YDL135C / RDI1

Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL135C / RDI1

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-2.92|P-value:2.91E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.78|P-value:5.31E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.17|P-value:1.03E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.91|P-value:2.94E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-4.39|P-value:1.21E-7 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.76|P-value:6.29E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.66|P-value:9.43E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.46|P-value:7.45E-8 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.36|P-value:3.65E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.39|P-value:3.18E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.97|P-value:2.62E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.00|P-value:2.25E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-2.85|P-value:3.94E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-2.75|P-value:5.95E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.87|P-value:2.92E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.66|P-value:9.24E-6 ID:SGTC_2166|Compound:5933061|FD-Score:3.21|P-value:8.55E-5 ID:SGTC_2336|Compound:9001819|FD-Score:2.86|P-value:4.07E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.73|P-value:6.34E-6 ID:SGTC_2468|Compound:5987765|FD-Score:4.74|P-value:1.39E-8 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.83|P-value:4.76E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.29|P-value:5.93E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.27|P-value:2.45E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.04|P-value:1.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.14|P-value:1.22E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.36|P-value:1.40E-7 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.67|P-value:9.12E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.08|P-value:7.68E-7 ID:SGTC_2849|Compound:9019321|FD-Score:2.98|P-value:2.47E-4 ID:SGTC_2905|Compound:7799065|FD-Score:5.57|P-value:3.54E-11 ID:SGTC_2909|Compound:7941780|FD-Score:4.26|P-value:3.06E-7 ID:SGTC_2977|Compound:9011197|FD-Score:-3.74|P-value:5.12E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.20|P-value:9.30E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-2.76|P-value:5.62E-4 ID:SGTC_3124|Compound:9127567|FD-Score:2.91|P-value:3.37E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.38|P-value:3.89E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.64|P-value:9.20E-6 ID:SGTC_3137|Compound:9097352|FD-Score:3.04|P-value:1.88E-4 ID:SGTC_3139|Compound:9095020|FD-Score:2.69|P-value:8.39E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.84|P-value:4.60E-4 ID:SGTC_3160|Compound:9100216|FD-Score:2.77|P-value:6.11E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.32|P-value:4.54E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.01|P-value:1.35E-6 ID:SGTC_3188|Compound:9110789|FD-Score:2.74|P-value:6.87E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-2.81|P-value:4.68E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.74|P-value:5.36E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.78|P-value:4.94E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-2.92|P-value:2.91E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.78|P-value:5.31E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.17|P-value:1.03E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.91|P-value:2.94E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-4.39|P-value:1.21E-7 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.76|P-value:6.29E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.66|P-value:9.43E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.46|P-value:7.45E-8 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.36|P-value:3.65E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.39|P-value:3.18E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.97|P-value:2.62E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.00|P-value:2.25E-4 ID:SGTC_1783|Compound:st039459|FD-Score:-2.85|P-value:3.94E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-2.75|P-value:5.95E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.87|P-value:2.92E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.66|P-value:9.24E-6 ID:SGTC_2166|Compound:5933061|FD-Score:3.21|P-value:8.55E-5 ID:SGTC_2336|Compound:9001819|FD-Score:2.86|P-value:4.07E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.73|P-value:6.34E-6 ID:SGTC_2468|Compound:5987765|FD-Score:4.74|P-value:1.39E-8 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.83|P-value:4.76E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.29|P-value:5.93E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.27|P-value:2.45E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.04|P-value:1.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.14|P-value:1.22E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.36|P-value:1.40E-7 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.67|P-value:9.12E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.08|P-value:7.68E-7 ID:SGTC_2849|Compound:9019321|FD-Score:2.98|P-value:2.47E-4 ID:SGTC_2905|Compound:7799065|FD-Score:5.57|P-value:3.54E-11 ID:SGTC_2909|Compound:7941780|FD-Score:4.26|P-value:3.06E-7 ID:SGTC_2977|Compound:9011197|FD-Score:-3.74|P-value:5.12E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.20|P-value:9.30E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-2.76|P-value:5.62E-4 ID:SGTC_3124|Compound:9127567|FD-Score:2.91|P-value:3.37E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.38|P-value:3.89E-5 ID:SGTC_3135|Compound:9127742|FD-Score:-3.64|P-value:9.20E-6 ID:SGTC_3137|Compound:9097352|FD-Score:3.04|P-value:1.88E-4 ID:SGTC_3139|Compound:9095020|FD-Score:2.69|P-value:8.39E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.84|P-value:4.60E-4 ID:SGTC_3160|Compound:9100216|FD-Score:2.77|P-value:6.11E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.32|P-value:4.54E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.01|P-value:1.35E-6 ID:SGTC_3188|Compound:9110789|FD-Score:2.74|P-value:6.87E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-2.81|P-value:4.68E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.74|P-value:5.36E-6 ID:SGTC_3221|Compound:9128209|FD-Score:3.78|P-value:4.94E-6

Top fitness defect scores for YDL135C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2905 7799065 5.57 20.1 µM 3.54E-11 2 1.31E-8
2 SGTC_2468 5987765 4.74 72.9 µM 1.39E-8 6 1.05E-6
3 SGTC_2909 7941780 4.26 10.5 µM 3.06E-7 16 1.02E-5
4 SGTC_3185 9108267 4.01 49.5 µM 1.35E-6 60S ribosome export 17 3.04E-5
5 SGTC_1875 nocodazole 3.87 6.0 µM 2.92E-6 tubulin folding & SWR complex 53 5.37E-5
6 SGTC_3221 9128209 3.78 49.5 µM 4.94E-6 18 7.93E-5
7 SGTC_2457 5731572 3.73 11.7 µM 6.34E-6 18 9.54E-5
8 SGTC_2042 p-Dimethylaminoacetophenone 3.66 200.0 µM 9.24E-6 26 1.26E-4
9 SGTC_3131 9127911 3.38 49.5 µM 3.89E-5 45 3.65E-4
10 SGTC_2497 7-hydroxyflavone 3.29 100.0 µM 5.93E-5 38 4.99E-4
11 SGTC_2166 5933061 3.21 31.5 µM 8.55E-5 tubulin folding & SWR complex 72 6.54E-4
12 SGTC_2985 9022375 3.20 71.4 µM 9.30E-5 RPP1 & pyrimidine depletion 60 6.97E-4
13 SGTC_435 c-PAF 3.17 6.7 µM 1.03E-4 84 7.49E-4
14 SGTC_2588 indole-3-carbinol 3.14 100.0 µM 1.22E-4 96 8.50E-4
15 SGTC_3137 9097352 3.04 49.5 µM 1.88E-4 88 0.00118
16 SGTC_2583 asiatic acid 3.04 100.0 µM 1.90E-4 72 0.00118
17 SGTC_1756 st041558 3.00 35.5 µM 2.25E-4 32 0.00134
18 SGTC_2849 9019321 2.98 13.0 µM 2.47E-4 76 0.00144
19 SGTC_1630 st005209 2.97 31.3 µM 2.62E-4 79 0.00150
20 SGTC_3124 9127567 2.91 49.5 µM 3.37E-4 DNA damage response 55 0.00182

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.67E-20 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.135 3.56E-15 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.125 3.18E-13 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.119 4.89E-12 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.116 1.88E-11 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.114 4.14E-11 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.111 1.29E-10 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.108 4.15E-10 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.105 9.53E-10 YDR156W RPA14 hom RNA polymerase I subunit A14
0.104 1.74E-9 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.100 5.68E-9 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.100 6.24E-9 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.098 1.24E-8 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.091 1.22E-7 YGR069W_d YGR069W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.44E-7 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4