YDL150W / RPC53

RNA polymerase III subunit C53

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL150W / RPC53

Click on Significant Values for Screen Details ID:SGTC_104|Compound:0074-0074|FD-Score:4.48|P-value:7.75E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.05|P-value:1.85E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.56|P-value:2.00E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:6.31|P-value:4.55E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:4.50|P-value:7.39E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.57|P-value:6.32E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.72|P-value:4.27E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.30|P-value:9.36E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-5.24|P-value:1.54E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-4.70|P-value:6.14E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.84|P-value:4.35E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.41|P-value:6.83E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.81|P-value:3.48E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.21|P-value:6.25E-6 ID:SGTC_611|Compound:3453-1652|FD-Score:6.90|P-value:6.18E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:6.95|P-value:5.16E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:4.72|P-value:4.35E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.06|P-value:1.78E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.26|P-value:1.71E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:5.08|P-value:1.70E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:7.97|P-value:1.08E-8 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.65|P-value:5.08E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:7.41|P-value:9.60E-8 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.53|P-value:6.92E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.88|P-value:2.87E-4 ID:SGTC_1814|Compound:st052110|FD-Score:6.27|P-value:5.19E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-5.54|P-value:6.63E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-6.06|P-value:1.46E-5 ID:SGTC_1834|Compound:st055981|FD-Score:14.30|P-value:8.18E-24 ID:SGTC_1838|Compound:st055369|FD-Score:6.03|P-value:1.10E-5 ID:SGTC_1840|Compound:st055363|FD-Score:7.22|P-value:1.94E-7 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.54|P-value:4.80E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-6.42|P-value:4.73E-6 ID:SGTC_1915|Compound:st067105|FD-Score:14.10|P-value:3.43E-23 ID:SGTC_1930|Compound:st074634|FD-Score:13.40|P-value:3.02E-21 ID:SGTC_1950|Compound:st077106|FD-Score:6.05|P-value:1.03E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.87|P-value:2.56E-5 ID:SGTC_2057|Compound:5236571|FD-Score:11.30|P-value:1.06E-15 ID:SGTC_2071|Compound:5230951|FD-Score:4.56|P-value:6.44E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.56|P-value:6.36E-4 ID:SGTC_2156|Compound:5649887|FD-Score:6.24|P-value:5.63E-6 ID:SGTC_2172|Compound:5754775|FD-Score:4.46|P-value:8.18E-4 ID:SGTC_2306|Compound:7482397|FD-Score:8.32|P-value:2.55E-9 ID:SGTC_2330|Compound:7979373|FD-Score:6.11|P-value:8.44E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-4.87|P-value:4.04E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-6.07|P-value:1.40E-5 ID:SGTC_2393|Compound:9031399|FD-Score:12.60|P-value:4.09E-19 ID:SGTC_2411|Compound:st077133|FD-Score:8.35|P-value:2.26E-9 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.19|P-value:6.72E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:7.80|P-value:2.12E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:12.90|P-value:9.51E-20 ID:SGTC_2601|Compound:securinine|FD-Score:7.67|P-value:3.52E-8 ID:SGTC_2606|Compound:farnesol|FD-Score:5.48|P-value:5.56E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:15.50|P-value:1.30E-27 ID:SGTC_2616|Compound:abietic acid|FD-Score:-5.12|P-value:2.10E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.01|P-value:2.84E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:4.91|P-value:2.65E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:7.96|P-value:1.15E-8 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.56|P-value:8.59E-8 ID:SGTC_2785|Compound:7756463|FD-Score:4.76|P-value:3.88E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.69|P-value:6.22E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.96|P-value:2.32E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.99|P-value:2.18E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.63|P-value:5.35E-4 ID:SGTC_3136|Compound:9095672|FD-Score:6.48|P-value:2.60E-6 ID:SGTC_3141|Compound:9094609|FD-Score:-6.44|P-value:4.40E-6 ID:SGTC_3144|Compound:9087057|FD-Score:5.60|P-value:4.03E-5 ID:SGTC_3317|Compound:9138495|FD-Score:6.08|P-value:9.45E-6 ID:SGTC_104|Compound:0074-0074|FD-Score:4.48|P-value:7.75E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.05|P-value:1.85E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.56|P-value:2.00E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:6.31|P-value:4.55E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:4.50|P-value:7.39E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.57|P-value:6.32E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.72|P-value:4.27E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.30|P-value:9.36E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-5.24|P-value:1.54E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-4.70|P-value:6.14E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.84|P-value:4.35E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.41|P-value:6.83E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.81|P-value:3.48E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.21|P-value:6.25E-6 ID:SGTC_611|Compound:3453-1652|FD-Score:6.90|P-value:6.18E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:6.95|P-value:5.16E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:4.72|P-value:4.35E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.06|P-value:1.78E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.26|P-value:1.71E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:5.08|P-value:1.70E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:7.97|P-value:1.08E-8 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.65|P-value:5.08E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:7.41|P-value:9.60E-8 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.53|P-value:6.92E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.88|P-value:2.87E-4 ID:SGTC_1814|Compound:st052110|FD-Score:6.27|P-value:5.19E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-5.54|P-value:6.63E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-6.06|P-value:1.46E-5 ID:SGTC_1834|Compound:st055981|FD-Score:14.30|P-value:8.18E-24 ID:SGTC_1838|Compound:st055369|FD-Score:6.03|P-value:1.10E-5 ID:SGTC_1840|Compound:st055363|FD-Score:7.22|P-value:1.94E-7 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.54|P-value:4.80E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-6.42|P-value:4.73E-6 ID:SGTC_1915|Compound:st067105|FD-Score:14.10|P-value:3.43E-23 ID:SGTC_1930|Compound:st074634|FD-Score:13.40|P-value:3.02E-21 ID:SGTC_1950|Compound:st077106|FD-Score:6.05|P-value:1.03E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.87|P-value:2.56E-5 ID:SGTC_2057|Compound:5236571|FD-Score:11.30|P-value:1.06E-15 ID:SGTC_2071|Compound:5230951|FD-Score:4.56|P-value:6.44E-4 ID:SGTC_2113|Compound:5491891|FD-Score:4.56|P-value:6.36E-4 ID:SGTC_2156|Compound:5649887|FD-Score:6.24|P-value:5.63E-6 ID:SGTC_2172|Compound:5754775|FD-Score:4.46|P-value:8.18E-4 ID:SGTC_2306|Compound:7482397|FD-Score:8.32|P-value:2.55E-9 ID:SGTC_2330|Compound:7979373|FD-Score:6.11|P-value:8.44E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-4.87|P-value:4.04E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-6.07|P-value:1.40E-5 ID:SGTC_2393|Compound:9031399|FD-Score:12.60|P-value:4.09E-19 ID:SGTC_2411|Compound:st077133|FD-Score:8.35|P-value:2.26E-9 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.19|P-value:6.72E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:7.80|P-value:2.12E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:12.90|P-value:9.51E-20 ID:SGTC_2601|Compound:securinine|FD-Score:7.67|P-value:3.52E-8 ID:SGTC_2606|Compound:farnesol|FD-Score:5.48|P-value:5.56E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:15.50|P-value:1.30E-27 ID:SGTC_2616|Compound:abietic acid|FD-Score:-5.12|P-value:2.10E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.01|P-value:2.84E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:4.91|P-value:2.65E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:7.96|P-value:1.15E-8 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.56|P-value:8.59E-8 ID:SGTC_2785|Compound:7756463|FD-Score:4.76|P-value:3.88E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.69|P-value:6.22E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.96|P-value:2.32E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.99|P-value:2.18E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.63|P-value:5.35E-4 ID:SGTC_3136|Compound:9095672|FD-Score:6.48|P-value:2.60E-6 ID:SGTC_3141|Compound:9094609|FD-Score:-6.44|P-value:4.40E-6 ID:SGTC_3144|Compound:9087057|FD-Score:5.60|P-value:4.03E-5 ID:SGTC_3317|Compound:9138495|FD-Score:6.08|P-value:9.45E-6

Top fitness defect scores for YDL150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2612 dictamnine 15.50 15.5 µM 1.30E-27 RNA pol III & RNase P/MRP 5 2.63E-54 1.80
2 SGTC_1834 st055981 14.30 52.8 µM 8.18E-24 RPP1 & pyrimidine depletion 1 1.50E-46 6.91
3 SGTC_1915 st067105 14.10 30.6 µM 3.43E-23 RNA pol III & RNase P/MRP 4 2.79E-45 1.46
4 SGTC_1930 st074634 13.40 34.3 µM 3.02E-21 RNA pol III & RNase P/MRP 3 2.58E-41 5.05
5 SGTC_2544 sphondin 12.90 68.5 µM 9.51E-20 RNA pol III & RNase P/MRP 4 2.91E-38 2.43
6 SGTC_2393 9031399 12.60 185.9 µM 4.09E-19 RNA processing & uracil transport 1 5.68E-37 6.15
7 SGTC_2057 5236571 11.30 38.3 µM 1.06E-15 RPP1 & pyrimidine depletion 4 4.97E-30 0.44
8 SGTC_2411 st077133 8.35 39.9 µM 2.26E-9 RNA pol III & RNase P/MRP 9 3.32E-17 0.66
9 SGTC_2306 7482397 8.32 179.5 µM 2.55E-9 RPP1 & pyrimidine depletion 4 4.23E-17 2.02
10 SGTC_832 4083-0019 7.97 164.0 µM 1.08E-8 translation 2 7.77E-16 0.55
11 SGTC_2738 aclarubicin 7.96 5.5 µM 1.15E-8 RNA pol III & RNase P/MRP 3 8.84E-16 0.60
12 SGTC_2522 biochanin a 7.80 4.9 µM 2.12E-8 RNA pol III & RNase P/MRP 3 3.03E-15 0.55
13 SGTC_2601 securinine 7.67 100.0 µM 3.52E-8 2 8.35E-15 0.05
14 SGTC_1377 2944-0135 7.41 198.0 µM 9.60E-8 calcium & mitochondrial duress 1 6.29E-14 1.69
15 SGTC_800 3448-7362 7.26 155.0 µM 1.71E-7 translation 16 2.01E-13 0.48
16 SGTC_1840 st055363 7.22 71.0 µM 1.94E-7 1 2.59E-13 2.23
17 SGTC_625 k213-0058 6.95 121.0 µM 5.16E-7 translation 2 1.83E-12 0.80
18 SGTC_611 3453-1652 6.90 23.7 µM 6.18E-7 6 2.63E-12 0.27
19 SGTC_118 0083-0097 6.56 135.3 µM 2.00E-6 translation 3 2.75E-11 0.20
20 SGTC_3136 9095672 6.48 49.5 µM 2.60E-6 1 4.65E-11 2.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.457 3.20E-173 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.431 5.06E-152 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.355 2.78E-100 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.237 3.62E-44 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.221 1.88E-38 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.209 2.65E-34 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.200 1.81E-31 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.192 3.12E-29 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.186 2.31E-27 YHR062C RPP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.185 2.87E-27 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.184 4.62E-27 YNL248C RPA49 hom RNA polymerase I subunit A49
0.184 4.96E-27 YER025W GCD11 het Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
0.172 1.40E-23 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.171 2.05E-23 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.171 2.36E-23 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding