YDL210W / UGA4

Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL210W / UGA4

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:-2.85|P-value:5.65E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.28|P-value:9.00E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.38|P-value:2.79E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:2.74|P-value:8.71E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.06|P-value:2.33E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.32|P-value:7.58E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:12.00|P-value:8.41E-43 ID:SGTC_439|Compound:amiodarone|FD-Score:2.93|P-value:4.18E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:2.71|P-value:9.69E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.56|P-value:2.40E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:2.92|P-value:4.20E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.08|P-value:2.18E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.84|P-value:5.90E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.43|P-value:4.58E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.42|P-value:4.63E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-2.95|P-value:3.79E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.97|P-value:3.38E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.78|P-value:7.50E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.20|P-value:1.27E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-2.86|P-value:5.33E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.83|P-value:6.14E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.21|P-value:1.20E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.04|P-value:2.58E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.77|P-value:8.27E-6 ID:SGTC_2193|Compound:5925765|FD-Score:-2.97|P-value:3.51E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.96|P-value:3.57E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:2.71|P-value:9.98E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-2.72|P-value:9.41E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.85|P-value:5.79E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-2.79|P-value:7.27E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.73|P-value:9.10E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-2.88|P-value:5.01E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.35|P-value:6.41E-5 ID:SGTC_3080|Compound:9117754|FD-Score:2.88|P-value:5.08E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.09|P-value:2.10E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-2.85|P-value:5.65E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.28|P-value:9.00E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.38|P-value:2.79E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:2.74|P-value:8.71E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.06|P-value:2.33E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.32|P-value:7.58E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:12.00|P-value:8.41E-43 ID:SGTC_439|Compound:amiodarone|FD-Score:2.93|P-value:4.18E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:2.71|P-value:9.69E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.56|P-value:2.40E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:2.92|P-value:4.20E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.08|P-value:2.18E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.84|P-value:5.90E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.43|P-value:4.58E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.42|P-value:4.63E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-2.95|P-value:3.79E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.97|P-value:3.38E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.78|P-value:7.50E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.20|P-value:1.27E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-2.86|P-value:5.33E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.83|P-value:6.14E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.21|P-value:1.20E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.04|P-value:2.58E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.77|P-value:8.27E-6 ID:SGTC_2193|Compound:5925765|FD-Score:-2.97|P-value:3.51E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.96|P-value:3.57E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:2.71|P-value:9.98E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-2.72|P-value:9.41E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.85|P-value:5.79E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-2.79|P-value:7.27E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.73|P-value:9.10E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-2.88|P-value:5.01E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.35|P-value:6.41E-5 ID:SGTC_3080|Compound:9117754|FD-Score:2.88|P-value:5.08E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.09|P-value:2.10E-4

Top fitness defect scores for YDL210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 12.00 8.0 µM 8.41E-43 2 2.79E-33
2 SGTC_2014 4013930 3.77 200.0 µM 8.27E-6 37 8.10E-5
3 SGTC_647 0140-0236 3.56 81.0 µM 2.40E-5 19 1.86E-4
4 SGTC_1282 0886-0010 3.43 32.4 µM 4.58E-5 endomembrane recycling 52 3.06E-4
5 SGTC_2978 9011784 3.35 43.0 µM 6.41E-5 55 3.98E-4
6 SGTC_96 0929-0093 3.28 37.3 µM 9.00E-5 calcium & mitochondrial duress 32 5.19E-4
7 SGTC_1903 st060211 3.04 78.3 µM 2.58E-4 77 0.00118
8 SGTC_2393 9031399 2.96 185.9 µM 3.57E-4 RNA processing & uracil transport 78 0.00152
9 SGTC_439 amiodarone 2.93 34.4 µM 4.18E-4 NEO1-PIK1 162 0.00172
10 SGTC_865 0488-0499 2.92 301.0 µM 4.20E-4 51 0.00172
11 SGTC_3080 9117754 2.88 49.5 µM 5.08E-4 62 0.00200
12 SGTC_2752 diclazuril 2.85 33.1 µM 5.79E-4 214 0.00222
13 SGTC_1098 clofazimine 2.84 15.1 µM 5.90E-4 heme biosynthesis & mitochondrial translocase 96 0.00225
14 SGTC_1563 conessine 2.78 56.1 µM 7.50E-4 81 0.00271
15 SGTC_315 k915-0449 2.74 187.0 µM 8.71E-4 136 0.00305
16 SGTC_509 pifithrin 2.71 175.0 µM 9.69E-4 mitochondrial processes 39 0.00332
17 SGTC_2736 butenafine 2.71 14.7 µM 9.98E-4 101 0.00339
18 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 2.71 100.0 µM 0.00101 85 0.00341
19 SGTC_2976 9009005 2.63 19.5 µM 0.00134 93 0.00427
20 SGTC_3264 9137442 2.59 49.5 µM 0.00157 64 0.00484

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.265 6.74E-55 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.243 2.84E-46 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.207 1.14E-33 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.190 1.07E-28 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.186 1.63E-27 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.176 1.12E-24 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.174 2.88E-24 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.155 1.60E-19 YOR299W BUD7 hom Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication
0.154 2.88E-19 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.153 5.66E-19 YDL027C_p YDL027C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
0.152 6.34E-19 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.151 1.86E-18 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.150 2.78E-18 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.143 7.39E-17 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.143 7.87E-17 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress