YDL180W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL180W / YDL180W

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-3.02|P-value:8.59E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.70|P-value:8.35E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.64|P-value:3.70E-12 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.06|P-value:7.66E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.07|P-value:7.35E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.42|P-value:2.52E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.24|P-value:4.98E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.95|P-value:2.19E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:3.36|P-value:3.16E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.09|P-value:8.44E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.03|P-value:8.54E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.46|P-value:2.18E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.75|P-value:6.63E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.00|P-value:9.25E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.57|P-value:1.09E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:4.13|P-value:1.30E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.93|P-value:2.42E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.63|P-value:1.11E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.29|P-value:4.14E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.21|P-value:4.40E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.24|P-value:4.89E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.47|P-value:2.09E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.30|P-value:3.20E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.25|P-value:4.77E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.11|P-value:7.92E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.51|P-value:1.40E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.35|P-value:2.63E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.05|P-value:7.83E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.32|P-value:5.31E-6 ID:SGTC_1714|Compound:st033236|FD-Score:3.14|P-value:7.13E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.22|P-value:5.22E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.98|P-value:9.92E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-3.26|P-value:3.68E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.02|P-value:8.68E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.84|P-value:4.61E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.05|P-value:9.73E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.83|P-value:3.69E-5 ID:SGTC_2537|Compound:larixol|FD-Score:5.44|P-value:1.44E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.04|P-value:1.90E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.56|P-value:1.45E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.10|P-value:8.13E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.17|P-value:5.18E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.81|P-value:5.20E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.59|P-value:1.29E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.02|P-value:8.59E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.70|P-value:8.35E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.64|P-value:3.70E-12 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.06|P-value:7.66E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.07|P-value:7.35E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.36|P-value:3.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.42|P-value:2.52E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.24|P-value:4.98E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.95|P-value:2.19E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:3.36|P-value:3.16E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:3.09|P-value:8.44E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.03|P-value:8.54E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.46|P-value:2.18E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.75|P-value:6.63E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.00|P-value:9.25E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.57|P-value:1.09E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:4.13|P-value:1.30E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.93|P-value:2.42E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.63|P-value:1.11E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.29|P-value:4.14E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.21|P-value:4.40E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.24|P-value:4.89E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.47|P-value:2.09E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.30|P-value:3.20E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.25|P-value:4.77E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.11|P-value:7.92E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.51|P-value:1.40E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.35|P-value:2.63E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.05|P-value:7.83E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.32|P-value:5.31E-6 ID:SGTC_1714|Compound:st033236|FD-Score:3.14|P-value:7.13E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.22|P-value:5.22E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.98|P-value:9.92E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-3.26|P-value:3.68E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.02|P-value:8.68E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.84|P-value:4.61E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.05|P-value:9.73E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.83|P-value:3.69E-5 ID:SGTC_2537|Compound:larixol|FD-Score:5.44|P-value:1.44E-8 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.04|P-value:1.90E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.56|P-value:1.45E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.10|P-value:8.13E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.17|P-value:5.18E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.81|P-value:5.20E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.59|P-value:1.29E-4

Top fitness defect scores for YDL180W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2537 larixol 5.44 68.9 µM 1.44E-8 8 2.74E-8
2 SGTC_1401 3807-4679 4.32 7.6 µM 5.31E-6 tubulin folding & SWR complex 14 7.79E-6
3 SGTC_688 0527-0193 4.13 473.0 µM 1.30E-5 fatty acid desaturase (OLE1) 10 1.84E-5
4 SGTC_2567 aureobasidin a 4.04 60.0 nM 1.90E-5 91 2.64E-5
5 SGTC_2316 5844804 3.84 197.4 µM 4.61E-5 35 6.17E-5
6 SGTC_3277 9138724 3.81 49.5 µM 5.20E-5 Golgi 26 6.93E-5
7 SGTC_669 0108-0021 3.75 26.2 µM 6.63E-5 fatty acid desaturase (OLE1) 91 8.75E-5
8 SGTC_28 pentachloropyridine N-oxide 3.70 1.6 µM 8.35E-5 TSC3-RPN4 85 1.09E-4
9 SGTC_930 2810-3379 3.63 265.0 µM 1.11E-4 17 1.43E-4
10 SGTC_3300 9124615 3.59 50.5 µM 1.29E-4 29 1.66E-4
11 SGTC_2586 curcumin 3.56 80.0 µM 1.45E-4 iron homeostasis 72 1.85E-4
12 SGTC_3042 9091578 3.55 49.5 µM 1.53E-4 ERG2 5 1.95E-4
13 SGTC_2847 9005661 3.49 71.4 µM 1.91E-4 11 2.41E-4
14 SGTC_2514 salinomycin 3.49 42.7 µM 1.94E-4 73 2.44E-4
15 SGTC_1125 tnp00248 3.47 1.3 µM 2.09E-4 55 2.63E-4
16 SGTC_640 3381-0960 3.46 37.1 µM 2.18E-4 29 2.74E-4
17 SGTC_374 0880-0231 3.42 82.3 µM 2.52E-4 iron homeostasis 43 3.14E-4
18 SGTC_315 k915-0449 3.36 187.0 µM 3.12E-4 78 3.87E-4
19 SGTC_521 r062-0005 3.36 13.8 µM 3.16E-4 29 3.91E-4
20 SGTC_1216 1165-0504 3.30 9.7 µM 3.98E-4 34 4.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.26E-20 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.155 2.10E-19 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.140 3.45E-16 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.124 5.10E-13 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.121 1.67E-12 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.118 7.31E-12 YDL084W SUB2 het Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.118 8.35E-12 YLR137W RKM5 hom Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species
0.117 9.70E-12 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.116 1.60E-11 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
0.115 2.64E-11 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.114 3.42E-11 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.114 3.92E-11 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.112 6.53E-11 YMR023C MSS1 hom Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
0.109 2.48E-10 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.106 7.26E-10 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene