YDL130W / RPP1B

Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL130W / RPP1B

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:7.45|P-value:3.17E-12 ID:SGTC_69|Compound:0096-0274|FD-Score:6.42|P-value:1.62E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-7.88|P-value:2.34E-13 ID:SGTC_77|Compound:0828-0286|FD-Score:4.01|P-value:1.06E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.37|P-value:3.01E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.93|P-value:1.56E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.04|P-value:1.05E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.58|P-value:1.18E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:4.48|P-value:1.77E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.65|P-value:9.85E-6 ID:SGTC_276|Compound:colchicine|FD-Score:4.47|P-value:1.83E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.27|P-value:4.52E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.51|P-value:6.42E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.49|P-value:1.68E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.59|P-value:4.54E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.49|P-value:6.99E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.32|P-value:3.35E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:7.30|P-value:8.37E-12 ID:SGTC_432|Compound:NS 1619|FD-Score:4.42|P-value:2.27E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.51|P-value:6.60E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.74|P-value:3.02E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.45|P-value:2.22E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.35|P-value:9.80E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.36|P-value:3.23E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:4.75|P-value:5.71E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.47|P-value:6.78E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.36|P-value:9.50E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.73|P-value:3.14E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.57|P-value:5.28E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.81|P-value:2.17E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:7.86|P-value:2.12E-13 ID:SGTC_1124|Compound:fisetin|FD-Score:4.48|P-value:1.79E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.45|P-value:2.22E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-5.15|P-value:1.14E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.74|P-value:3.03E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.82|P-value:2.10E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.91|P-value:1.69E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.85|P-value:2.09E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.37|P-value:3.10E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.35|P-value:9.95E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-5.20|P-value:9.00E-7 ID:SGTC_1909|Compound:st060837|FD-Score:-3.70|P-value:3.43E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.20|P-value:5.85E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.85|P-value:2.06E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.12|P-value:7.94E-5 ID:SGTC_1950|Compound:st077106|FD-Score:5.94|P-value:2.17E-8 ID:SGTC_1953|Compound:st076800|FD-Score:6.00|P-value:1.58E-8 ID:SGTC_2002|Compound:4023503|FD-Score:-3.78|P-value:2.68E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.94|P-value:1.35E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.84|P-value:1.94E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-5.07|P-value:1.68E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.64|P-value:3.87E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.04|P-value:1.08E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.54|P-value:5.34E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.51|P-value:5.84E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.42|P-value:7.80E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.94|P-value:1.28E-13 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.45|P-value:7.09E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.03|P-value:9.91E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.01|P-value:1.07E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.39|P-value:2.49E-5 ID:SGTC_2835|Compound:9006588|FD-Score:4.62|P-value:1.00E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.36|P-value:9.37E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.04|P-value:1.07E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.62|P-value:4.47E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.59|P-value:4.50E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.57|P-value:5.44E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.55|P-value:1.48E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.73|P-value:2.81E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:7.45|P-value:3.17E-12 ID:SGTC_69|Compound:0096-0274|FD-Score:6.42|P-value:1.62E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-7.88|P-value:2.34E-13 ID:SGTC_77|Compound:0828-0286|FD-Score:4.01|P-value:1.06E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.37|P-value:3.01E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.93|P-value:1.56E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.04|P-value:1.05E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.58|P-value:1.18E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:4.48|P-value:1.77E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.65|P-value:9.85E-6 ID:SGTC_276|Compound:colchicine|FD-Score:4.47|P-value:1.83E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.27|P-value:4.52E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.51|P-value:6.42E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.49|P-value:1.68E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.59|P-value:4.54E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.49|P-value:6.99E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.32|P-value:3.35E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:7.30|P-value:8.37E-12 ID:SGTC_432|Compound:NS 1619|FD-Score:4.42|P-value:2.27E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.51|P-value:6.60E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.74|P-value:3.02E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.45|P-value:2.22E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.35|P-value:9.80E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.36|P-value:3.23E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:4.75|P-value:5.71E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.47|P-value:6.78E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.36|P-value:9.50E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.73|P-value:3.14E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:-3.57|P-value:5.28E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.81|P-value:2.17E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:7.86|P-value:2.12E-13 ID:SGTC_1124|Compound:fisetin|FD-Score:4.48|P-value:1.79E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-4.45|P-value:2.22E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-5.15|P-value:1.14E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.74|P-value:3.03E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.82|P-value:2.10E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.91|P-value:1.69E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.85|P-value:2.09E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.37|P-value:3.10E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.35|P-value:9.95E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-5.20|P-value:9.00E-7 ID:SGTC_1909|Compound:st060837|FD-Score:-3.70|P-value:3.43E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.20|P-value:5.85E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.85|P-value:2.06E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.12|P-value:7.94E-5 ID:SGTC_1950|Compound:st077106|FD-Score:5.94|P-value:2.17E-8 ID:SGTC_1953|Compound:st076800|FD-Score:6.00|P-value:1.58E-8 ID:SGTC_2002|Compound:4023503|FD-Score:-3.78|P-value:2.68E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.94|P-value:1.35E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.84|P-value:1.94E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-5.07|P-value:1.68E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.64|P-value:3.87E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.04|P-value:1.08E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.54|P-value:5.34E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.51|P-value:5.84E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.42|P-value:7.80E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.94|P-value:1.28E-13 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.45|P-value:7.09E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.03|P-value:9.91E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.01|P-value:1.07E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.39|P-value:2.49E-5 ID:SGTC_2835|Compound:9006588|FD-Score:4.62|P-value:1.00E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.36|P-value:9.37E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.04|P-value:1.07E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.62|P-value:4.47E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.59|P-value:4.50E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.57|P-value:5.44E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.55|P-value:1.48E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.73|P-value:2.81E-4

Top fitness defect scores for YDL130W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 7.94 96.7 µM 1.28E-13 calcium & mitochondrial duress 66 1.05E-15
2 SGTC_1123 mangostin 7.86 811.3 nM 2.12E-13 mitochondrial response to ROS 5 1.90E-15
3 SGTC_68 0986-0284 7.45 82.8 µM 3.17E-12 9 4.55E-14
4 SGTC_422 cantharidin 7.30 155.0 µM 8.37E-12 cell wall signaling 13 1.43E-13
5 SGTC_69 0096-0274 6.42 206.7 µM 1.62E-9 mitochondrial processes 8 6.93E-11
6 SGTC_1953 st076800 6.00 12.1 µM 1.58E-8 12 1.00E-9
7 SGTC_1950 st077106 5.94 7.2 µM 2.17E-8 RNA processing & uracil transport 6 1.46E-9
8 SGTC_872 0588-0139 4.75 234.0 µM 5.71E-6 17 9.95E-7
9 SGTC_2835 9006588 4.62 71.4 µM 1.00E-5 25 1.92E-6
10 SGTC_172 1112-0046 4.58 2.6 µM 1.18E-5 NEO1 26 2.33E-6
11 SGTC_308 4092-1169 4.49 104.0 µM 1.68E-5 plasma membrane duress 35 3.53E-6
12 SGTC_258 haloperidol 4.48 50.8 µM 1.77E-5 fatty acid desaturase (OLE1) 21 3.73E-6
13 SGTC_1124 fisetin 4.48 1.2 µM 1.79E-5 22 3.79E-6
14 SGTC_276 colchicine 4.47 750.0 µM 1.83E-5 10 3.88E-6
15 SGTC_432 NS 1619 4.42 61.3 µM 2.27E-5 20 5.01E-6
16 SGTC_2789 5281112 4.39 71.4 µM 2.49E-5 24 5.56E-6
17 SGTC_408 cantharidin 4.32 100.0 µM 3.35E-5 cell wall signaling 15 7.88E-6
18 SGTC_2725 haloperidol 4.03 53.2 µM 9.91E-5 plasma membrane duress 32 2.80E-5
19 SGTC_77 0828-0286 4.01 12.5 µM 1.06E-4 TSC3-RPN4 34 3.02E-5
20 SGTC_2782 7736369 4.01 71.4 µM 1.07E-4 39 3.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.74E-24 YNL248C RPA49 hom RNA polymerase I subunit A49
0.135 5.29E-15 YGR155W CYS4 hom Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria
0.128 8.76E-14 YDL048C STP4 hom Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress
0.126 2.53E-13 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.116 1.51E-11 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.116 1.92E-11 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.113 5.58E-11 YJR105W ADO1 hom Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.109 2.62E-10 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.108 3.62E-10 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107 4.45E-10 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.106 7.75E-10 YDL136W RPL35B hom Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.103 2.21E-9 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.103 2.62E-9 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.100 6.19E-9 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.100 7.57E-9 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS