YDR018C_p

Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR018C / YDR018C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.02|P-value:1.75E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.33|P-value:3.05E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.09|P-value:7.43E-4 ID:SGTC_446|Compound:go6976|FD-Score:-4.72|P-value:6.33E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:-6.14|P-value:1.43E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.36|P-value:2.76E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.02|P-value:1.77E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.03|P-value:1.76E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.20|P-value:4.95E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.30|P-value:3.44E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-4.10|P-value:1.25E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.98|P-value:1.54E-7 ID:SGTC_719|Compound:2810-4230|FD-Score:3.27|P-value:3.85E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.06|P-value:1.48E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.37|P-value:2.69E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.35|P-value:2.82E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.20|P-value:5.01E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.91|P-value:2.20E-7 ID:SGTC_1689|Compound:st020265|FD-Score:4.31|P-value:4.63E-6 ID:SGTC_1694|Compound:st024011|FD-Score:-3.03|P-value:9.38E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.11|P-value:6.81E-4 ID:SGTC_2204|Compound:7233102|FD-Score:-3.14|P-value:6.27E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.72|P-value:6.49E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.51|P-value:1.55E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.32|P-value:2.18E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.38|P-value:2.52E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.40|P-value:2.43E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.02|P-value:1.75E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.33|P-value:3.05E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.09|P-value:7.43E-4 ID:SGTC_446|Compound:go6976|FD-Score:-4.72|P-value:6.33E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:-6.14|P-value:1.43E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.36|P-value:2.76E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.02|P-value:1.77E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.03|P-value:1.76E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.20|P-value:4.95E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.30|P-value:3.44E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-4.10|P-value:1.25E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.98|P-value:1.54E-7 ID:SGTC_719|Compound:2810-4230|FD-Score:3.27|P-value:3.85E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.06|P-value:1.48E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.37|P-value:2.69E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.35|P-value:2.82E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.20|P-value:5.01E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.91|P-value:2.20E-7 ID:SGTC_1689|Compound:st020265|FD-Score:4.31|P-value:4.63E-6 ID:SGTC_1694|Compound:st024011|FD-Score:-3.03|P-value:9.38E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.11|P-value:6.81E-4 ID:SGTC_2204|Compound:7233102|FD-Score:-3.14|P-value:6.27E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.72|P-value:6.49E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.51|P-value:1.55E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.32|P-value:2.18E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.38|P-value:2.52E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.40|P-value:2.43E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.57|P-value:1.20E-4

Top fitness defect scores for YDR018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 5.32 8.5 µM 2.18E-8 18 5.05E-8
2 SGTC_660 4031-1742 4.98 102.0 µM 1.54E-7 redox potentiating 22 3.22E-7
3 SGTC_1673 st016611 4.91 27.3 µM 2.20E-7 23 4.51E-7
4 SGTC_1689 st020265 4.31 53.5 µM 4.63E-6 15 8.10E-6
5 SGTC_795 0685-0265 4.06 78.0 µM 1.48E-5 excess fatty acid 20 2.44E-5
6 SGTC_6 0844-0013 4.02 19.8 µM 1.75E-5 81 2.86E-5
7 SGTC_504 lovastatin 4.02 124.0 µM 1.77E-5 13 2.90E-5
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.72 3.7 µM 6.49E-5 103 9.91E-5
9 SGTC_3350 9150499 3.57 3.6 µM 1.20E-4 cell wall 70 1.77E-4
10 SGTC_455 paf C-16 3.57 10.0 µM 1.20E-4 41 1.78E-4
11 SGTC_2564 betulinic acid 3.38 100.0 µM 2.52E-4 54 3.59E-4
12 SGTC_457 grayanotoxin iii 3.36 135.0 µM 2.76E-4 111 3.92E-4
13 SGTC_1023 4482-3888 3.35 16.0 µM 2.82E-4 TSC3-RPN4 39 4.00E-4
14 SGTC_75 0159-0059 3.33 199.0 µM 3.05E-4 fatty acid desaturase (OLE1) 40 4.30E-4
15 SGTC_719 2810-4230 3.27 27.3 µM 3.85E-4 11 5.38E-4
16 SGTC_636 0kpi-0074 3.20 126.0 µM 4.95E-4 39 6.83E-4
17 SGTC_1127 asiatic acid 3.20 681.4 nM 5.01E-4 52 6.91E-4
18 SGTC_2105 5350118 3.11 200.0 µM 6.81E-4 61 9.24E-4
19 SGTC_107 0358-0022 3.09 2.7 µM 7.43E-4 SWF1 & branched chain AA biosynthesis 46 0.00100
20 SGTC_2889 9059656 2.97 52.0 µM 0.00114 36 0.00151

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 8.14E-18 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.137 1.77E-15 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.134 7.98E-15 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.132 1.74E-14 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.125 3.78E-13 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.125 3.99E-13 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.122 1.44E-12 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.120 3.09E-12 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.119 4.74E-12 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.118 6.68E-12 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.118 8.08E-12 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.117 9.52E-12 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.112 8.44E-11 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.110 1.65E-10 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.109 2.13E-10 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance