YDL236W / PHO13

Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL236W / PHO13

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.37|P-value:6.32E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.95|P-value:7.76E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.56|P-value:3.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.11|P-value:4.97E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.39|P-value:5.87E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.55|P-value:3.38E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.65|P-value:2.35E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.27|P-value:8.70E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.81|P-value:2.10E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.60|P-value:2.85E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.46|P-value:9.79E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.45|P-value:4.87E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.85|P-value:1.16E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.70|P-value:3.41E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-5.70|P-value:2.44E-8 ID:SGTC_2624|Compound:nerol|FD-Score:-4.69|P-value:3.66E-6 ID:SGTC_2625|Compound:euphol|FD-Score:3.26|P-value:8.92E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:8.91|P-value:7.33E-18 ID:SGTC_2784|Compound:7567673|FD-Score:4.72|P-value:3.08E-6 ID:SGTC_2796|Compound:7949634|FD-Score:4.11|P-value:4.14E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.74|P-value:1.73E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.87|P-value:1.07E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.17|P-value:3.27E-5 ID:SGTC_2889|Compound:9059656|FD-Score:-3.57|P-value:3.21E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.87|P-value:1.07E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.37|P-value:6.32E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.95|P-value:7.76E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.56|P-value:3.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.11|P-value:4.97E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.39|P-value:5.87E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.55|P-value:3.38E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.65|P-value:2.35E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.27|P-value:8.70E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.81|P-value:2.10E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.60|P-value:2.85E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.46|P-value:9.79E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.45|P-value:4.87E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.85|P-value:1.16E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.70|P-value:3.41E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-5.70|P-value:2.44E-8 ID:SGTC_2624|Compound:nerol|FD-Score:-4.69|P-value:3.66E-6 ID:SGTC_2625|Compound:euphol|FD-Score:3.26|P-value:8.92E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:8.91|P-value:7.33E-18 ID:SGTC_2784|Compound:7567673|FD-Score:4.72|P-value:3.08E-6 ID:SGTC_2796|Compound:7949634|FD-Score:4.11|P-value:4.14E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.74|P-value:1.73E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.87|P-value:1.07E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.17|P-value:3.27E-5 ID:SGTC_2889|Compound:9059656|FD-Score:-3.57|P-value:3.21E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.87|P-value:1.07E-4

Top fitness defect scores for YDL236W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2754 granisetron 8.91 64.0 µM 7.33E-18 1 2.49E-19
2 SGTC_453 enantio-paf c16 5.11 10.0 µM 4.97E-7 83 1.59E-7
3 SGTC_1654 st012436 4.81 41.8 µM 2.10E-6 8 7.61E-7
4 SGTC_2784 7567673 4.72 72.7 µM 3.08E-6 iron homeostasis 18 1.16E-6
5 SGTC_2598 perillyl alcohol 4.70 100.0 µM 3.41E-6 14 1.29E-6
6 SGTC_1744 st037937 4.46 38.9 µM 9.79E-6 15 4.07E-6
7 SGTC_2858 9025781 4.17 9.0 µM 3.27E-5 sphingolipid biosynthesis & PDR1 89 1.51E-5
8 SGTC_2796 7949634 4.11 45.5 µM 4.14E-5 17 1.95E-5
9 SGTC_3308 9128332 3.87 17.6 µM 1.07E-4 plasma membrane duress 80 5.49E-5
10 SGTC_1004 4084-0029 3.65 199.0 µM 2.35E-4 24 1.29E-4
11 SGTC_1665 st014639 3.60 11.4 µM 2.85E-4 NEO1 29 1.59E-4
12 SGTC_2021 4019055 3.45 173.0 µM 4.87E-4 endomembrane recycling 166 2.84E-4
13 SGTC_8 0354-0001 3.37 70.0 µM 6.32E-4 113 3.77E-4
14 SGTC_1219 1469-0211 3.27 33.1 µM 8.70E-4 33 5.34E-4
15 SGTC_2625 euphol 3.26 100.0 µM 8.92E-4 62 5.49E-4
16 SGTC_2602 kawain 3.23 100.0 µM 0.00101 60 6.27E-4
17 SGTC_2125 5246583 3.20 200.0 µM 0.00111 tubulin folding & SWR complex 86 6.98E-4
18 SGTC_779 1360-0071 3.16 233.0 µM 0.00126 fatty acid desaturase (OLE1) 68 7.96E-4
19 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.12 49.5 µM 0.00141 56 8.99E-4
20 SGTC_2781 5567276 3.09 71.4 µM 0.00157 110 0.00102

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.13E-17 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.139 7.32E-16 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.137 1.75E-15 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.137 2.23E-15 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.120 2.60E-12 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
0.120 3.19E-12 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.119 4.39E-12 YHL001W RPL14B hom Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.116 1.53E-11 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.111 1.37E-10 YJR100C AIM25 hom Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.109 2.78E-10 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.105 1.13E-9 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.104 1.52E-9 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.101 4.27E-9 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.100 6.06E-9 YGR141W VPS62 hom Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
0.098 1.33E-8 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions