HIPHOP chemogenomics database

YDL234C / GYP7

GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL234C / GYP7

Click on Significant Values for Screen Details

Top fitness defect scores for YDL234C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3309	9129340	6.73	25.8 µM	4.59E-15		3	8.39E-12
2	SGTC_234	nsc-17383	4.15	10.7 µM	8.66E-7	ERG2	21	1.64E-5
3	SGTC_996	3970-0799	3.62	1.8 µM	1.54E-5		101	1.48E-4
4	SGTC_2398	5228213	3.53	48.8 µM	2.42E-5	iron homeostasis	53	2.10E-4
5	SGTC_2021	4019055	3.43	173.0 µM	3.86E-5	endomembrane recycling	168	3.00E-4
6	SGTC_2014	4013930	3.42	200.0 µM	4.14E-5		63	3.16E-4
7	SGTC_1004	4084-0029	3.33	199.0 µM	6.13E-5		39	4.27E-4
8	SGTC_1043	0916-0009	3.16	19.3 µM	1.37E-4		57	7.90E-4
9	SGTC_3300	9124615	3.15	50.5 µM	1.41E-4		52	8.08E-4
10	SGTC_1988	st071872	3.14	53.4 µM	1.48E-4		33	8.38E-4
11	SGTC_1365	1672-3266	3.05	55.4 µM	2.25E-4		59	0.00116
12	SGTC_244	nsc-207895	3.01	1.3 µM	2.63E-4	DNA damage response	32	0.00131
13	SGTC_2805	7950783	2.98	58.4 µM	3.01E-4		72	0.00145
14	SGTC_2086	5274770	2.94	176.6 µM	3.52E-4		78	0.00163
15	SGTC_653	0203-0016	2.92	55.2 µM	3.78E-4		62	0.00173
16	SGTC_1998	st075797	2.83	76.8 µM	5.60E-4	mitochondrial response to ROS	66	0.00234
17	SGTC_745	0469-0705	2.82	296.0 µM	5.80E-4	mitochondrial processes	81	0.00240
18	SGTC_1183	1254-0324	2.79	198.0 µM	6.50E-4		74	0.00262
19	SGTC_732	3970-1727	2.75	52.7 µM	7.69E-4		49	0.00298
20	SGTC_1255	0566-0045	2.72	221.0 µM	8.69E-4	excess fatty acid	113	0.00328

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.223	5.29E-39	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.216	7.22E-37	YFL014W	HSP12	hom	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.205	3.48E-33	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.201	5.76E-32	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.197	1.50E-30	YMR107W	SPG4	hom	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.194	8.30E-30	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.191	5.54E-29	YOR152C_p	YOR152C_p	hom	Putative protein of unknown function; YOR152C is not an essential gene
0.190	2.46E-28	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.187	1.05E-27	YDR530C	APA2	hom	Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.186	2.27E-27	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.185	2.89E-27	YOR267C	HRK1	hom	Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.175	1.70E-24	YDL099W	BUG1	hom	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.174	2.33E-24	YJR146W_p	YJR146W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.174	4.16E-24	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.172	8.46E-24	YMR322C_p	SNO4_p	hom	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation