YDL167C / NRP1

Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL167C / NRP1

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.35|P-value:6.55E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.98|P-value:6.48E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:12.80|P-value:1.01E-34 ID:SGTC_190|Compound:3970-0790|FD-Score:3.28|P-value:8.22E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.33|P-value:1.60E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:4.29|P-value:1.93E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.27|P-value:8.29E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.24|P-value:9.60E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.71|P-value:1.90E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.48|P-value:4.22E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.15|P-value:3.49E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.79|P-value:1.40E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.90|P-value:9.25E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.31|P-value:7.46E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.69|P-value:2.39E-8 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.38|P-value:5.74E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.28|P-value:8.34E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.47|P-value:4.35E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.32|P-value:7.32E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.16|P-value:3.32E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.41|P-value:5.31E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.72|P-value:1.78E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.82|P-value:1.23E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.19|P-value:2.95E-5 ID:SGTC_1712|Compound:st032288|FD-Score:7.13|P-value:3.98E-12 ID:SGTC_1754|Compound:st042065|FD-Score:6.38|P-value:4.77E-10 ID:SGTC_1760|Compound:st045453|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.33|P-value:1.57E-7 ID:SGTC_1818|Compound:st052136|FD-Score:4.75|P-value:2.63E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.11|P-value:4.54E-7 ID:SGTC_1933|Compound:st074711|FD-Score:3.29|P-value:8.03E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.36|P-value:6.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.25|P-value:2.28E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-4.10|P-value:4.13E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.38|P-value:1.36E-5 ID:SGTC_2195|Compound:6536160|FD-Score:4.66|P-value:3.95E-6 ID:SGTC_2231|Compound:micatex|FD-Score:4.36|P-value:1.42E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.11|P-value:4.86E-7 ID:SGTC_2466|Compound:5983409|FD-Score:5.31|P-value:1.78E-7 ID:SGTC_2471|Compound:5466956|FD-Score:-5.31|P-value:1.64E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-3.51|P-value:3.74E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.00|P-value:6.15E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.53|P-value:6.59E-6 ID:SGTC_2862|Compound:9027634|FD-Score:3.35|P-value:6.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.66|P-value:3.91E-6 ID:SGTC_3037|Compound:9091026|FD-Score:4.48|P-value:8.73E-6 ID:SGTC_3142|Compound:9086498|FD-Score:4.43|P-value:1.06E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:3.35|P-value:6.55E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.98|P-value:6.48E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:12.80|P-value:1.01E-34 ID:SGTC_190|Compound:3970-0790|FD-Score:3.28|P-value:8.22E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.33|P-value:1.60E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:4.29|P-value:1.93E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.27|P-value:8.29E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.24|P-value:9.60E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.71|P-value:1.90E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.48|P-value:4.22E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.15|P-value:3.49E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.79|P-value:1.40E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.90|P-value:9.25E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.31|P-value:7.46E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.69|P-value:2.39E-8 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.38|P-value:5.74E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.28|P-value:8.34E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.47|P-value:4.35E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.32|P-value:7.32E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.16|P-value:3.32E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.41|P-value:5.31E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.72|P-value:1.78E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.82|P-value:1.23E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.19|P-value:2.95E-5 ID:SGTC_1712|Compound:st032288|FD-Score:7.13|P-value:3.98E-12 ID:SGTC_1754|Compound:st042065|FD-Score:6.38|P-value:4.77E-10 ID:SGTC_1760|Compound:st045453|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.33|P-value:1.57E-7 ID:SGTC_1818|Compound:st052136|FD-Score:4.75|P-value:2.63E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.11|P-value:4.54E-7 ID:SGTC_1933|Compound:st074711|FD-Score:3.29|P-value:8.03E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.36|P-value:6.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.25|P-value:2.28E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-4.10|P-value:4.13E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.38|P-value:1.36E-5 ID:SGTC_2195|Compound:6536160|FD-Score:4.66|P-value:3.95E-6 ID:SGTC_2231|Compound:micatex|FD-Score:4.36|P-value:1.42E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.11|P-value:4.86E-7 ID:SGTC_2466|Compound:5983409|FD-Score:5.31|P-value:1.78E-7 ID:SGTC_2471|Compound:5466956|FD-Score:-5.31|P-value:1.64E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-3.51|P-value:3.74E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.00|P-value:6.15E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.53|P-value:6.59E-6 ID:SGTC_2862|Compound:9027634|FD-Score:3.35|P-value:6.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.66|P-value:3.91E-6 ID:SGTC_3037|Compound:9091026|FD-Score:4.48|P-value:8.73E-6 ID:SGTC_3142|Compound:9086498|FD-Score:4.43|P-value:1.06E-5

Top fitness defect scores for YDL167C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_178 4092-0806 12.80 87.5 µM 1.01E-34 ergosterol depletion effects on membrane 6 1.56E-37
2 SGTC_1712 st032288 7.13 53.4 µM 3.98E-12 calcium & mitochondrial duress 52 5.06E-13
3 SGTC_1754 st042065 6.38 16.1 µM 4.77E-10 NEO1-PIK1 86 9.05E-11
4 SGTC_1230 0170-0365 5.69 3.8 µM 2.39E-8 endomembrane recycling 25 6.29E-9
5 SGTC_1800 st050079 5.33 29.1 µM 1.57E-7 NEO1-PIK1 63 4.84E-8
6 SGTC_197 4544-0043 5.33 41.6 µM 1.60E-7 endomembrane recycling 22 4.95E-8
7 SGTC_2466 5983409 5.31 37.1 µM 1.78E-7 5 5.56E-8
8 SGTC_2385 9074692 5.11 200.0 µM 4.86E-7 18 1.64E-7
9 SGTC_1818 st052136 4.75 56.3 µM 2.63E-6 NEO1-PIK1 25 1.02E-6
10 SGTC_2896 9052656 4.66 71.4 µM 3.91E-6 endomembrane recycling 72 1.57E-6
11 SGTC_2195 6536160 4.66 144.2 µM 3.95E-6 60S ribosome export 4 1.59E-6
12 SGTC_3037 9091026 4.48 49.5 µM 8.73E-6 NEO1-PIK1 93 3.75E-6
13 SGTC_3142 9086498 4.43 49.5 µM 1.06E-5 iron homeostasis 24 4.63E-6
14 SGTC_2092 5303694 4.38 80.7 µM 1.36E-5 TSC3-RPN4 29 6.06E-6
15 SGTC_2231 micatex 4.36 6.8 µM 1.42E-5 11 6.37E-6
16 SGTC_245 methotrexate 4.29 289.6 µM 1.93E-5 36 8.84E-6
17 SGTC_2021 4019055 4.25 173.0 µM 2.28E-5 endomembrane recycling 105 1.06E-5
18 SGTC_1627 st003713 4.19 25.6 µM 2.95E-5 calcium & mitochondrial duress 62 1.40E-5
19 SGTC_1363 1636-0063 4.16 10.4 µM 3.32E-5 Golgi 24 1.59E-5
20 SGTC_1051 3253-3903 4.15 78.0 µM 3.49E-5 19 1.68E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 1.76E-55 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.258 4.85E-52 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.245 6.69E-47 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.244 1.02E-46 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.243 3.21E-46 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.241 1.66E-45 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.239 8.57E-45 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.239 1.02E-44 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.237 3.24E-44 YGL043W DST1 hom General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
0.226 2.85E-40 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.224 2.37E-39 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.223 3.78E-39 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.223 5.21E-39 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.217 5.99E-37 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.215 2.21E-36 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction