YDL176W

Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL176W / YDL176W

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-3.34|P-value:7.71E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.79|P-value:2.89E-8 ID:SGTC_152|Compound:4469-0003|FD-Score:2.81|P-value:7.20E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:2.75|P-value:9.06E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.12|P-value:2.07E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.03|P-value:2.92E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.02|P-value:6.44E-9 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.61|P-value:2.08E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:4.06|P-value:2.08E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.35|P-value:7.43E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.74|P-value:9.28E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.63|P-value:1.94E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.02|P-value:3.07E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.78|P-value:8.14E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:2.87|P-value:5.57E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-5.39|P-value:4.97E-10 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.82|P-value:4.51E-29 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.05|P-value:3.75E-12 ID:SGTC_1674|Compound:st016616|FD-Score:2.88|P-value:5.47E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.33|P-value:7.89E-5 ID:SGTC_1729|Compound:st035615|FD-Score:2.78|P-value:7.99E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.69|P-value:1.40E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.91|P-value:4.56E-6 ID:SGTC_1798|Compound:st045719|FD-Score:3.07|P-value:2.50E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-2.79|P-value:7.78E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.78|P-value:9.33E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-2.96|P-value:3.93E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-2.91|P-value:4.90E-4 ID:SGTC_2218|Compound:6965428|FD-Score:2.75|P-value:9.07E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.12|P-value:1.47E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:2.84|P-value:6.27E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-2.77|P-value:8.71E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.06|P-value:2.67E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.14|P-value:1.89E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.73|P-value:9.74E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.87|P-value:5.60E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.00|P-value:3.33E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.40|P-value:5.78E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.78|P-value:8.21E-4 ID:SGTC_3171|Compound:9103192|FD-Score:-3.10|P-value:2.28E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-4.95|P-value:1.04E-8 ID:SGTC_3200|Compound:9114385|FD-Score:3.98|P-value:3.26E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-3.06|P-value:2.63E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.04|P-value:2.85E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.73|P-value:1.21E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.34|P-value:7.71E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.79|P-value:2.89E-8 ID:SGTC_152|Compound:4469-0003|FD-Score:2.81|P-value:7.20E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:2.75|P-value:9.06E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.12|P-value:2.07E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.03|P-value:2.92E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.02|P-value:6.44E-9 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.61|P-value:2.08E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:4.06|P-value:2.08E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.35|P-value:7.43E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.74|P-value:9.28E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.63|P-value:1.94E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.02|P-value:3.07E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.78|P-value:8.14E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:2.87|P-value:5.57E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-5.39|P-value:4.97E-10 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.82|P-value:4.51E-29 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.05|P-value:3.75E-12 ID:SGTC_1674|Compound:st016616|FD-Score:2.88|P-value:5.47E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.33|P-value:7.89E-5 ID:SGTC_1729|Compound:st035615|FD-Score:2.78|P-value:7.99E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.69|P-value:1.40E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.91|P-value:4.56E-6 ID:SGTC_1798|Compound:st045719|FD-Score:3.07|P-value:2.50E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-2.79|P-value:7.78E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.78|P-value:9.33E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-2.96|P-value:3.93E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-2.91|P-value:4.90E-4 ID:SGTC_2218|Compound:6965428|FD-Score:2.75|P-value:9.07E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.12|P-value:1.47E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:2.84|P-value:6.27E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-2.77|P-value:8.71E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.06|P-value:2.67E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.14|P-value:1.89E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.73|P-value:9.74E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.87|P-value:5.60E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.00|P-value:3.33E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.40|P-value:5.78E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.78|P-value:8.21E-4 ID:SGTC_3171|Compound:9103192|FD-Score:-3.10|P-value:2.28E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-4.95|P-value:1.04E-8 ID:SGTC_3200|Compound:9114385|FD-Score:3.98|P-value:3.26E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-3.06|P-value:2.63E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.04|P-value:2.85E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.73|P-value:1.21E-5

Top fitness defect scores for YDL176W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_515 4092-1064 5.02 102.0 µM 6.44E-9 plasma membrane duress 38 2.63E-7
2 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.12 100.0 µM 1.47E-6 20 1.86E-5
3 SGTC_1117 retinoic acid 4.06 1.1 µM 2.08E-6 13 2.45E-5
4 SGTC_3200 9114385 3.98 49.5 µM 3.26E-6 35 3.50E-5
5 SGTC_1749 st037932 3.91 54.2 µM 4.56E-6 28 4.56E-5
6 SGTC_2002 4023503 3.78 131.0 µM 9.33E-6 mitochondrial processes 39 8.00E-5
7 SGTC_1739 st037196 3.69 92.5 µM 1.40E-5 31 1.10E-4
8 SGTC_1230 0170-0365 3.63 3.8 µM 1.94E-5 endomembrane recycling 85 1.42E-4
9 SGTC_1007 4101-0031 3.61 70.0 µM 2.08E-5 26 1.51E-4
10 SGTC_3047 9092122 3.40 49.5 µM 5.78E-5 41 3.37E-4
11 SGTC_1693 xanthone 3.33 101.9 µM 7.89E-5 DNA damage response 31 4.31E-4
12 SGTC_1798 st045719 3.07 61.0 µM 2.50E-4 27 0.00107
13 SGTC_3228 9131799 3.04 49.5 µM 2.85E-4 amide catabolism 28 0.00119
14 SGTC_273 hydroxyurea 3.03 18.1 mM 2.92E-4 heme biosynthesis & mitochondrial translocase 68 0.00121
15 SGTC_1261 0712-0010 3.02 12.7 µM 3.07E-4 RNA processing & uracil transport 65 0.00126
16 SGTC_3039 9090270 3.00 49.5 µM 3.33E-4 RPP1 & pyrimidine depletion 38 0.00135
17 SGTC_1674 st016616 2.88 23.6 µM 5.47E-4 79 0.00200
18 SGTC_1323 1348-1351 2.87 11.2 µM 5.57E-4 47 0.00202
19 SGTC_2987 9018338 2.87 71.4 µM 5.60E-4 RPP1 & pyrimidine depletion 85 0.00203
20 SGTC_2596 sinensetin 2.84 100.0 µM 6.27E-4 84 0.00222

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.435 1.70E-154 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.428 1.30E-149 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.397 4.68E-126 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.396 6.51E-126 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.387 2.27E-120 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.375 3.14E-112 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.375 4.74E-112 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.344 1.72E-93 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.342 1.08E-92 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.321 4.16E-81 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.316 1.03E-78 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.306 8.15E-74 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.294 1.40E-67 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.291 3.78E-66 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.288 5.64E-65 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress