HIPHOP chemogenomics database
YDL215C / GDH2 
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDL215C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.116 | 1.47E-11 | YGR292W | MAL12 | hom | Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose |
| 0.109 | 2.20E-10 | YJR035W | RAD26 | hom | Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein |
| 0.107 | 4.73E-10 | YDR414C | ERD1 | hom | Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) |
| 0.106 | 6.53E-10 | YHR001W-A | QCR10 | hom | Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain |
| 0.104 | 1.51E-9 | YCL074W | YCL074W | hom | Pseudogene: encodes fragment of Ty Pol protein |
| 0.104 | 1.66E-9 | YLR063W_p | YLR063W_p | hom | Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene |
| 0.101 | 4.38E-9 | YOR109W | INP53 | hom | Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains |
| 0.098 | 1.38E-8 | YOR020W-A_p | YOR020W-A_p | hom | Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.097 | 1.80E-8 | YAR029W_p | YAR029W_p | hom | Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
| 0.095 | 3.52E-8 | YDR509W_d | YDR509W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.095 | 4.04E-8 | YGR044C | RME1 | hom | Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress |
| 0.094 | 5.61E-8 | YPL036W | PMA2 | hom | Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential |
| 0.092 | 8.34E-8 | YBR131W | CCZ1 | hom | Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway |
| 0.092 | 9.84E-8 | YPL236C | ENV7 | hom | Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) |
| 0.091 | 1.49E-7 | YNL257C | SIP3 | hom | Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication |