YDR030C / RAD28

Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR030C / RAD28

Click on Significant Values for Screen Details ID:SGTC_271|Compound:rotenone|FD-Score:4.33|P-value:6.84E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.79|P-value:6.68E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:3.92|P-value:4.08E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:5.13|P-value:1.27E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:4.02|P-value:2.68E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:4.04|P-value:2.39E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.04|P-value:2.41E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.29|P-value:4.75E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.38|P-value:3.22E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.77|P-value:7.05E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.28|P-value:4.85E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.17|P-value:6.92E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.66|P-value:1.15E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.33|P-value:4.09E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.94|P-value:3.70E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.85|P-value:5.44E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.96|P-value:3.18E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.24|P-value:5.68E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.75|P-value:8.25E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.16|P-value:7.54E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.87|P-value:5.10E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.31|P-value:7.40E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.17|P-value:7.19E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.26|P-value:5.24E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.82|P-value:5.75E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.23|P-value:5.66E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.76|P-value:8.16E-7 ID:SGTC_2348|Compound:9022543|FD-Score:3.13|P-value:8.24E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-4.49|P-value:2.95E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.78|P-value:6.82E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.64|P-value:1.28E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.57|P-value:1.69E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.14|P-value:8.08E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.73|P-value:8.84E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.37|P-value:3.59E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.09|P-value:9.24E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.30|P-value:4.62E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.41|P-value:3.08E-4 ID:SGTC_3248|Compound:9135562|FD-Score:4.66|P-value:1.38E-6 ID:SGTC_271|Compound:rotenone|FD-Score:4.33|P-value:6.84E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.79|P-value:6.68E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:3.92|P-value:4.08E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:5.13|P-value:1.27E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:4.02|P-value:2.68E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:4.04|P-value:2.39E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.04|P-value:2.41E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.29|P-value:4.75E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.38|P-value:3.22E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.77|P-value:7.05E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.28|P-value:4.85E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.17|P-value:6.92E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.66|P-value:1.15E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.33|P-value:4.09E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.94|P-value:3.70E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.85|P-value:5.44E-5 ID:SGTC_1677|Compound:st019204|FD-Score:-3.96|P-value:3.18E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.24|P-value:5.68E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.75|P-value:8.25E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.16|P-value:7.54E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.87|P-value:5.10E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.31|P-value:7.40E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.17|P-value:7.19E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.26|P-value:5.24E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.82|P-value:5.75E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.23|P-value:5.66E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.76|P-value:8.16E-7 ID:SGTC_2348|Compound:9022543|FD-Score:3.13|P-value:8.24E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-4.49|P-value:2.95E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.78|P-value:6.82E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.64|P-value:1.28E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.57|P-value:1.69E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.14|P-value:8.08E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.73|P-value:8.84E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.37|P-value:3.59E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.09|P-value:9.24E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.30|P-value:4.62E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.41|P-value:3.08E-4 ID:SGTC_3248|Compound:9135562|FD-Score:4.66|P-value:1.38E-6

Top fitness defect scores for YDR030C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_532 1548-0774 5.13 215.0 µM 1.27E-7 6 1.47E-7
2 SGTC_3248 9135562 4.66 49.5 µM 1.38E-6 3 1.56E-6
3 SGTC_271 rotenone 4.33 740.0 µM 6.84E-6 16 7.60E-6
4 SGTC_2008 4012253 4.31 172.0 µM 7.40E-6 17 8.21E-6
5 SGTC_671 0560-0003 4.04 407.0 µM 2.39E-5 10 2.62E-5
6 SGTC_676 falcarinol 4.04 140.0 µM 2.41E-5 52 2.64E-5
7 SGTC_639 0833-0042 4.02 114.0 µM 2.68E-5 42 2.93E-5
8 SGTC_1456 k015-0012 3.94 13.0 µM 3.70E-5 32 4.03E-5
9 SGTC_426 0988-0037 3.92 14.6 µM 4.08E-5 ERAD & cell cycle 33 4.44E-5
10 SGTC_2002 4023503 3.87 131.0 µM 5.10E-5 mitochondrial processes 33 5.54E-5
11 SGTC_1674 st016616 3.85 23.6 µM 5.44E-5 31 5.90E-5
12 SGTC_1739 st037196 3.75 92.5 µM 8.25E-5 30 8.91E-5
13 SGTC_2913 7966556 3.73 36.6 µM 8.84E-5 60S ribosome export 18 9.54E-5
14 SGTC_1341 1486-1360 3.66 280.0 µM 1.15E-4 35 1.24E-4
15 SGTC_2538 3',7'-epoxycaryophyllan-6-one 3.64 100.0 µM 1.28E-4 33 1.38E-4
16 SGTC_2613 3',4'-dimethoxydalbergione 3.57 24.6 µM 1.69E-4 39 1.81E-4
17 SGTC_3202 9113761 3.41 49.5 µM 3.08E-4 70 3.28E-4
18 SGTC_2947 9072639 3.37 7.7 µM 3.59E-4 tubulin folding & SWR complex 72 3.82E-4
19 SGTC_1347 1493-0251 3.33 600.0 nM 4.09E-4 mitochondrial response to ROS 35 4.33E-4
20 SGTC_2998 9066762 3.30 71.4 µM 4.62E-4 RPP1 & pyrimidine depletion 50 4.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.38E-12 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.108 3.06E-10 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.101 5.37E-9 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.098 1.47E-8 YFL017C GNA1 het Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
0.096 2.40E-8 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.092 8.83E-8 YOR054C VHS3 hom Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.088 3.28E-7 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.086 5.97E-7 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.086 6.15E-7 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.084 1.02E-6 YGR142W BTN2 hom v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
0.083 1.36E-6 YMR215W GAS3 hom Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.081 2.52E-6 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.081 2.49E-6 YLL024C SSA2 hom ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.078 5.40E-6 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.077 7.51E-6 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol