YDL222C / FMP45

Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL222C / FMP45

Click on Significant Values for Screen Details ID:SGTC_358|Compound:0075-0058|FD-Score:2.69|P-value:8.98E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.59|P-value:1.42E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.02|P-value:2.31E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.93|P-value:3.07E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.06|P-value:1.93E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.32|P-value:5.71E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.19|P-value:9.98E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:2.92|P-value:3.45E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.49|P-value:8.24E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.76|P-value:1.47E-8 ID:SGTC_1728|Compound:st035614|FD-Score:3.12|P-value:1.47E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.06|P-value:1.77E-4 ID:SGTC_1976|Compound:st070609|FD-Score:2.89|P-value:4.01E-4 ID:SGTC_2008|Compound:4012253|FD-Score:2.85|P-value:4.75E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.91|P-value:3.69E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.36|P-value:4.83E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.43|P-value:1.30E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.69|P-value:8.96E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.32|P-value:5.37E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.06|P-value:1.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.22|P-value:8.68E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.69|P-value:9.12E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-2.84|P-value:4.62E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:2.79|P-value:5.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.15|P-value:1.29E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.00|P-value:2.45E-4 ID:SGTC_2811|Compound:7967822|FD-Score:2.82|P-value:5.41E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.06|P-value:1.20E-6 ID:SGTC_2826|Compound:7992541|FD-Score:-2.88|P-value:3.80E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.94|P-value:3.25E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.06|P-value:1.89E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.06|P-value:1.88E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.80|P-value:5.39E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.79|P-value:5.90E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.69|P-value:8.98E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.59|P-value:1.42E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.02|P-value:2.31E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.93|P-value:3.07E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.06|P-value:1.93E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.32|P-value:5.71E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.19|P-value:9.98E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:2.92|P-value:3.45E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.49|P-value:8.24E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.76|P-value:1.47E-8 ID:SGTC_1728|Compound:st035614|FD-Score:3.12|P-value:1.47E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.06|P-value:1.77E-4 ID:SGTC_1976|Compound:st070609|FD-Score:2.89|P-value:4.01E-4 ID:SGTC_2008|Compound:4012253|FD-Score:2.85|P-value:4.75E-4 ID:SGTC_2022|Compound:5136654|FD-Score:2.91|P-value:3.69E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.36|P-value:4.83E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.43|P-value:1.30E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.69|P-value:8.96E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.32|P-value:5.37E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.06|P-value:1.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.22|P-value:8.68E-5 ID:SGTC_2354|Compound:9060492|FD-Score:2.69|P-value:9.12E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:-2.84|P-value:4.62E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:2.79|P-value:5.96E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.15|P-value:1.29E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.00|P-value:2.45E-4 ID:SGTC_2811|Compound:7967822|FD-Score:2.82|P-value:5.41E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.06|P-value:1.20E-6 ID:SGTC_2826|Compound:7992541|FD-Score:-2.88|P-value:3.80E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.94|P-value:3.25E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.06|P-value:1.89E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.06|P-value:1.88E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.80|P-value:5.39E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.79|P-value:5.90E-4

Top fitness defect scores for YDL222C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2125 5246583 4.43 200.0 µM 1.30E-7 tubulin folding & SWR complex 32 4.65E-6
2 SGTC_2821 7996764 4.06 71.4 µM 1.20E-6 31 2.46E-5
3 SGTC_2042 p-Dimethylaminoacetophenone 3.36 200.0 µM 4.83E-5 42 3.94E-4
4 SGTC_1211 1056-0033 3.32 32.3 µM 5.71E-5 22 4.46E-4
5 SGTC_2690 usnic acid 3.15 100.0 µM 1.29E-4 67 8.25E-4
6 SGTC_1728 st035614 3.12 33.8 µM 1.47E-4 102 9.11E-4
7 SGTC_2989 9073649 3.06 71.4 µM 1.88E-4 90 0.00110
8 SGTC_2846 9008642 3.06 19.5 µM 1.89E-4 41 0.00110
9 SGTC_2306 7482397 3.06 179.5 µM 1.92E-4 RPP1 & pyrimidine depletion 58 0.00111
10 SGTC_1111 tnp00062 3.06 510.7 nM 1.93E-4 30 0.00112
11 SGTC_381 3461-2219 3.02 42.7 µM 2.31E-4 copper-dependent oxidative stress 59 0.00128
12 SGTC_2691 st077356 3.00 60.2 µM 2.45E-4 77 0.00134
13 SGTC_2835 9006588 2.94 71.4 µM 3.25E-4 100 0.00166
14 SGTC_1345 1488-0192 2.92 31.4 µM 3.45E-4 60 0.00173
15 SGTC_2022 5136654 2.91 200.0 µM 3.69E-4 68 0.00182
16 SGTC_1976 st070609 2.89 63.5 µM 4.01E-4 47 0.00194
17 SGTC_2008 4012253 2.85 172.0 µM 4.75E-4 91 0.00220
18 SGTC_2811 7967822 2.82 32.5 µM 5.41E-4 77 0.00243
19 SGTC_3225 9130819 2.79 49.5 µM 5.90E-4 amide catabolism 74 0.00260
20 SGTC_2675 theaflavin digallate 2.79 100.0 µM 5.96E-4 iron homeostasis 94 0.00262

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.396 2.50E-126 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.348 4.41E-96 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.345 5.34E-94 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.322 5.39E-81 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.318 1.61E-79 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.295 3.07E-68 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.295 3.34E-68 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.294 8.96E-68 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.292 7.38E-67 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.291 2.68E-66 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.291 3.26E-66 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.282 3.27E-62 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.281 6.24E-62 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.281 6.72E-62 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.277 3.05E-60 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C