YDL126C / CDC48

AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL126C / CDC48

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:4.48|P-value:2.43E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:6.53|P-value:1.35E-11 ID:SGTC_38|Compound:0929-0051|FD-Score:3.81|P-value:5.05E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.57|P-value:1.63E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:4.61|P-value:1.27E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.88|P-value:3.25E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.74|P-value:6.72E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:15.60|P-value:3.35E-57 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.63|P-value:1.25E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.85|P-value:4.15E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.35|P-value:3.27E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.79|P-value:5.06E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:6.59|P-value:9.12E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:6.98|P-value:5.43E-13 ID:SGTC_192|Compound:3455-0609|FD-Score:3.85|P-value:4.20E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:-4.60|P-value:1.42E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-4.08|P-value:1.68E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.05|P-value:1.76E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.39|P-value:2.07E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:5.55|P-value:7.36E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:5.84|P-value:1.30E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:7.35|P-value:3.28E-14 ID:SGTC_606|Compound:k015-0008|FD-Score:4.62|P-value:1.19E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.19|P-value:5.64E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:4.69|P-value:8.58E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.21|P-value:5.14E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.27|P-value:6.46E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.04|P-value:9.67E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.27|P-value:6.53E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.46|P-value:2.05E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:9.11|P-value:7.73E-21 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.39|P-value:2.72E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.95|P-value:2.74E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.61|P-value:1.12E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.07|P-value:8.53E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.09|P-value:7.88E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.70|P-value:7.97E-5 ID:SGTC_1741|Compound:st038134|FD-Score:5.48|P-value:1.15E-8 ID:SGTC_1829|Compound:berberine|FD-Score:-4.36|P-value:4.59E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.45|P-value:2.17E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.58|P-value:1.47E-6 ID:SGTC_1870|Compound:st057514|FD-Score:4.91|P-value:2.75E-7 ID:SGTC_1871|Compound:st057448|FD-Score:4.04|P-value:1.82E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.26|P-value:4.32E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.49|P-value:1.82E-4 ID:SGTC_1961|Compound:st076550|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.04|P-value:9.36E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.50|P-value:9.82E-9 ID:SGTC_2067|Compound:5224629|FD-Score:3.22|P-value:5.05E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:-3.14|P-value:7.10E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-4.28|P-value:6.79E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.82|P-value:4.38E-7 ID:SGTC_2324|Compound:6149169|FD-Score:4.40|P-value:3.47E-6 ID:SGTC_2336|Compound:9001819|FD-Score:7.93|P-value:2.92E-16 ID:SGTC_2343|Compound:7990716|FD-Score:-3.67|P-value:9.27E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.15|P-value:6.52E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.20|P-value:5.66E-4 ID:SGTC_2470|Compound:5664817|FD-Score:-3.70|P-value:8.40E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.92|P-value:3.11E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.12|P-value:7.58E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.79|P-value:5.44E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.24|P-value:7.48E-6 ID:SGTC_2702|Compound:st077768|FD-Score:-3.30|P-value:4.00E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.91|P-value:3.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.14|P-value:1.28E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.20|P-value:9.21E-6 ID:SGTC_2955|Compound:9076254|FD-Score:7.67|P-value:2.66E-15 ID:SGTC_3001|Compound:9076041|FD-Score:4.06|P-value:1.73E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.67|P-value:8.90E-5 ID:SGTC_3017|Compound:9080681|FD-Score:3.15|P-value:6.46E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.09|P-value:8.30E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.07|P-value:8.88E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-5.16|P-value:7.51E-8 ID:SGTC_3299|Compound:9121982|FD-Score:4.21|P-value:8.75E-6 ID:SGTC_26|Compound:0302-0163|FD-Score:4.48|P-value:2.43E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:6.53|P-value:1.35E-11 ID:SGTC_38|Compound:0929-0051|FD-Score:3.81|P-value:5.05E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.57|P-value:1.63E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:4.61|P-value:1.27E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:4.88|P-value:3.25E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:4.74|P-value:6.72E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:15.60|P-value:3.35E-57 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.63|P-value:1.25E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:3.85|P-value:4.15E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.35|P-value:3.27E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.79|P-value:5.06E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:6.59|P-value:9.12E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:6.98|P-value:5.43E-13 ID:SGTC_192|Compound:3455-0609|FD-Score:3.85|P-value:4.20E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:-4.60|P-value:1.42E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-4.08|P-value:1.68E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.05|P-value:1.76E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.39|P-value:2.07E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:5.55|P-value:7.36E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:5.84|P-value:1.30E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:7.35|P-value:3.28E-14 ID:SGTC_606|Compound:k015-0008|FD-Score:4.62|P-value:1.19E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.19|P-value:5.64E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:4.69|P-value:8.58E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.21|P-value:5.14E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.27|P-value:6.46E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:3.04|P-value:9.67E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.27|P-value:6.53E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.46|P-value:2.05E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:9.11|P-value:7.73E-21 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.39|P-value:2.72E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.95|P-value:2.74E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.61|P-value:1.12E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.07|P-value:8.53E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.09|P-value:7.88E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.70|P-value:7.97E-5 ID:SGTC_1741|Compound:st038134|FD-Score:5.48|P-value:1.15E-8 ID:SGTC_1829|Compound:berberine|FD-Score:-4.36|P-value:4.59E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.45|P-value:2.17E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.58|P-value:1.47E-6 ID:SGTC_1870|Compound:st057514|FD-Score:4.91|P-value:2.75E-7 ID:SGTC_1871|Compound:st057448|FD-Score:4.04|P-value:1.82E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.26|P-value:4.32E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.49|P-value:1.82E-4 ID:SGTC_1961|Compound:st076550|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.04|P-value:9.36E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.50|P-value:9.82E-9 ID:SGTC_2067|Compound:5224629|FD-Score:3.22|P-value:5.05E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:-3.14|P-value:7.10E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-4.28|P-value:6.79E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.82|P-value:4.38E-7 ID:SGTC_2324|Compound:6149169|FD-Score:4.40|P-value:3.47E-6 ID:SGTC_2336|Compound:9001819|FD-Score:7.93|P-value:2.92E-16 ID:SGTC_2343|Compound:7990716|FD-Score:-3.67|P-value:9.27E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.15|P-value:6.52E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.20|P-value:5.66E-4 ID:SGTC_2470|Compound:5664817|FD-Score:-3.70|P-value:8.40E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.92|P-value:3.11E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.12|P-value:7.58E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.79|P-value:5.44E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.24|P-value:7.48E-6 ID:SGTC_2702|Compound:st077768|FD-Score:-3.30|P-value:4.00E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.91|P-value:3.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.14|P-value:1.28E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.20|P-value:9.21E-6 ID:SGTC_2955|Compound:9076254|FD-Score:7.67|P-value:2.66E-15 ID:SGTC_3001|Compound:9076041|FD-Score:4.06|P-value:1.73E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.67|P-value:8.90E-5 ID:SGTC_3017|Compound:9080681|FD-Score:3.15|P-value:6.46E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.09|P-value:8.30E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.07|P-value:8.88E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-5.16|P-value:7.51E-8 ID:SGTC_3299|Compound:9121982|FD-Score:4.21|P-value:8.75E-6

Top fitness defect scores for YDL126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_103 0844-0104 15.60 51.8 µM 3.35E-57 ERAD & cell cycle 3 4.19E-55 0.74
2 SGTC_1161 k007-0610 9.11 110.0 µM 7.73E-21 ERAD & cell cycle 5 4.17E-20 0.33
3 SGTC_2336 9001819 7.93 198.7 µM 2.92E-16 heme biosynthesis & mitochondrial translocase 16 1.06E-15 0.02
4 SGTC_2955 9076254 7.67 12.2 µM 2.66E-15 1 8.91E-15 3.05
5 SGTC_568 1193-0097 7.35 7.5 µM 3.28E-14 ERAD & cell cycle 8 1.00E-13 0.12
6 SGTC_173 1273-0061 6.98 2.7 µM 5.43E-13 mitochondrial stress 5 1.49E-12 0.59
7 SGTC_168 3970-0862 6.59 530.5 µM 9.12E-12 15 2.25E-11 0.07
8 SGTC_36 0335-0881 6.53 14.2 µM 1.35E-11 ubiquinone biosynthesis & proteasome 12 3.28E-11 0.16
9 SGTC_513 4245-1575 5.84 41.7 µM 1.30E-9 unfolded protein response 10 2.67E-9 0.03
10 SGTC_384 k007-0144 5.55 5.2 µM 7.36E-9 ERAD & cell cycle 4 1.41E-8 0.29
11 SGTC_2066 5222451 5.50 176.0 µM 9.82E-9 heme biosynthesis & mitochondrial translocase 11 1.87E-8 0.46
12 SGTC_1741 st038134 5.48 10.2 µM 1.15E-8 2 2.18E-8 1.10
13 SGTC_1870 st057514 4.91 26.5 µM 2.75E-7 RSC & ERG11 4 4.63E-7 0.31
14 SGTC_64 000l-0018 4.88 272.1 µM 3.25E-7 ubiquinone biosynthesis & proteasome 34 5.43E-7 0.14
15 SGTC_2249 haloperidol 4.82 116.4 µM 4.38E-7 ergosterol depletion effects on membrane 24 7.24E-7 0.01
16 SGTC_158 k038-0087 4.79 26.4 µM 5.06E-7 ubiquinone biosynthesis & proteasome 21 8.31E-7 0.04
17 SGTC_86 0417-1630 4.74 471.9 µM 6.72E-7 ubiquinone biosynthesis & proteasome 19 1.09E-6 0.21
18 SGTC_643 k048-0106 4.69 28.4 µM 8.58E-7 RSC & ERG11 12 1.38E-6 0.32
19 SGTC_606 k015-0008 4.62 38.6 µM 1.19E-6 2 1.89E-6 0.58
20 SGTC_42 0133-0086 4.61 60.6 µM 1.27E-6 4 2.02E-6 0.45

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.366 3.81E-107 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.354 2.48E-99 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.344 5.50E-94 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.327 1.32E-84 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.327 2.76E-84 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.311 4.52E-76 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.310 2.08E-75 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.282 3.72E-62 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.271 2.06E-57 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.267 1.15E-55 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.266 1.94E-55 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.254 1.33E-50 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.253 4.42E-50 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.250 4.14E-49 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.248 3.92E-48 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress