HIPHOP chemogenomics database

YDR030C / RAD28

Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR030C / RAD28

Click on Significant Values for Screen Details

Top fitness defect scores for YDR030C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_532	1548-0774	5.13	215.0 µM	1.27E-7		6	1.47E-7
2	SGTC_3248	9135562	4.66	49.5 µM	1.38E-6		3	1.56E-6
3	SGTC_271	rotenone	4.33	740.0 µM	6.84E-6		16	7.60E-6
4	SGTC_2008	4012253	4.31	172.0 µM	7.40E-6		17	8.21E-6
5	SGTC_671	0560-0003	4.04	407.0 µM	2.39E-5		10	2.62E-5
6	SGTC_676	falcarinol	4.04	140.0 µM	2.41E-5		52	2.64E-5
7	SGTC_639	0833-0042	4.02	114.0 µM	2.68E-5		42	2.93E-5
8	SGTC_1456	k015-0012	3.94	13.0 µM	3.70E-5		32	4.03E-5
9	SGTC_426	0988-0037	3.92	14.6 µM	4.08E-5	ERAD & cell cycle	33	4.44E-5
10	SGTC_2002	4023503	3.87	131.0 µM	5.10E-5	mitochondrial processes	33	5.54E-5
11	SGTC_1674	st016616	3.85	23.6 µM	5.44E-5		31	5.90E-5
12	SGTC_1739	st037196	3.75	92.5 µM	8.25E-5		30	8.91E-5
13	SGTC_2913	7966556	3.73	36.6 µM	8.84E-5	60S ribosome export	18	9.54E-5
14	SGTC_1341	1486-1360	3.66	280.0 µM	1.15E-4		35	1.24E-4
15	SGTC_2538	3',7'-epoxycaryophyllan-6-one	3.64	100.0 µM	1.28E-4		33	1.38E-4
16	SGTC_2613	3',4'-dimethoxydalbergione	3.57	24.6 µM	1.69E-4		39	1.81E-4
17	SGTC_3202	9113761	3.41	49.5 µM	3.08E-4		70	3.28E-4
18	SGTC_2947	9072639	3.37	7.7 µM	3.59E-4	tubulin folding & SWR complex	72	3.82E-4
19	SGTC_1347	1493-0251	3.33	600.0 nM	4.09E-4	mitochondrial response to ROS	35	4.33E-4
20	SGTC_2998	9066762	3.30	71.4 µM	4.62E-4	RPP1 & pyrimidine depletion	50	4.89E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.119	4.38E-12	YDL140C	RPO21	het	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.108	3.06E-10	YOR291W	YPK9	hom	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.101	5.37E-9	YPR151C	SUE1	hom	Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.098	1.47E-8	YFL017C	GNA1	het	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
0.096	2.40E-8	YDR031W	MIC14	hom	Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.092	8.83E-8	YOR054C	VHS3	hom	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.088	3.28E-7	YDL176W	YDL176W	hom	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.086	5.97E-7	YJL142C_d	IRC9_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.086	6.15E-7	YDR209C_d	YDR209C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.084	1.02E-6	YGR142W	BTN2	hom	v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
0.083	1.36E-6	YMR215W	GAS3	hom	Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.081	2.52E-6	YER060W-A	FCY22	hom	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.081	2.49E-6	YLL024C	SSA2	hom	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.078	5.40E-6	YPL190C	NAB3	het	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.077	7.51E-6	YMR008C	PLB1	hom	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol