YDR032C / PST2

Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR032C / PST2

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.77|P-value:5.06E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:51.10|P-value:0 ID:SGTC_96|Compound:0929-0093|FD-Score:3.10|P-value:6.58E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.15|P-value:7.76E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:5.66|P-value:2.95E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:3.28|P-value:3.50E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.77|P-value:7.63E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:4.14|P-value:1.00E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.24|P-value:4.01E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.19|P-value:6.87E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.10|P-value:9.31E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.17|P-value:8.52E-6 ID:SGTC_442|Compound:cape|FD-Score:-3.21|P-value:6.35E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.28|P-value:4.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.14|P-value:5.81E-4 ID:SGTC_458|Compound:nppb|FD-Score:-4.65|P-value:1.40E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.11|P-value:6.45E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.22|P-value:4.33E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.61|P-value:9.47E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.06|P-value:7.71E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.42|P-value:2.07E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.03|P-value:8.67E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.14|P-value:9.84E-6 ID:SGTC_622|Compound:1348-1566|FD-Score:3.64|P-value:8.66E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.26|P-value:3.78E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:4.38|P-value:3.21E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.11|P-value:6.39E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.65|P-value:8.32E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.93|P-value:2.47E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.41|P-value:2.76E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.78|P-value:4.40E-7 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.01|P-value:9.30E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.00|P-value:9.47E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.62|P-value:9.12E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.96|P-value:3.36E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.37|P-value:5.29E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.25|P-value:3.85E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.24|P-value:3.97E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.39|P-value:3.27E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.69|P-value:1.02E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.10|P-value:6.77E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.06|P-value:7.77E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.93|P-value:1.96E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.34|P-value:4.00E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.64|P-value:1.28E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.79|P-value:6.73E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.39|P-value:2.31E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.01|P-value:1.75E-5 ID:SGTC_2434|Compound:5670830|FD-Score:5.34|P-value:1.97E-8 ID:SGTC_2461|Compound:5755302|FD-Score:-4.10|P-value:1.85E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.57|P-value:1.63E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.88|P-value:3.14E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:7.56|P-value:4.61E-15 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.55|P-value:1.77E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:6.50|P-value:1.26E-11 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.95|P-value:2.29E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-4.15|P-value:1.46E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.53|P-value:1.91E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.42|P-value:2.97E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.33|P-value:2.85E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.83|P-value:3.82E-5 ID:SGTC_3057|Compound:9095946|FD-Score:3.99|P-value:1.95E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-3.50|P-value:2.22E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.77|P-value:5.06E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:51.10|P-value:0 ID:SGTC_96|Compound:0929-0093|FD-Score:3.10|P-value:6.58E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.15|P-value:7.76E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:5.66|P-value:2.95E-9 ID:SGTC_178|Compound:4092-0806|FD-Score:3.28|P-value:3.50E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.77|P-value:7.63E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:4.14|P-value:1.00E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.24|P-value:4.01E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.19|P-value:6.87E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.10|P-value:9.31E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.17|P-value:8.52E-6 ID:SGTC_442|Compound:cape|FD-Score:-3.21|P-value:6.35E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.28|P-value:4.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.14|P-value:5.81E-4 ID:SGTC_458|Compound:nppb|FD-Score:-4.65|P-value:1.40E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.11|P-value:6.45E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.22|P-value:4.33E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.61|P-value:9.47E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:3.06|P-value:7.71E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.42|P-value:2.07E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.03|P-value:8.67E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.14|P-value:9.84E-6 ID:SGTC_622|Compound:1348-1566|FD-Score:3.64|P-value:8.66E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.26|P-value:3.78E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:4.38|P-value:3.21E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.11|P-value:6.39E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.65|P-value:8.32E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.93|P-value:2.47E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.41|P-value:2.76E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.78|P-value:4.40E-7 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.01|P-value:9.30E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.00|P-value:9.47E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.62|P-value:9.12E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.96|P-value:3.36E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.37|P-value:5.29E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.25|P-value:3.85E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.24|P-value:3.97E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.39|P-value:3.27E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.69|P-value:1.02E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.10|P-value:6.77E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.06|P-value:7.77E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.93|P-value:1.96E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.34|P-value:4.00E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.64|P-value:1.28E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.79|P-value:6.73E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.39|P-value:2.31E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.01|P-value:1.75E-5 ID:SGTC_2434|Compound:5670830|FD-Score:5.34|P-value:1.97E-8 ID:SGTC_2461|Compound:5755302|FD-Score:-4.10|P-value:1.85E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.57|P-value:1.63E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.88|P-value:3.14E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:7.56|P-value:4.61E-15 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.55|P-value:1.77E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:6.50|P-value:1.26E-11 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.95|P-value:2.29E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-4.15|P-value:1.46E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.53|P-value:1.91E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.42|P-value:2.97E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.33|P-value:2.85E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.83|P-value:3.82E-5 ID:SGTC_3057|Compound:9095946|FD-Score:3.99|P-value:1.95E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-3.50|P-value:2.22E-4

Top fitness defect scores for YDR032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_20 0481-0013 51.10 4.9 µM 0 1 0
2 SGTC_2521 angolensin 7.56 13.4 µM 4.61E-15 1 2.07E-14
3 SGTC_2608 thymoquinone 6.50 42.7 µM 1.26E-11 4 4.03E-11
4 SGTC_106 0092-0003 5.66 11.6 µM 2.95E-9 copper-dependent oxidative stress 7 7.46E-9
5 SGTC_2434 5670830 5.34 169.9 µM 1.97E-8 6 4.60E-8
6 SGTC_1562 morin hydrate 4.93 59.1 µM 1.96E-7 3 4.12E-7
7 SGTC_1148 3909-7663 4.78 27.7 µM 4.40E-7 4 8.93E-7
8 SGTC_1021 4476-0760 4.41 85.3 µM 2.76E-6 15 5.16E-6
9 SGTC_857 0438-0306 4.38 1.4 µM 3.21E-6 copper-dependent oxidative stress 7 5.95E-6
10 SGTC_407 eburnamonine 4.17 100.0 µM 8.52E-6 10 1.51E-5
11 SGTC_621 3584-0052 4.14 32.1 µM 9.84E-6 23 1.73E-5
12 SGTC_195 4234-0266 4.14 16.6 µM 1.00E-5 29 1.76E-5
13 SGTC_2431 5490079 4.01 200.0 µM 1.75E-5 32 3.01E-5
14 SGTC_3057 9095946 3.99 49.5 µM 1.95E-5 Golgi 13 3.33E-5
15 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.95 70.0 µM 2.29E-5 redox potentiating 73 3.88E-5
16 SGTC_944 3370-0224 3.93 231.0 µM 2.47E-5 26 4.17E-5
17 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.88 3.7 µM 3.14E-5 86 5.25E-5
18 SGTC_3050 9093513 3.83 49.5 µM 3.82E-5 21 6.33E-5
19 SGTC_9 0092-0002 3.77 10.4 µM 5.06E-5 33 8.28E-5
20 SGTC_908 3448-7491 3.65 47.7 µM 8.32E-5 mitochondrial stress 140 1.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 7.02E-37 YNR026C SEC12 het Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER
0.215 1.85E-36 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.179 1.17E-25 YMR225C MRPL44 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.175 1.47E-24 YGR291C_d YGR291C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.161 7.59E-21 YKR076W ECM4 hom Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.155 1.51E-19 YNR075W COS10 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.154 3.04E-19 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.148 6.17E-18 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.147 9.76E-18 YDR327W_d YDR327W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
0.146 1.46E-17 YNL095C_p YNL095C_p hom Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
0.141 2.56E-16 YPL039W_p YPL039W_p hom Putative protein of unknown function; YPL039W is not an essential gene
0.141 2.94E-16 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.140 4.74E-16 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.138 8.92E-16 YOL070C NBA1 hom Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
0.133 1.02E-14 YCL001W-A_p YCL001W-A_p hom Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III