HIPHOP chemogenomics database

YDL198C / GGC1

Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL198C / GGC1

Click on Significant Values for Screen Details

Top fitness defect scores for YDL198C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_173	1273-0061	8.38	2.7 µM	9.65E-17	mitochondrial stress	59	2.64E-17
2	SGTC_236	1509-0011	8.05	5.3 µM	1.35E-15		249	4.06E-16
3	SGTC_156	3474-0145	7.94	5.6 µM	3.27E-15	endomembrane recycling	10	1.01E-15
4	SGTC_1635	st007035	6.90	42.4 µM	6.37E-12		119	2.58E-12
5	SGTC_310	1273-0058	6.63	1.1 µM	3.79E-11	mitochondrial stress	128	1.64E-11
6	SGTC_2570	licareol	6.32	100.0 µM	2.78E-10		4	1.29E-10
7	SGTC_275	trichlorophene	6.01	5.7 µM	1.85E-9	mitochondrial stress	118	9.20E-10
8	SGTC_159	3970-0959	5.97	50.0 µM	2.35E-9		26	1.18E-9
9	SGTC_2682	pyrogallin	5.06	40.0 µM	3.49E-7	copper-dependent oxidative stress	11	2.09E-7
10	SGTC_1521	st012942	4.93	49.4 µM	6.72E-7		13	4.12E-7
11	SGTC_2513	baicalein	4.89	25.6 µM	8.34E-7	calcium & mitochondrial duress	12	5.15E-7
12	SGTC_2250	alverine citrate	4.77	130.0 µM	1.49E-6		105	9.39E-7
13	SGTC_1188	1403-0014	4.71	4.6 µM	1.96E-6	mitochondrial stress	35	1.25E-6
14	SGTC_54	0159-0055	4.64	9.0 µM	2.67E-6	ERG2	33	1.72E-6
15	SGTC_2113	5491891	4.52	107.0 µM	4.64E-6	TSC3-RPN4	8	3.05E-6
16	SGTC_433	pimozide	4.38	108.0 µM	8.91E-6		12	5.99E-6
17	SGTC_1834	st055981	4.28	52.8 µM	1.39E-5	RPP1 & pyrimidine depletion	27	9.46E-6
18	SGTC_211	3455-0679	4.28	143.5 µM	1.40E-5		12	9.53E-6
19	SGTC_2844	9010103	4.18	26.0 µM	2.11E-5		28	1.46E-5
20	SGTC_1113	artemisinin	4.17	1.2 µM	2.21E-5	heme biosynthesis & mitochondrial translocase	11	1.53E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.453	6.01E-169	YLR369W	SSQ1	hom	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
0.403	6.29E-131	YGR257C	MTM1	hom	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.398	8.21E-128	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.389	1.15E-121	YBR179C	FZO1	hom	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.384	4.99E-118	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.366	1.19E-106	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.360	4.44E-103	YOR158W	PET123	hom	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.357	2.90E-101	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.357	4.29E-101	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.356	9.19E-101	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.356	1.54E-100	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.351	8.47E-98	YGR150C	CCM1	hom	Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.350	2.16E-97	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.343	2.84E-93	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.340	2.23E-91	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit