YDL192W / ARF1

ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL192W / ARF1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.06|P-value:1.53E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.54|P-value:8.09E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:9.71|P-value:2.38E-18 ID:SGTC_73|Compound:0327-0325|FD-Score:-7.43|P-value:1.47E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:6.11|P-value:2.59E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:8.44|P-value:2.67E-14 ID:SGTC_197|Compound:4544-0043|FD-Score:6.86|P-value:4.92E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:3.90|P-value:2.62E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.56|P-value:7.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.28|P-value:6.34E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:18.40|P-value:6.32E-61 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.74|P-value:1.23E-5 ID:SGTC_447|Compound:ml7|FD-Score:3.99|P-value:1.91E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.49|P-value:1.04E-11 ID:SGTC_459|Compound:nigericin|FD-Score:7.00|P-value:2.19E-10 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.58|P-value:7.30E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:7.10|P-value:1.27E-10 ID:SGTC_527|Compound:4476-4215|FD-Score:4.56|P-value:2.44E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:11.40|P-value:1.22E-24 ID:SGTC_582|Compound:0987-0078|FD-Score:3.86|P-value:2.97E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.62|P-value:6.43E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.29|P-value:6.69E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-5.02|P-value:3.42E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:4.49|P-value:3.22E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:4.31|P-value:6.21E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:12.80|P-value:1.07E-30 ID:SGTC_863|Compound:0466-0191|FD-Score:4.90|P-value:6.46E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.72|P-value:4.27E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.53|P-value:8.44E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.39|P-value:4.65E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.25|P-value:1.49E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.37|P-value:7.01E-9 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.71|P-value:4.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.42|P-value:7.08E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:8.39|P-value:3.77E-14 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.45|P-value:3.74E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.53|P-value:8.49E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.24|P-value:7.95E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.89|P-value:2.69E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.73|P-value:4.49E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:11.80|P-value:2.24E-26 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.85|P-value:3.07E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.80|P-value:3.60E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.25|P-value:1.26E-8 ID:SGTC_1666|Compound:st014829|FD-Score:9.68|P-value:3.16E-18 ID:SGTC_1687|Compound:st020778|FD-Score:21.70|P-value:1.39E-83 ID:SGTC_1712|Compound:st032288|FD-Score:6.38|P-value:6.45E-9 ID:SGTC_1744|Compound:st037937|FD-Score:4.22|P-value:8.62E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.45|P-value:9.88E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:15.00|P-value:3.84E-41 ID:SGTC_1874|Compound:staurosporine|FD-Score:8.69|P-value:4.70E-15 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.23|P-value:8.34E-5 ID:SGTC_1921|Compound:5740136|FD-Score:5.35|P-value:9.67E-7 ID:SGTC_1922|Compound:5578187|FD-Score:3.62|P-value:6.35E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.79|P-value:3.69E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.96|P-value:2.16E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.12|P-value:1.23E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.56|P-value:7.70E-4 ID:SGTC_2077|Compound:5212015|FD-Score:7.34|P-value:3.02E-11 ID:SGTC_2200|Compound:6600604|FD-Score:8.08|P-value:3.01E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.20|P-value:8.50E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.37|P-value:2.50E-11 ID:SGTC_2255|Compound:7941087|FD-Score:-3.54|P-value:7.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.71|P-value:1.39E-5 ID:SGTC_2262|Compound:9014885|FD-Score:-4.07|P-value:1.31E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.84|P-value:8.12E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.84|P-value:8.32E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.91|P-value:6.19E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:3.62|P-value:6.48E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.51|P-value:3.01E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.70|P-value:1.44E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.37|P-value:8.71E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:30.00|P-value:4.74E-158 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.21|P-value:8.02E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.76|P-value:2.84E-15 ID:SGTC_2661|Compound:dactinomycin|FD-Score:6.76|P-value:8.36E-10 ID:SGTC_2737|Compound:bleomycin|FD-Score:11.40|P-value:1.65E-24 ID:SGTC_2786|Compound:7743617|FD-Score:4.04|P-value:1.64E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.68|P-value:1.41E-5 ID:SGTC_2830|Compound:7992007|FD-Score:4.08|P-value:1.43E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-4.30|P-value:5.82E-5 ID:SGTC_2841|Compound:9004761|FD-Score:5.29|P-value:1.25E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.45|P-value:3.36E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.72|P-value:4.71E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.06|P-value:1.53E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.54|P-value:8.09E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:9.71|P-value:2.38E-18 ID:SGTC_73|Compound:0327-0325|FD-Score:-7.43|P-value:1.47E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:6.11|P-value:2.59E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:8.44|P-value:2.67E-14 ID:SGTC_197|Compound:4544-0043|FD-Score:6.86|P-value:4.92E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:3.90|P-value:2.62E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.56|P-value:7.74E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.28|P-value:6.34E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:18.40|P-value:6.32E-61 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.74|P-value:1.23E-5 ID:SGTC_447|Compound:ml7|FD-Score:3.99|P-value:1.91E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.49|P-value:1.04E-11 ID:SGTC_459|Compound:nigericin|FD-Score:7.00|P-value:2.19E-10 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.58|P-value:7.30E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:7.10|P-value:1.27E-10 ID:SGTC_527|Compound:4476-4215|FD-Score:4.56|P-value:2.44E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:11.40|P-value:1.22E-24 ID:SGTC_582|Compound:0987-0078|FD-Score:3.86|P-value:2.97E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.62|P-value:6.43E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.29|P-value:6.69E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-5.02|P-value:3.42E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:4.49|P-value:3.22E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:4.31|P-value:6.21E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:12.80|P-value:1.07E-30 ID:SGTC_863|Compound:0466-0191|FD-Score:4.90|P-value:6.46E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.72|P-value:4.27E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.53|P-value:8.44E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.39|P-value:4.65E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.25|P-value:1.49E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.37|P-value:7.01E-9 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.71|P-value:4.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:5.42|P-value:7.08E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:8.39|P-value:3.77E-14 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.45|P-value:3.74E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.53|P-value:8.49E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.24|P-value:7.95E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.89|P-value:2.69E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.73|P-value:4.49E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:11.80|P-value:2.24E-26 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.85|P-value:3.07E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.80|P-value:3.60E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.25|P-value:1.26E-8 ID:SGTC_1666|Compound:st014829|FD-Score:9.68|P-value:3.16E-18 ID:SGTC_1687|Compound:st020778|FD-Score:21.70|P-value:1.39E-83 ID:SGTC_1712|Compound:st032288|FD-Score:6.38|P-value:6.45E-9 ID:SGTC_1744|Compound:st037937|FD-Score:4.22|P-value:8.62E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-3.45|P-value:9.88E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:15.00|P-value:3.84E-41 ID:SGTC_1874|Compound:staurosporine|FD-Score:8.69|P-value:4.70E-15 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.23|P-value:8.34E-5 ID:SGTC_1921|Compound:5740136|FD-Score:5.35|P-value:9.67E-7 ID:SGTC_1922|Compound:5578187|FD-Score:3.62|P-value:6.35E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.79|P-value:3.69E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.96|P-value:2.16E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.12|P-value:1.23E-4 ID:SGTC_2072|Compound:5231554|FD-Score:3.56|P-value:7.70E-4 ID:SGTC_2077|Compound:5212015|FD-Score:7.34|P-value:3.02E-11 ID:SGTC_2200|Compound:6600604|FD-Score:8.08|P-value:3.01E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.20|P-value:8.50E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.37|P-value:2.50E-11 ID:SGTC_2255|Compound:7941087|FD-Score:-3.54|P-value:7.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.71|P-value:1.39E-5 ID:SGTC_2262|Compound:9014885|FD-Score:-4.07|P-value:1.31E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.84|P-value:8.12E-6 ID:SGTC_2368|Compound:9071271|FD-Score:4.84|P-value:8.32E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.91|P-value:6.19E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:3.62|P-value:6.48E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:4.51|P-value:3.01E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.70|P-value:1.44E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.37|P-value:8.71E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:30.00|P-value:4.74E-158 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.21|P-value:8.02E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:8.76|P-value:2.84E-15 ID:SGTC_2661|Compound:dactinomycin|FD-Score:6.76|P-value:8.36E-10 ID:SGTC_2737|Compound:bleomycin|FD-Score:11.40|P-value:1.65E-24 ID:SGTC_2786|Compound:7743617|FD-Score:4.04|P-value:1.64E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.68|P-value:1.41E-5 ID:SGTC_2830|Compound:7992007|FD-Score:4.08|P-value:1.43E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-4.30|P-value:5.82E-5 ID:SGTC_2841|Compound:9004761|FD-Score:5.29|P-value:1.25E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.45|P-value:3.36E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.72|P-value:4.71E-4

Top fitness defect scores for YDL192W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2567 aureobasidin a 30.00 60.0 nM 4.74E-158 1 7.93E-198
2 SGTC_1687 st020778 21.70 55.4 µM 1.39E-83 5 2.08E-104
3 SGTC_391 gliotoxin 18.40 8.3 µM 6.32E-61 2 5.51E-76
4 SGTC_1873 rapamycin 15.00 2.0 nM 3.84E-41 1 3.59E-51
5 SGTC_841 0251-0215 12.80 91.2 µM 1.07E-30 6 4.47E-38
6 SGTC_1495 4469-0029 11.80 237.0 µM 2.24E-26 8 1.17E-32
7 SGTC_528 3492-0019 11.40 172.0 µM 1.22E-24 calcium & mitochondrial duress 35 1.76E-30
8 SGTC_2737 bleomycin 11.40 30.5 nM 1.65E-24 Golgi 8 2.56E-30
9 SGTC_70 0141-0289 9.71 43.3 µM 2.38E-18 mitochondrial stress 21 1.34E-22
10 SGTC_1666 st014829 9.68 29.0 µM 3.16E-18 calcium & mitochondrial duress 4 1.92E-22
11 SGTC_2619 obliquin 8.76 87.9 µM 2.84E-15 cell wall 34 9.61E-19
12 SGTC_1874 staurosporine 8.69 7.6 µM 4.70E-15 cell wall signaling 5 1.81E-18
13 SGTC_124 0136-0217 8.44 7.1 µM 2.67E-14 mitochondrial stress 7 1.59E-17
14 SGTC_1244 0416-0015 8.39 52.5 µM 3.77E-14 ERG2 2 2.45E-17
15 SGTC_2200 6600604 8.08 21.9 µM 3.01E-13 tubulin folding & SWR complex 15 3.30E-16
16 SGTC_2249 haloperidol 7.37 116.4 µM 2.50E-11 ergosterol depletion effects on membrane 29 8.35E-14
17 SGTC_2077 5212015 7.34 200.0 µM 3.02E-11 16 1.06E-13
18 SGTC_488 nitrendipine 7.10 139.0 µM 1.27E-10 9 6.34E-13
19 SGTC_459 nigericin 7.00 15.3 µM 2.19E-10 20 1.26E-12
20 SGTC_197 4544-0043 6.86 41.6 µM 4.92E-10 endomembrane recycling 11 3.46E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.386 2.28E-119 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.378 2.31E-114 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.377 3.64E-113 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.362 1.52E-104 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.355 9.64E-100 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.350 4.52E-97 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.334 5.65E-88 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.333 9.32E-88 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.311 2.60E-76 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.305 4.54E-73 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.304 1.24E-72 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.304 1.27E-72 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.302 1.53E-71 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.298 1.09E-69 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.289 1.40E-65 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p