YDL234C / GYP7

GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL234C / GYP7

Click on Significant Values for Screen Details ID:SGTC_234|Compound:nsc-17383|FD-Score:4.15|P-value:8.66E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.01|P-value:2.63E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-2.97|P-value:3.22E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-2.94|P-value:3.62E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.74|P-value:8.09E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:2.92|P-value:3.78E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.69|P-value:9.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.08|P-value:2.00E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.75|P-value:7.69E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:2.82|P-value:5.80E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.74|P-value:8.22E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.62|P-value:1.54E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.33|P-value:6.13E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.16|P-value:1.37E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:2.79|P-value:6.50E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.72|P-value:8.69E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.05|P-value:2.25E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.69|P-value:1.07E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.01|P-value:2.05E-6 ID:SGTC_1518|Compound:st038567|FD-Score:-2.93|P-value:3.76E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.69|P-value:9.72E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.95|P-value:2.85E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.51|P-value:2.71E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.14|P-value:1.48E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.83|P-value:5.60E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.42|P-value:4.14E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.43|P-value:3.86E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-2.74|P-value:8.10E-4 ID:SGTC_2086|Compound:5274770|FD-Score:2.94|P-value:3.52E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-5.00|P-value:4.45E-9 ID:SGTC_2398|Compound:5228213|FD-Score:3.53|P-value:2.42E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-4.36|P-value:2.70E-7 ID:SGTC_2403|Compound:6032726|FD-Score:-4.79|P-value:1.86E-8 ID:SGTC_2486|Compound:5283202|FD-Score:-3.20|P-value:1.19E-4 ID:SGTC_2693|Compound:st077581|FD-Score:2.70|P-value:9.28E-4 ID:SGTC_2805|Compound:7950783|FD-Score:2.98|P-value:3.01E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.87|P-value:4.77E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.57|P-value:2.07E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.34|P-value:6.11E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.15|P-value:1.41E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.35|P-value:2.88E-7 ID:SGTC_3304|Compound:9125678|FD-Score:-3.08|P-value:1.98E-4 ID:SGTC_3309|Compound:9129340|FD-Score:6.73|P-value:4.59E-15 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.15|P-value:8.66E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.01|P-value:2.63E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-2.97|P-value:3.22E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-2.94|P-value:3.62E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.74|P-value:8.09E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:2.92|P-value:3.78E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.69|P-value:9.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.08|P-value:2.00E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.75|P-value:7.69E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:2.82|P-value:5.80E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.74|P-value:8.22E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.62|P-value:1.54E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.33|P-value:6.13E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.16|P-value:1.37E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:2.79|P-value:6.50E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.72|P-value:8.69E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.05|P-value:2.25E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.69|P-value:1.07E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.01|P-value:2.05E-6 ID:SGTC_1518|Compound:st038567|FD-Score:-2.93|P-value:3.76E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.69|P-value:9.72E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.95|P-value:2.85E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.51|P-value:2.71E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.14|P-value:1.48E-4 ID:SGTC_1998|Compound:st075797|FD-Score:2.83|P-value:5.60E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.42|P-value:4.14E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.43|P-value:3.86E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-2.74|P-value:8.10E-4 ID:SGTC_2086|Compound:5274770|FD-Score:2.94|P-value:3.52E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-5.00|P-value:4.45E-9 ID:SGTC_2398|Compound:5228213|FD-Score:3.53|P-value:2.42E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-4.36|P-value:2.70E-7 ID:SGTC_2403|Compound:6032726|FD-Score:-4.79|P-value:1.86E-8 ID:SGTC_2486|Compound:5283202|FD-Score:-3.20|P-value:1.19E-4 ID:SGTC_2693|Compound:st077581|FD-Score:2.70|P-value:9.28E-4 ID:SGTC_2805|Compound:7950783|FD-Score:2.98|P-value:3.01E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.87|P-value:4.77E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.57|P-value:2.07E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.34|P-value:6.11E-5 ID:SGTC_3300|Compound:9124615|FD-Score:3.15|P-value:1.41E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.35|P-value:2.88E-7 ID:SGTC_3304|Compound:9125678|FD-Score:-3.08|P-value:1.98E-4 ID:SGTC_3309|Compound:9129340|FD-Score:6.73|P-value:4.59E-15

Top fitness defect scores for YDL234C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3309 9129340 6.73 25.8 µM 4.59E-15 3 8.39E-12
2 SGTC_234 nsc-17383 4.15 10.7 µM 8.66E-7 ERG2 21 1.64E-5
3 SGTC_996 3970-0799 3.62 1.8 µM 1.54E-5 101 1.48E-4
4 SGTC_2398 5228213 3.53 48.8 µM 2.42E-5 iron homeostasis 53 2.10E-4
5 SGTC_2021 4019055 3.43 173.0 µM 3.86E-5 endomembrane recycling 168 3.00E-4
6 SGTC_2014 4013930 3.42 200.0 µM 4.14E-5 63 3.16E-4
7 SGTC_1004 4084-0029 3.33 199.0 µM 6.13E-5 39 4.27E-4
8 SGTC_1043 0916-0009 3.16 19.3 µM 1.37E-4 57 7.90E-4
9 SGTC_3300 9124615 3.15 50.5 µM 1.41E-4 52 8.08E-4
10 SGTC_1988 st071872 3.14 53.4 µM 1.48E-4 33 8.38E-4
11 SGTC_1365 1672-3266 3.05 55.4 µM 2.25E-4 59 0.00116
12 SGTC_244 nsc-207895 3.01 1.3 µM 2.63E-4 DNA damage response 32 0.00131
13 SGTC_2805 7950783 2.98 58.4 µM 3.01E-4 72 0.00145
14 SGTC_2086 5274770 2.94 176.6 µM 3.52E-4 78 0.00163
15 SGTC_653 0203-0016 2.92 55.2 µM 3.78E-4 62 0.00173
16 SGTC_1998 st075797 2.83 76.8 µM 5.60E-4 mitochondrial response to ROS 66 0.00234
17 SGTC_745 0469-0705 2.82 296.0 µM 5.80E-4 mitochondrial processes 81 0.00240
18 SGTC_1183 1254-0324 2.79 198.0 µM 6.50E-4 74 0.00262
19 SGTC_732 3970-1727 2.75 52.7 µM 7.69E-4 49 0.00298
20 SGTC_1255 0566-0045 2.72 221.0 µM 8.69E-4 excess fatty acid 113 0.00328

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 5.29E-39 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.216 7.22E-37 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.205 3.48E-33 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.201 5.76E-32 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.197 1.50E-30 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.194 8.30E-30 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.191 5.54E-29 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.190 2.46E-28 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.187 1.05E-27 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.186 2.27E-27 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.185 2.89E-27 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.175 1.70E-24 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.174 2.33E-24 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.174 4.16E-24 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.172 8.46E-24 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation