YDL224C / WHI4

Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL224C / WHI4

Click on Significant Values for Screen Details ID:SGTC_292|Compound:k038-0015|FD-Score:2.80|P-value:6.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.06|P-value:2.22E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.60|P-value:3.26E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.03|P-value:4.04E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:2.92|P-value:4.07E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.66|P-value:1.42E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.76|P-value:8.68E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.21|P-value:3.06E-9 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.64|P-value:1.15E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.70|P-value:1.95E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.01|P-value:4.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.21|P-value:1.40E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:4.65|P-value:5.94E-8 ID:SGTC_941|Compound:3237-0776|FD-Score:2.88|P-value:4.81E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.70|P-value:8.06E-8 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.91|P-value:4.23E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.10|P-value:2.95E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-2.83|P-value:8.93E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.34|P-value:6.54E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.77|P-value:8.39E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:5.27|P-value:9.89E-10 ID:SGTC_1739|Compound:st037196|FD-Score:3.33|P-value:6.80E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-3.78|P-value:1.31E-5 ID:SGTC_1839|Compound:st053978|FD-Score:-3.71|P-value:1.92E-5 ID:SGTC_1908|Compound:st060353|FD-Score:2.88|P-value:4.82E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.73|P-value:1.75E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.83|P-value:5.84E-4 ID:SGTC_2257|Compound:7960413|FD-Score:2.99|P-value:3.06E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.83|P-value:8.76E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.62|P-value:7.15E-8 ID:SGTC_2309|Compound:7664088|FD-Score:4.16|P-value:1.01E-6 ID:SGTC_2313|Compound:7726885|FD-Score:3.38|P-value:5.33E-5 ID:SGTC_2315|Compound:7733312|FD-Score:2.80|P-value:6.39E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.86|P-value:7.77E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.90|P-value:4.19E-6 ID:SGTC_2412|Compound:st077135|FD-Score:5.52|P-value:1.63E-10 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.19|P-value:8.62E-7 ID:SGTC_2811|Compound:7967822|FD-Score:-3.28|P-value:1.39E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.62|P-value:1.75E-5 ID:SGTC_3046|Compound:9092212|FD-Score:-2.85|P-value:7.98E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.84|P-value:1.01E-5 ID:SGTC_3321|Compound:9137793|FD-Score:-3.04|P-value:3.84E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:2.80|P-value:6.50E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.06|P-value:2.22E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.60|P-value:3.26E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.03|P-value:4.04E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:2.92|P-value:4.07E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.66|P-value:1.42E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.76|P-value:8.68E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.21|P-value:3.06E-9 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.64|P-value:1.15E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.70|P-value:1.95E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.01|P-value:4.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.21|P-value:1.40E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:4.65|P-value:5.94E-8 ID:SGTC_941|Compound:3237-0776|FD-Score:2.88|P-value:4.81E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.70|P-value:8.06E-8 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.91|P-value:4.23E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.10|P-value:2.95E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-2.83|P-value:8.93E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.34|P-value:6.54E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.77|P-value:8.39E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:5.27|P-value:9.89E-10 ID:SGTC_1739|Compound:st037196|FD-Score:3.33|P-value:6.80E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-3.78|P-value:1.31E-5 ID:SGTC_1839|Compound:st053978|FD-Score:-3.71|P-value:1.92E-5 ID:SGTC_1908|Compound:st060353|FD-Score:2.88|P-value:4.82E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.73|P-value:1.75E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.83|P-value:5.84E-4 ID:SGTC_2257|Compound:7960413|FD-Score:2.99|P-value:3.06E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.83|P-value:8.76E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.62|P-value:7.15E-8 ID:SGTC_2309|Compound:7664088|FD-Score:4.16|P-value:1.01E-6 ID:SGTC_2313|Compound:7726885|FD-Score:3.38|P-value:5.33E-5 ID:SGTC_2315|Compound:7733312|FD-Score:2.80|P-value:6.39E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.86|P-value:7.77E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.90|P-value:4.19E-6 ID:SGTC_2412|Compound:st077135|FD-Score:5.52|P-value:1.63E-10 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.19|P-value:8.62E-7 ID:SGTC_2811|Compound:7967822|FD-Score:-3.28|P-value:1.39E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.62|P-value:1.75E-5 ID:SGTC_3046|Compound:9092212|FD-Score:-2.85|P-value:7.98E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.84|P-value:1.01E-5 ID:SGTC_3321|Compound:9137793|FD-Score:-3.04|P-value:3.84E-4

Top fitness defect scores for YDL224C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2412 st077135 5.52 33.4 µM 1.63E-10 4 1.65E-8
2 SGTC_1718 roemerine 5.27 11.9 µM 9.89E-10 redox potentiating 19 6.81E-8
3 SGTC_835 0312-0010 4.65 67.2 µM 5.94E-8 6 1.70E-6
4 SGTC_2297 7971671 4.62 152.3 µM 7.15E-8 RNA processing & uracil transport 12 1.96E-6
5 SGTC_2799 7812892 4.19 81.8 µM 8.62E-7 superoxide 26 1.39E-5
6 SGTC_2309 7664088 4.16 163.9 µM 1.01E-6 19 1.57E-5
7 SGTC_2410 aloe-emodin-8-o-glycoside 3.90 46.3 µM 4.19E-6 mitochondrial processes 33 4.81E-5
8 SGTC_1611 st001856 3.77 99.4 µM 8.39E-6 21 8.30E-5
9 SGTC_608 k048-0125 3.76 159.0 µM 8.68E-6 37 8.53E-5
10 SGTC_549 1661-1316 3.66 519.0 µM 1.42E-5 23 1.26E-4
11 SGTC_2814 7977482 3.62 43.0 µM 1.75E-5 63 1.48E-4
12 SGTC_2313 7726885 3.38 200.0 µM 5.33E-5 RPP1 & pyrimidine depletion 55 3.56E-4
13 SGTC_1521 st012942 3.34 49.4 µM 6.54E-5 58 4.18E-4
14 SGTC_1739 st037196 3.33 92.5 µM 6.80E-5 45 4.31E-4
15 SGTC_299 1273-0059 3.06 1.4 µM 2.22E-4 54 0.00109
16 SGTC_2257 7960413 2.99 200.0 µM 3.06E-4 NEO1-PIK1 118 0.00141
17 SGTC_532 1548-0774 2.92 215.0 µM 4.07E-4 60 0.00177
18 SGTC_1261 0712-0010 2.91 12.7 µM 4.23E-4 RNA processing & uracil transport 78 0.00182
19 SGTC_941 3237-0776 2.88 460.0 µM 4.81E-4 67 0.00201
20 SGTC_1908 st060353 2.88 56.5 µM 4.82E-4 RPP1 & pyrimidine depletion 93 0.00202

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.272 7.30E-58 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.267 8.57E-56 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.232 2.40E-42 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.229 4.61E-41 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.229 5.84E-41 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.197 1.18E-30 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.194 7.89E-30 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.181 3.86E-26 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.179 1.05E-25 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.178 3.28E-25 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.176 1.17E-24 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.172 1.03E-23 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.171 1.63E-23 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.165 7.37E-22 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.165 7.91E-22 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data