YDL122W / UBP1

Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL122W / UBP1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.75|P-value:6.34E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.68|P-value:1.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:13.60|P-value:1.83E-43 ID:SGTC_114|Compound:0364-0001|FD-Score:6.48|P-value:2.08E-11 ID:SGTC_143|Compound:4032-1194|FD-Score:4.41|P-value:3.51E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:7.95|P-value:3.02E-16 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.14|P-value:6.65E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.40|P-value:3.06E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.14|P-value:6.63E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.37|P-value:4.99E-6 ID:SGTC_417|Compound:st075190|FD-Score:-3.59|P-value:1.45E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-5.20|P-value:7.30E-8 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.33|P-value:3.94E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.82|P-value:4.59E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:3.28|P-value:4.03E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.30|P-value:3.83E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-7.25|P-value:1.07E-13 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.11|P-value:1.64E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.15|P-value:6.50E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-3.96|P-value:3.17E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:-5.00|P-value:2.16E-7 ID:SGTC_971|Compound:1315-0384|FD-Score:4.95|P-value:2.31E-7 ID:SGTC_983|Compound:1491-0821|FD-Score:4.54|P-value:1.90E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.97|P-value:2.04E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.84|P-value:5.25E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.79|P-value:5.44E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.19|P-value:5.72E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.12|P-value:8.29E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.88|P-value:3.74E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.22|P-value:5.00E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.43|P-value:2.33E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.15|P-value:6.48E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.89|P-value:3.20E-7 ID:SGTC_1750|Compound:st081859|FD-Score:3.52|P-value:1.67E-4 ID:SGTC_1772|Compound:st048439|FD-Score:7.15|P-value:1.67E-13 ID:SGTC_1806|Compound:st050005|FD-Score:3.30|P-value:3.79E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.37|P-value:3.31E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.16|P-value:1.31E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.24|P-value:4.65E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.04|P-value:9.38E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.07|P-value:8.68E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.99|P-value:2.40E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.09|P-value:8.08E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.15|P-value:6.44E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.76|P-value:6.15E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.05|P-value:9.07E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.82|P-value:5.66E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-4.24|P-value:9.05E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.83|P-value:5.40E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.16|P-value:6.33E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.10|P-value:7.64E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-4.72|P-value:9.35E-7 ID:SGTC_2931|Compound:9014674|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.77|P-value:6.06E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.18|P-value:6.63E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.39|P-value:3.11E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.14|P-value:6.64E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.48|P-value:1.94E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.64|P-value:1.03E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.75|P-value:6.34E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.68|P-value:1.04E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:13.60|P-value:1.83E-43 ID:SGTC_114|Compound:0364-0001|FD-Score:6.48|P-value:2.08E-11 ID:SGTC_143|Compound:4032-1194|FD-Score:4.41|P-value:3.51E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:7.95|P-value:3.02E-16 ID:SGTC_225|Compound:nsc-122657|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.14|P-value:6.65E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.40|P-value:3.06E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.14|P-value:6.63E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.37|P-value:4.99E-6 ID:SGTC_417|Compound:st075190|FD-Score:-3.59|P-value:1.45E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-5.20|P-value:7.30E-8 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.33|P-value:3.94E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.82|P-value:4.59E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:3.28|P-value:4.03E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.30|P-value:3.83E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-7.25|P-value:1.07E-13 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.11|P-value:1.64E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.15|P-value:6.50E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-3.96|P-value:3.17E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:-5.00|P-value:2.16E-7 ID:SGTC_971|Compound:1315-0384|FD-Score:4.95|P-value:2.31E-7 ID:SGTC_983|Compound:1491-0821|FD-Score:4.54|P-value:1.90E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.97|P-value:2.04E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.84|P-value:5.25E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.79|P-value:5.44E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.19|P-value:5.72E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.12|P-value:8.29E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.88|P-value:3.74E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.22|P-value:5.00E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.43|P-value:2.33E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.15|P-value:6.48E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.89|P-value:3.20E-7 ID:SGTC_1750|Compound:st081859|FD-Score:3.52|P-value:1.67E-4 ID:SGTC_1772|Compound:st048439|FD-Score:7.15|P-value:1.67E-13 ID:SGTC_1806|Compound:st050005|FD-Score:3.30|P-value:3.79E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.37|P-value:3.31E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.16|P-value:1.31E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.24|P-value:4.65E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.04|P-value:9.38E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.07|P-value:8.68E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.99|P-value:2.40E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.09|P-value:8.08E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.15|P-value:6.44E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.76|P-value:6.15E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.05|P-value:9.07E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.82|P-value:5.66E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-4.24|P-value:9.05E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.83|P-value:5.40E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.16|P-value:6.33E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.10|P-value:7.64E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-4.72|P-value:9.35E-7 ID:SGTC_2931|Compound:9014674|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.77|P-value:6.06E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.18|P-value:6.63E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.39|P-value:3.11E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.14|P-value:6.64E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.48|P-value:1.94E-4

Top fitness defect scores for YDL122W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 13.60 51.8 µM 1.83E-43 ERAD & cell cycle 12 3.83E-42
2 SGTC_188 3229-0966 7.95 278.5 µM 3.02E-16 6 9.27E-16
3 SGTC_1772 st048439 7.15 82.2 µM 1.67E-13 6 4.21E-13
4 SGTC_114 0364-0001 6.48 490.3 µM 2.08E-11 7 4.51E-11
5 SGTC_1161 k007-0610 4.97 110.0 µM 2.04E-7 ERAD & cell cycle 83 3.33E-7
6 SGTC_971 1315-0384 4.95 26.7 µM 2.31E-7 cell wall signaling 10 3.75E-7
7 SGTC_1658 st012944 4.89 20.0 µM 3.20E-7 iron homeostasis 48 5.13E-7
8 SGTC_568 1193-0097 4.82 7.5 µM 4.59E-7 ERAD & cell cycle 94 7.29E-7
9 SGTC_43 0570-0105 4.75 72.5 µM 6.34E-7 ERG2 57 9.95E-7
10 SGTC_983 1491-0821 4.54 12.2 µM 1.90E-6 6 2.88E-6
11 SGTC_143 4032-1194 4.41 15.7 µM 3.51E-6 45 5.22E-6
12 SGTC_2076 5212012 3.99 200.0 µM 2.40E-5 5 3.36E-5
13 SGTC_1464 k208-0027 3.88 110.0 µM 3.74E-5 27 5.16E-5
14 SGTC_1234 0326-0494 3.79 15.5 µM 5.44E-5 18 7.42E-5
15 SGTC_2991 9074669 3.77 71.4 µM 6.06E-5 azole & statin 73 8.23E-5
16 SGTC_2328 6201408 3.76 200.0 µM 6.15E-5 23 8.35E-5
17 SGTC_25 0118-0223 3.64 35.7 µM 1.03E-4 21 1.37E-4
18 SGTC_3219 9131112 3.56 49.5 µM 1.40E-4 Golgi 46 1.85E-4
19 SGTC_3286 9117135 3.56 37.2 µM 1.42E-4 26 1.88E-4
20 SGTC_2810 7959871 3.54 45.5 µM 1.51E-4 copper-dependent oxidative stress 53 1.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.321 7.03E-81 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.297 4.16E-69 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.272 9.27E-58 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.247 1.48E-47 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.244 1.05E-46 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.240 5.76E-45 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.213 1.13E-35 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.210 7.99E-35 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.209 2.24E-34 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.206 1.70E-33 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.205 5.93E-33 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204 1.27E-32 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.203 1.58E-32 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.197 1.24E-30 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.194 1.21E-29 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress