YDL147W / RPN5

Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL147W / RPN5

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.96|P-value:1.80E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.35|P-value:2.26E-11 ID:SGTC_137|Compound:0438-0332|FD-Score:4.19|P-value:7.90E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.60|P-value:5.83E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.34|P-value:4.62E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.90|P-value:2.21E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.55|P-value:6.69E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.60|P-value:5.79E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.94|P-value:1.90E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.59|P-value:5.95E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.52|P-value:7.38E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.98|P-value:2.45E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.47|P-value:8.48E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.75|P-value:9.72E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.57|P-value:6.41E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.91|P-value:5.55E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:3.77|P-value:3.33E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:5.76|P-value:1.15E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:6.83|P-value:4.66E-10 ID:SGTC_623|Compound:k072-0108|FD-Score:5.09|P-value:2.38E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:5.10|P-value:2.29E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:3.53|P-value:7.11E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.63|P-value:1.55E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:7.36|P-value:2.15E-11 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.62|P-value:1.59E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.32|P-value:8.70E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.45|P-value:9.06E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.66|P-value:6.68E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.61|P-value:5.60E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.03|P-value:2.07E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.44|P-value:9.52E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.02|P-value:3.25E-8 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.12|P-value:1.03E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.52|P-value:7.28E-4 ID:SGTC_1684|Compound:st024538|FD-Score:5.78|P-value:1.05E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-4.59|P-value:2.74E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.48|P-value:2.79E-5 ID:SGTC_1751|Compound:st044839|FD-Score:4.13|P-value:9.98E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.06|P-value:1.26E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.56|P-value:2.02E-9 ID:SGTC_1871|Compound:st057448|FD-Score:3.78|P-value:3.28E-4 ID:SGTC_1962|Compound:st076595|FD-Score:4.85|P-value:6.39E-6 ID:SGTC_1968|Compound:st069590|FD-Score:3.79|P-value:3.14E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.52|P-value:7.32E-4 ID:SGTC_1972|Compound:st070201|FD-Score:4.61|P-value:1.68E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.95|P-value:1.83E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.47|P-value:8.67E-4 ID:SGTC_2124|Compound:5246320|FD-Score:9.17|P-value:1.16E-16 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.63|P-value:2.17E-7 ID:SGTC_2161|Compound:5662504|FD-Score:4.03|P-value:1.38E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.28|P-value:1.07E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.58|P-value:6.09E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.76|P-value:6.67E-10 ID:SGTC_2289|Compound:7946404|FD-Score:14.70|P-value:2.08E-39 ID:SGTC_2336|Compound:9001819|FD-Score:4.49|P-value:2.68E-5 ID:SGTC_2348|Compound:9022543|FD-Score:5.27|P-value:1.10E-6 ID:SGTC_2399|Compound:5884133|FD-Score:5.46|P-value:4.61E-7 ID:SGTC_2466|Compound:5983409|FD-Score:5.27|P-value:1.11E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:6.79|P-value:5.80E-10 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.05|P-value:1.29E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.10|P-value:2.21E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.25|P-value:6.64E-17 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.59|P-value:5.18E-12 ID:SGTC_2630|Compound:antimycin a|FD-Score:11.30|P-value:4.29E-24 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-4.32|P-value:7.62E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.40|P-value:4.64E-9 ID:SGTC_2727|Compound:riluzole|FD-Score:3.85|P-value:2.62E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.37|P-value:5.67E-9 ID:SGTC_2818|Compound:7996756|FD-Score:-3.89|P-value:3.22E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-4.00|P-value:2.27E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-7.36|P-value:4.10E-11 ID:SGTC_2963|Compound:9082507|FD-Score:3.66|P-value:4.71E-4 ID:SGTC_3142|Compound:9086498|FD-Score:7.74|P-value:2.03E-12 ID:SGTC_3317|Compound:9138495|FD-Score:3.66|P-value:4.84E-4 ID:SGTC_3318|Compound:9139014|FD-Score:5.24|P-value:1.24E-6 ID:SGTC_3324|Compound:9138759|FD-Score:4.62|P-value:1.59E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.53|P-value:7.14E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.96|P-value:1.80E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.35|P-value:2.26E-11 ID:SGTC_137|Compound:0438-0332|FD-Score:4.19|P-value:7.90E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.60|P-value:5.83E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.34|P-value:4.62E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.90|P-value:2.21E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.55|P-value:6.69E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.60|P-value:5.79E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.94|P-value:1.90E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.59|P-value:5.95E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.52|P-value:7.38E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.98|P-value:2.45E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.47|P-value:8.48E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.75|P-value:9.72E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.57|P-value:6.41E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.91|P-value:5.55E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:3.77|P-value:3.33E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:5.76|P-value:1.15E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:6.83|P-value:4.66E-10 ID:SGTC_623|Compound:k072-0108|FD-Score:5.09|P-value:2.38E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:5.10|P-value:2.29E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:3.53|P-value:7.11E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.63|P-value:1.55E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:7.36|P-value:2.15E-11 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.62|P-value:1.59E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.32|P-value:8.70E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.45|P-value:9.06E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.66|P-value:6.68E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.61|P-value:5.60E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.03|P-value:2.07E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.44|P-value:9.52E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.02|P-value:3.25E-8 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.12|P-value:1.03E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.52|P-value:7.28E-4 ID:SGTC_1684|Compound:st024538|FD-Score:5.78|P-value:1.05E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-4.59|P-value:2.74E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.48|P-value:2.79E-5 ID:SGTC_1751|Compound:st044839|FD-Score:4.13|P-value:9.98E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.06|P-value:1.26E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.56|P-value:2.02E-9 ID:SGTC_1871|Compound:st057448|FD-Score:3.78|P-value:3.28E-4 ID:SGTC_1962|Compound:st076595|FD-Score:4.85|P-value:6.39E-6 ID:SGTC_1968|Compound:st069590|FD-Score:3.79|P-value:3.14E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.52|P-value:7.32E-4 ID:SGTC_1972|Compound:st070201|FD-Score:4.61|P-value:1.68E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.95|P-value:1.83E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.47|P-value:8.67E-4 ID:SGTC_2124|Compound:5246320|FD-Score:9.17|P-value:1.16E-16 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.63|P-value:2.17E-7 ID:SGTC_2161|Compound:5662504|FD-Score:4.03|P-value:1.38E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.28|P-value:1.07E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.58|P-value:6.09E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.76|P-value:6.67E-10 ID:SGTC_2289|Compound:7946404|FD-Score:14.70|P-value:2.08E-39 ID:SGTC_2336|Compound:9001819|FD-Score:4.49|P-value:2.68E-5 ID:SGTC_2348|Compound:9022543|FD-Score:5.27|P-value:1.10E-6 ID:SGTC_2399|Compound:5884133|FD-Score:5.46|P-value:4.61E-7 ID:SGTC_2466|Compound:5983409|FD-Score:5.27|P-value:1.11E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:6.79|P-value:5.80E-10 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.05|P-value:1.29E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.10|P-value:2.21E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.25|P-value:6.64E-17 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.59|P-value:5.18E-12 ID:SGTC_2630|Compound:antimycin a|FD-Score:11.30|P-value:4.29E-24 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-4.32|P-value:7.62E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.40|P-value:4.64E-9 ID:SGTC_2727|Compound:riluzole|FD-Score:3.85|P-value:2.62E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.37|P-value:5.67E-9 ID:SGTC_2818|Compound:7996756|FD-Score:-3.89|P-value:3.22E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-4.00|P-value:2.27E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-7.36|P-value:4.10E-11 ID:SGTC_2963|Compound:9082507|FD-Score:3.66|P-value:4.71E-4 ID:SGTC_3142|Compound:9086498|FD-Score:7.74|P-value:2.03E-12 ID:SGTC_3317|Compound:9138495|FD-Score:3.66|P-value:4.84E-4 ID:SGTC_3318|Compound:9139014|FD-Score:5.24|P-value:1.24E-6 ID:SGTC_3324|Compound:9138759|FD-Score:4.62|P-value:1.59E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.53|P-value:7.14E-4

Top fitness defect scores for YDL147W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2289 7946404 14.70 165.1 µM 2.08E-39 2 5.95E-49 0.77
2 SGTC_2630 antimycin a 11.30 100.0 µM 4.29E-24 mitochondrial processes 2 1.09E-29 5.66
3 SGTC_2582 agaric acid 9.25 100.0 µM 6.64E-17 redox potentiating 8 1.16E-20 1.13
4 SGTC_2124 5246320 9.17 200.0 µM 1.16E-16 heme biosynthesis & mitochondrial translocase 9 2.32E-20 0.86
5 SGTC_3142 9086498 7.74 49.5 µM 2.03E-12 iron homeostasis 14 4.81E-15 0.09
6 SGTC_2617 dihydrotanshinone i 7.59 20.8 µM 5.18E-12 copper-dependent oxidative stress 5 1.55E-14 0.79
7 SGTC_1016 4226-1401 7.36 38.0 µM 2.15E-11 RNA pol III & RNase P/MRP 5 9.18E-14 0.61
8 SGTC_58 0957-0393 7.35 9.0 µM 2.26E-11 cell wall 22 9.81E-14 0.14
9 SGTC_576 1073-0113 6.83 22.7 µM 4.66E-10 redox potentiating 14 4.30E-12 0.24
10 SGTC_2519 cryptotanshinone 6.79 88.0 µM 5.80E-10 heme biosynthesis & mitochondrial translocase 6 5.65E-12 0.68
11 SGTC_2248 tofa 6.76 1.1 µM 6.67E-10 sphingolipid biosynthesis & PDR1 13 6.72E-12 0.38
12 SGTC_1844 rapamycin 6.56 4.0 nM 2.02E-9 20 2.68E-11 0.35
13 SGTC_2679 rapamycin 6.40 1.0 nM 4.64E-9 26 7.57E-11 0.09
14 SGTC_2790 5423970 6.37 71.4 µM 5.67E-9 endomembrane recycling 3 9.74E-11 0.37
15 SGTC_2575 plumbagin 6.10 510.0 nM 2.21E-8 superoxide 11 5.31E-10 0.01
16 SGTC_1552 6-methylflavone 6.02 10.6 µM 3.25E-8 superoxide 6 8.59E-10 0.28
17 SGTC_525 k781-2675 5.91 26.7 µM 5.55E-8 redox potentiating 23 1.67E-9 0.08
18 SGTC_1684 st024538 5.78 14.6 µM 1.05E-7 1 3.71E-9 1.26
19 SGTC_553 k007-0256 5.76 45.7 µM 1.15E-7 heme biosynthesis & mitochondrial translocase 10 4.13E-9 0.33
20 SGTC_2129 girgensonine 5.63 121.0 µM 2.17E-7 heme biosynthesis & mitochondrial translocase 11 9.11E-9 0.33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.389 8.62E-122 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.318 6.38E-80 YGL048C RPT6 het ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
0.301 2.83E-71 YOR117W RPT5 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
0.294 6.78E-68 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.287 8.72E-65 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.277 5.30E-60 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.260 3.86E-53 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.254 1.07E-50 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.240 3.70E-45 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.208 3.79E-34 YFR052W RPN12 het Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
0.197 8.59E-31 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.194 6.22E-30 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.192 4.56E-29 YFR004W RPN11 het Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress
0.192 4.60E-29 YDL097C RPN6 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
0.186 1.21E-27 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization