YDL155W / CLB3

B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL155W / CLB3

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-7.93|P-value:2.43E-16 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.54|P-value:1.43E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.04|P-value:1.90E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.20|P-value:8.28E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.22|P-value:5.33E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.71|P-value:7.83E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.71|P-value:7.04E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.03|P-value:1.50E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.21|P-value:5.36E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.09|P-value:8.31E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.79|P-value:5.77E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.60|P-value:1.35E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:3.08|P-value:8.69E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.75|P-value:6.65E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-12.50|P-value:5.47E-38 ID:SGTC_826|Compound:1683-5028|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.04|P-value:9.08E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.50|P-value:2.30E-6 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.96|P-value:2.74E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.27|P-value:6.74E-6 ID:SGTC_1683|Compound:st010134|FD-Score:3.87|P-value:4.09E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.19|P-value:5.94E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.51|P-value:1.59E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.27|P-value:6.71E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.52|P-value:1.68E-4 ID:SGTC_2480|Compound:5767542|FD-Score:4.45|P-value:2.84E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-4.93|P-value:2.17E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.26|P-value:4.54E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.16|P-value:6.03E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.46|P-value:1.92E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.78|P-value:6.04E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.19|P-value:1.01E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.23|P-value:5.05E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.05|P-value:9.60E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.05|P-value:9.58E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.30|P-value:3.57E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.55|P-value:1.49E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.54|P-value:1.56E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.38|P-value:2.93E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-7.93|P-value:2.43E-16 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.54|P-value:1.43E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.13|P-value:7.26E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.04|P-value:1.90E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.20|P-value:8.28E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:3.22|P-value:5.33E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.71|P-value:7.83E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.71|P-value:7.04E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.03|P-value:1.50E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.21|P-value:5.36E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.09|P-value:8.31E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.79|P-value:5.77E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.60|P-value:1.35E-6 ID:SGTC_686|Compound:1319-0111|FD-Score:3.08|P-value:8.69E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.75|P-value:6.65E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-12.50|P-value:5.47E-38 ID:SGTC_826|Compound:1683-5028|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.60|P-value:1.23E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.04|P-value:9.08E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.50|P-value:2.30E-6 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.96|P-value:2.74E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.27|P-value:6.74E-6 ID:SGTC_1683|Compound:st010134|FD-Score:3.87|P-value:4.09E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.19|P-value:5.94E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.51|P-value:1.59E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.27|P-value:6.71E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.52|P-value:1.68E-4 ID:SGTC_2480|Compound:5767542|FD-Score:4.45|P-value:2.84E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-4.93|P-value:2.17E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.26|P-value:4.54E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.16|P-value:6.03E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.46|P-value:1.92E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.78|P-value:6.04E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.19|P-value:1.01E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.23|P-value:5.05E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.05|P-value:9.60E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.05|P-value:9.58E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.30|P-value:3.57E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.55|P-value:1.49E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.54|P-value:1.56E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.38|P-value:2.93E-4

Top fitness defect scores for YDL155W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 5.03 2.6 nM 1.50E-7 cell wall 104 2.49E-7
2 SGTC_669 0108-0021 4.60 26.2 µM 1.35E-6 fatty acid desaturase (OLE1) 53 2.06E-6
3 SGTC_996 3970-0799 4.50 1.8 µM 2.30E-6 63 3.44E-6
4 SGTC_2480 5767542 4.45 37.2 µM 2.84E-6 6 4.21E-6
5 SGTC_2275 7947463 4.27 200.0 µM 6.71E-6 iron homeostasis 31 9.63E-6
6 SGTC_1580 hydrocortisone 21-hemisuccinate 4.27 43.2 µM 6.74E-6 19 9.67E-6
7 SGTC_2954 9074818 4.19 52.7 µM 1.01E-5 32 1.42E-5
8 SGTC_225 nsc-122657 4.04 1.0 µM 1.90E-5 10 2.62E-5
9 SGTC_1413 3910-0535 3.96 34.4 µM 2.74E-5 13 3.73E-5
10 SGTC_1683 st010134 3.87 710.0 nM 4.09E-5 31 5.48E-5
11 SGTC_654 1124-0271 3.79 80.9 µM 5.77E-5 25 7.64E-5
12 SGTC_2917 7979103 3.78 53.8 µM 6.04E-5 34 7.99E-5
13 SGTC_757 1066-0008 3.75 322.0 µM 6.65E-5 Golgi 22 8.76E-5
14 SGTC_453 enantio-paf c16 3.71 10.0 µM 7.83E-5 163 1.03E-4
15 SGTC_861 0443-0273 3.60 110.0 µM 1.23E-4 17 1.59E-4
16 SGTC_3311 9131146 3.55 2.9 µM 1.49E-4 cell wall 137 1.91E-4
17 SGTC_3338 9144300 3.54 39.6 µM 1.56E-4 Golgi 37 1.99E-4
18 SGTC_2332 7982454 3.52 138.9 µM 1.68E-4 71 2.14E-4
19 SGTC_3339 9145883 3.38 14.9 µM 2.93E-4 28 3.66E-4
20 SGTC_2763 lisinopril 3.26 49.3 µM 4.54E-4 24 5.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.374 7.93E-112 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.322 6.31E-82 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.313 4.60E-77 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.294 9.31E-68 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.282 1.56E-62 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.253 5.68E-50 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.245 8.35E-47 YDR242W AMD2 hom Putative amidase
0.242 8.98E-46 YGR018C_p YGR018C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W
0.241 1.49E-45 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.240 2.80E-45 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.239 1.26E-44 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.234 3.62E-43 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.227 1.99E-40 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.218 2.26E-37 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.213 7.52E-36 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress