.60|P-value:3.50E-6 ID:SGTC_2191|Compound:5911152|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_2441|Compound:5730946|FD-Score:6.73|P-value:2.42E-11 ID:SGTC_2515|Compound:chrysin|FD-Score:4.35|P-value:1.09E-5 ID:SGTC_2525|Compound:harmine|FD-Score:4.74|P-value:1.86E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.58|P-value:3.85E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.17|P-value:9.65E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.55|P-value:2.59E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.66|P-value:2.62E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.13|P-value:2.78E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.75|P-value:1.74E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.18|P-value:2.23E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.50|P-value:5.47E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.26|P-value:7.24E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.19|P-value:2.15E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.03|P-value:4.19E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.32|P-value:5.96E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.29|P-value:6.46E-4 ID:SGTC_3173|Compound:9105693|FD-Score:5.73|P-value:1.11E-8 ID:SGTC_3305|Compound:9127027|FD-Score:4.08|P-value:3.37E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.89|P-value:7.28E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.34|P-value:5.48E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.52|P-value:4.96E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.40|P-value:4.45E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.26|P-value:7.33E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.71|P-value:2.09E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:4.47|P-value:6.40E-6 ID:SGTC_389|Compound:tpck|FD-Score:4.92|P-value:7.87E-7 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.16|P-value:2.37E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.51|P-value:5.20E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:3.80|P-value:1.03E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.60|P-value:2.15E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.32|P-value:6.00E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:5.17|P-value:2.18E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:3.21|P-value:8.46E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.60|P-value:3.58E-6 ID:SGTC_856|Compound:0433-0016|FD-Score:3.95|P-value:5.70E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:3.63|P-value:1.93E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.70|P-value:2.18E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:7.54|P-value:8.88E-14 ID:SGTC_991|Compound:3996-0057|FD-Score:3.45|P-value:3.71E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.87|P-value:7.88E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.37|P-value:5.03E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:9.90|P-value:2.07E-22 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.50|P-value:3.15E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.50|P-value:3.15E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:4.79|P-value:1.44E-6 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.43|P-value:7.49E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.66|P-value:1.76E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.49|P-value:3.26E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.96|P-value:5.47E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.20|P-value:2.07E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.93|P-value:6.11E-5 ID:SGTC_1781|Compound:st038725|FD-Score:4.91|P-value:8.17E-7 ID:SGTC_1797|Compound:st048695|FD-Score:6.07|P-value:1.56E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.59|P-value:2.35E-8 ID:SGTC_1868|Compound:st057644|FD-Score:4.08|P-value:3.38E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.52|P-value:2.90E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.74|P-value:2.24E-11 ID:SGTC_2083|Compound:5306046|FD-Score:5.01|P-value:4.99E-7 ID:SGTC_2157|Compound:5649910|FD-Score:4.24|P-value:1.71E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.60|P-value:3.50E-6 ID:SGTC_2191|Compound:5911152|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_2441|Compound:5730946|FD-Score:6.73|P-value:2.42E-11 ID:SGTC_2515|Compound:chrysin|FD-Score:4.35|P-value:1.09E-5 ID:SGTC_2525|Compound:harmine|FD-Score:4.74|P-value:1.86E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.58|P-value:3.85E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.17|P-value:9.65E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.55|P-value:2.59E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.66|P-value:2.62E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.13|P-value:2.78E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.75|P-value:1.74E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.18|P-value:2.23E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.50|P-value:5.47E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.26|P-value:7.24E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.19|P-value:2.15E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:4.03|P-value:4.19E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.32|P-value:5.96E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.29|P-value:6.46E-4 ID:SGTC_3173|Compound:9105693|FD-Score:5.73|P-value:1.11E-8 ID:SGTC_3305|Compound:9127027|FD-Score:4.08|P-value:3.37E-5

Top fitness defect scores for YDL115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1073 triclabendazole 9.90 3.1 µM 2.07E-22 2 2.13E-23
2 SGTC_940 3232-1287 7.54 54.8 µM 8.88E-14 NEO1 7 2.35E-14
3 SGTC_1991 st073000 6.74 8.9 µM 2.24E-11 NEO1 24 7.69E-12
4 SGTC_2441 5730946 6.73 39.1 µM 2.42E-11 2 8.35E-12
5 SGTC_1797 st048695 6.07 56.8 µM 1.56E-9 NEO1 40 6.56E-10
6 SGTC_3173 9105693 5.73 49.5 µM 1.11E-8 4 5.10E-9
7 SGTC_1844 rapamycin 5.59 4.0 nM 2.35E-8 98 1.12E-8
8 SGTC_654 1124-0271 5.17 80.9 µM 2.18E-7 5 1.15E-7
9 SGTC_2083 5306046 5.01 65.9 µM 4.99E-7 7 2.74E-7
10 SGTC_389 tpck 4.92 16.7 µM 7.87E-7 18 4.42E-7
11 SGTC_1781 st038725 4.91 66.3 µM 8.17E-7 NEO1 75 4.59E-7
12 SGTC_1298 1079-1278 4.79 263.0 µM 1.44E-6 DNA damage response 8 8.32E-7
13 SGTC_2626 ethyl orsellinate 4.75 100.0 µM 1.74E-6 17 1.01E-6
14 SGTC_2525 harmine 4.74 47.9 µM 1.86E-6 ergosterol biosynthesis 7 1.08E-6
15 SGTC_301 4119-0100 4.71 24.5 µM 2.09E-6 NEO1 60 1.23E-6
16 SGTC_888 0916-0002 4.70 7.0 µM 2.18E-6 NEO1 31 1.28E-6
17 SGTC_2187 6125751 4.60 200.0 µM 3.50E-6 RSC complex & mRNA processing 7 2.10E-6
18 SGTC_800 3448-7362 4.60 155.0 µM 3.58E-6 translation 111 2.16E-6
19 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.58 66.7 µM 3.85E-6 6 2.33E-6
20 SGTC_18 0111-0177 4.52 500.0 nM 4.96E-6 43 3.03E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.282 1.76E-62 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.240 4.18E-45 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.234 9.26E-43 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.210 9.00E-35 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.194 8.25E-30 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.194 8.03E-30 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.194 1.06E-29 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.192 3.04E-29 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.191 5.37E-29 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.184 5.87E-27 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.181 4.75E-26 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.177 5.11E-25 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.171 1.73E-23 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.167 2.27E-22 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.166 4.36E-22 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP