HIPHOP chemogenomics database

YDR028C / REG1

Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR028C / REG1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR028C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1884	5633444	15.70	25.0 µM	2.17E-28	redox potentiating	5	5.99E-56
2	SGTC_2858	9025781	15.30	9.0 µM	7.03E-27	sphingolipid biosynthesis & PDR1	11	6.84E-53
3	SGTC_1556	plumbagin	14.60	1.5 µM	1.07E-24	superoxide	3	1.77E-48
4	SGTC_781	4335-2806	13.00	94.4 µM	6.35E-20		1	8.08E-39
5	SGTC_1552	6-methylflavone	11.60	10.6 µM	3.82E-16	superoxide	2	3.55E-31
6	SGTC_1760	st045453	11.00	10.4 µM	8.76E-15	NEO1-PIK1	27	1.99E-28
7	SGTC_2752	diclazuril	10.90	33.1 µM	1.55E-14		20	6.34E-28
8	SGTC_221	trifluoperazine	10.80	10.3 µM	2.63E-14	NEO1-PIK1	47	1.84E-27
9	SGTC_2485	5633444	10.80	17.8 µM	2.86E-14	redox potentiating	3	2.18E-27
10	SGTC_1083	didemethylchlorpromazine sulfoxide	10.10	707.4 nM	1.13E-12	redox potentiating	5	3.66E-24
11	SGTC_470	aa-861	10.00	153.0 µM	1.65E-12	sphingolipid biosynthesis & PDR1	10	7.82E-24
12	SGTC_1803	st050068	9.99	52.4 µM	1.68E-12	NEO1-PIK1	25	8.12E-24
13	SGTC_1687	st020778	9.80	55.4 µM	4.35E-12		52	5.56E-23
14	SGTC_1941	st076221	9.67	61.8 µM	8.42E-12	sphingolipid biosynthesis & PDR1	14	2.11E-22
15	SGTC_2833	9001315	9.53	45.5 µM	1.59E-11	amide catabolism	3	7.59E-22
16	SGTC_3098	9119039	9.41	49.5 µM	2.81E-11	Golgi	1	2.41E-21
17	SGTC_2662	daunorubicin	9.35	22.4 µM	3.86E-11	anthracycline transcription coupled DNA repair	2	4.57E-21
18	SGTC_2322	7413319	9.22	38.2 µM	7.05E-11	ERAD & cell cycle	25	1.54E-20
19	SGTC_1801	st050089	9.04	28.4 µM	1.56E-10	NEO1-PIK1	18	7.67E-20
20	SGTC_3078	9116413	8.89	49.5 µM	3.04E-10	unfolded protein response	5	2.93E-19

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.279	4.59E-61	YDR392W	SPT3	hom	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.252	6.04E-50	YCL008C	STP22	hom	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.252	1.24E-49	YGR164W_d	YGR164W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.251	2.22E-49	YJR102C	VPS25	hom	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.245	3.31E-47	YPL065W	VPS28	hom	Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.237	4.98E-44	YBR246W	RRT2	hom	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.236	8.86E-44	YLR087C	CSF1	hom	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.229	4.15E-41	YPL002C	SNF8	hom	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.228	9.00E-41	YJL124C	LSM1	hom	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.228	1.15E-40	YLR417W	VPS36	hom	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.224	2.52E-39	YHR012W	VPS29	hom	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.221	2.21E-38	YLR025W	SNF7	hom	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.220	4.99E-38	YLR055C	SPT8	hom	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.218	2.79E-37	YNL267W	PIK1	het	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.215	2.44E-36	YDR159W	SAC3	hom	Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)