YDL199C_p

Putative transporter, member of the sugar porter family

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL199C / YDL199C

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.99|P-value:6.27E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.25|P-value:2.09E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.36|P-value:1.18E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.93|P-value:9.67E-6 ID:SGTC_484|Compound:loperamide|FD-Score:-2.93|P-value:7.39E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.18|P-value:2.73E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.20|P-value:2.31E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.15|P-value:3.20E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.49|P-value:6.85E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.62|P-value:3.68E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.18|P-value:2.47E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.33|P-value:1.49E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.23|P-value:2.02E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.94|P-value:6.44E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.99|P-value:5.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.74|P-value:1.14E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.42|P-value:1.89E-9 ID:SGTC_1581|Compound:himbacine|FD-Score:3.17|P-value:2.65E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.54|P-value:5.92E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.05|P-value:4.23E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.53|P-value:5.57E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.16|P-value:2.97E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.41|P-value:9.41E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.82|P-value:1.63E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.31|P-value:1.25E-6 ID:SGTC_1898|Compound:st060199|FD-Score:-3.04|P-value:4.92E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.15|P-value:3.19E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.85|P-value:1.46E-5 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.40|P-value:1.11E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-2.88|P-value:8.90E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.49|P-value:7.66E-5 ID:SGTC_2787|Compound:5284540|FD-Score:2.89|P-value:7.63E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.17|P-value:2.88E-4 ID:SGTC_2859|Compound:9028643|FD-Score:4.30|P-value:1.30E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-4.32|P-value:1.33E-6 ID:SGTC_2949|Compound:9072542|FD-Score:3.34|P-value:1.27E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.32|P-value:1.15E-6 ID:SGTC_2991|Compound:9074669|FD-Score:6.15|P-value:9.06E-12 ID:SGTC_3039|Compound:9090270|FD-Score:2.92|P-value:6.90E-4 ID:SGTC_3081|Compound:9117243|FD-Score:2.89|P-value:7.79E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.87|P-value:1.15E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.99|P-value:6.27E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.25|P-value:2.09E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.36|P-value:1.18E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.93|P-value:9.67E-6 ID:SGTC_484|Compound:loperamide|FD-Score:-2.93|P-value:7.39E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.18|P-value:2.73E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.20|P-value:2.31E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.15|P-value:3.20E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.49|P-value:6.85E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.62|P-value:3.68E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.18|P-value:2.47E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.33|P-value:1.49E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.23|P-value:2.02E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.94|P-value:6.44E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.99|P-value:5.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.74|P-value:1.14E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.42|P-value:1.89E-9 ID:SGTC_1581|Compound:himbacine|FD-Score:3.17|P-value:2.65E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.54|P-value:5.92E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.05|P-value:4.23E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.53|P-value:5.57E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.16|P-value:2.97E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.41|P-value:9.41E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.82|P-value:1.63E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.31|P-value:1.25E-6 ID:SGTC_1898|Compound:st060199|FD-Score:-3.04|P-value:4.92E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.15|P-value:3.19E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.85|P-value:1.46E-5 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.40|P-value:1.11E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-2.88|P-value:8.90E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.49|P-value:7.66E-5 ID:SGTC_2787|Compound:5284540|FD-Score:2.89|P-value:7.63E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.17|P-value:2.88E-4 ID:SGTC_2859|Compound:9028643|FD-Score:4.30|P-value:1.30E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-4.32|P-value:1.33E-6 ID:SGTC_2949|Compound:9072542|FD-Score:3.34|P-value:1.27E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.32|P-value:1.15E-6 ID:SGTC_2991|Compound:9074669|FD-Score:6.15|P-value:9.06E-12 ID:SGTC_3039|Compound:9090270|FD-Score:2.92|P-value:6.90E-4 ID:SGTC_3081|Compound:9117243|FD-Score:2.89|P-value:7.79E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.87|P-value:1.15E-5

Top fitness defect scores for YDL199C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2991 9074669 6.15 71.4 µM 9.06E-12 azole & statin 21 3.82E-10
2 SGTC_2989 9073649 4.32 71.4 µM 1.15E-6 26 7.76E-6
3 SGTC_1861 st057647 4.31 17.4 µM 1.25E-6 12 8.32E-6
4 SGTC_2859 9028643 4.30 45.5 µM 1.30E-6 10 8.62E-6
5 SGTC_38 0929-0051 3.99 58.3 µM 6.27E-6 16 3.25E-5
6 SGTC_3097 9117246 3.87 49.5 µM 1.15E-5 9 5.42E-5
7 SGTC_1139 k015-0024 3.62 46.9 µM 3.68E-5 PDR1 16 1.45E-4
8 SGTC_1700 st030840 3.53 7.9 µM 5.57E-5 PDR1 32 2.06E-4
9 SGTC_1088 bifonazole 3.49 369.0 nM 6.85E-5 28 2.46E-4
10 SGTC_1855 st056195 3.41 39.6 µM 9.41E-5 60S ribosome export 34 3.22E-4
11 SGTC_50 0929-0078 3.36 56.4 µM 1.18E-4 75 3.89E-4
12 SGTC_2949 9072542 3.34 2.2 µM 1.27E-4 TSC3-RPN4 65 4.16E-4
13 SGTC_1275 0867-0008 3.23 21.1 µM 2.02E-4 32 6.16E-4
14 SGTC_907 3448-6986 3.20 75.5 µM 2.31E-4 52 6.89E-4
15 SGTC_1142 3253-1408 3.18 9.8 µM 2.47E-4 27 7.28E-4
16 SGTC_1581 himbacine 3.17 57.9 µM 2.65E-4 Golgi 72 7.73E-4
17 SGTC_1676 st018489 3.05 23.4 µM 4.23E-4 60S ribosome export 74 0.00115
18 SGTC_1283 0922-0125 2.94 16.4 µM 6.44E-4 65 0.00164
19 SGTC_3039 9090270 2.92 49.5 µM 6.90E-4 RPP1 & pyrimidine depletion 42 0.00174
20 SGTC_2787 5284540 2.89 71.4 µM 7.63E-4 78 0.00190

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.288 5.26E-65 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.269 8.81E-57 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.269 1.45E-56 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.266 1.52E-55 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.262 6.41E-54 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.251 2.72E-49 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.251 3.66E-49 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.248 6.75E-48 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.237 3.82E-44 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.232 4.38E-42 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.232 3.90E-42 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.225 1.37E-39 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.214 4.84E-36 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.209 2.23E-34 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.207 1.21E-33 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress