YDR035W / ARO3

3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR035W / ARO3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.81|P-value:1.02E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:4.76|P-value:4.67E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:8.30|P-value:3.36E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:6.06|P-value:1.18E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:6.63|P-value:1.88E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:7.70|P-value:3.80E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.54|P-value:6.48E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:9.84|P-value:3.06E-12 ID:SGTC_134|Compound:0269-0018|FD-Score:5.24|P-value:1.33E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.68|P-value:5.58E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:14.80|P-value:2.13E-25 ID:SGTC_180|Compound:1486-1293|FD-Score:23.70|P-value:1.65E-62 ID:SGTC_194|Compound:1486-1323|FD-Score:9.65|P-value:7.61E-12 ID:SGTC_205|Compound:1486-1330|FD-Score:10.60|P-value:6.98E-14 ID:SGTC_285|Compound:1486-1325|FD-Score:8.55|P-value:1.19E-9 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.93|P-value:6.58E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:7.35|P-value:1.47E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:5.13|P-value:1.75E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:5.36|P-value:9.44E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:6.32|P-value:5.26E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:9.11|P-value:9.51E-11 ID:SGTC_596|Compound:1155-0152|FD-Score:6.84|P-value:9.16E-7 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.55|P-value:7.76E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:5.02|P-value:2.40E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-4.99|P-value:2.04E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.37|P-value:9.18E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:5.31|P-value:1.09E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:5.90|P-value:1.96E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:5.03|P-value:2.31E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:6.26|P-value:6.25E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:6.99|P-value:5.38E-7 ID:SGTC_755|Compound:1995-0008|FD-Score:5.16|P-value:1.62E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.87|P-value:3.50E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:5.13|P-value:1.79E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:5.63|P-value:4.43E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:8.75|P-value:4.78E-10 ID:SGTC_844|Compound:0330-0132|FD-Score:4.68|P-value:5.59E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:5.14|P-value:1.73E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.36|P-value:9.50E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.79|P-value:1.09E-6 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:5.54|P-value:5.72E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:6.60|P-value:2.11E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:6.34|P-value:4.91E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.90|P-value:3.28E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-4.49|P-value:7.38E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:8.12|P-value:7.12E-9 ID:SGTC_1245|Compound:0418-0076|FD-Score:9.23|P-value:5.60E-11 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.63|P-value:6.32E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.58|P-value:5.06E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.97|P-value:2.71E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.26|P-value:1.26E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:7.24|P-value:2.19E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:7.88|P-value:1.90E-8 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-4.65|P-value:4.90E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:8.92|P-value:2.30E-10 ID:SGTC_1636|Compound:st007707|FD-Score:7.37|P-value:1.34E-7 ID:SGTC_1649|Compound:st011737|FD-Score:7.87|P-value:1.96E-8 ID:SGTC_1655|Compound:st012546|FD-Score:4.56|P-value:7.63E-4 ID:SGTC_1671|Compound:st016596|FD-Score:6.56|P-value:2.38E-6 ID:SGTC_1673|Compound:st016611|FD-Score:4.70|P-value:5.43E-4 ID:SGTC_1697|Compound:st025554|FD-Score:7.41|P-value:1.15E-7 ID:SGTC_1715|Compound:st032160|FD-Score:6.13|P-value:9.55E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-5.71|P-value:2.66E-5 ID:SGTC_1743|Compound:st037606|FD-Score:5.40|P-value:8.54E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.28|P-value:5.88E-6 ID:SGTC_1748|Compound:st037455|FD-Score:7.67|P-value:4.19E-8 ID:SGTC_1757|Compound:st041620|FD-Score:9.21|P-value:6.03E-11 ID:SGTC_1775|Compound:st081588|FD-Score:-4.41|P-value:8.87E-4 ID:SGTC_1779|Compound:st039427|FD-Score:5.59|P-value:4.96E-5 ID:SGTC_1797|Compound:st048695|FD-Score:9.69|P-value:6.20E-12 ID:SGTC_1835|Compound:st008666|FD-Score:4.83|P-value:3.85E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.06|P-value:2.16E-4 ID:SGTC_1975|Compound:st070967|FD-Score:5.77|P-value:2.86E-5 ID:SGTC_2036|Compound:5160441|FD-Score:6.51|P-value:2.81E-6 ID:SGTC_2038|Compound:4100038|FD-Score:7.34|P-value:1.48E-7 ID:SGTC_2056|Compound:5235370|FD-Score:5.87|P-value:2.12E-5 ID:SGTC_2093|Compound:5331342|FD-Score:5.80|P-value:2.67E-5 ID:SGTC_2094|Compound:5332512|FD-Score:11.80|P-value:9.38E-17 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.69|P-value:3.95E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.61|P-value:4.65E-5 ID:SGTC_2254|Compound:7938975|FD-Score:6.34|P-value:4.83E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-4.38|P-value:9.45E-4 ID:SGTC_2286|Compound:7945697|FD-Score:6.48|P-value:3.12E-6 ID:SGTC_2296|Compound:7971656|FD-Score:4.53|P-value:8.21E-4 ID:SGTC_2301|Compound:7769476|FD-Score:6.06|P-value:1.21E-5 ID:SGTC_2318|Compound:6029776|FD-Score:6.06|P-value:1.18E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.22|P-value:7.16E-6 ID:SGTC_2340|Compound:7987427|FD-Score:5.15|P-value:1.69E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.54|P-value:7.90E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.94|P-value:1.49E-8 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.19|P-value:1.49E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.18|P-value:1.54E-4 ID:SGTC_2437|Compound:5741531|FD-Score:6.46|P-value:3.34E-6 ID:SGTC_2445|Compound:5742597|FD-Score:5.26|P-value:1.25E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:6.05|P-value:1.22E-5 ID:SGTC_2472|Compound:5377652|FD-Score:6.88|P-value:7.87E-7 ID:SGTC_2486|Compound:5283202|FD-Score:5.45|P-value:7.36E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.80|P-value:4.16E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:9.18|P-value:7.17E-11 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:5.27|P-value:1.20E-4 ID:SGTC_2517|Compound:totarol|FD-Score:5.22|P-value:1.38E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:5.43|P-value:7.79E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.85|P-value:3.68E-4 ID:SGTC_2523|Compound:spermine|FD-Score:5.25|P-value:1.28E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:9.31|P-value:3.80E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:7.17|P-value:2.85E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:7.41|P-value:1.16E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.74|P-value:4.85E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.46|P-value:3.27E-6 ID:SGTC_2699|Compound:st077704|FD-Score:5.32|P-value:1.07E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.01|P-value:1.40E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:9.31|P-value:3.81E-11 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:14.30|P-value:5.01E-24 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.48|P-value:9.26E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.97|P-value:1.56E-5 ID:SGTC_2838|Compound:9002687|FD-Score:5.32|P-value:1.04E-4 ID:SGTC_2939|Compound:9044578|FD-Score:11.00|P-value:6.87E-15 ID:SGTC_2991|Compound:9074669|FD-Score:6.22|P-value:7.20E-6 ID:SGTC_3157|Compound:9099274|FD-Score:-4.55|P-value:6.32E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-5.44|P-value:5.84E-5 ID:SGTC_3308|Compound:9128332|FD-Score:6.81|P-value:1.02E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:6.81|P-value:1.02E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:4.76|P-value:4.67E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:8.30|P-value:3.36E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:6.06|P-value:1.18E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:6.63|P-value:1.88E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:7.70|P-value:3.80E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.54|P-value:6.48E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:9.84|P-value:3.06E-12 ID:SGTC_134|Compound:0269-0018|FD-Score:5.24|P-value:1.33E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.68|P-value:5.58E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:14.80|P-value:2.13E-25 ID:SGTC_180|Compound:1486-1293|FD-Score:23.70|P-value:1.65E-62 ID:SGTC_194|Compound:1486-1323|FD-Score:9.65|P-value:7.61E-12 ID:SGTC_205|Compound:1486-1330|FD-Score:10.60|P-value:6.98E-14 ID:SGTC_285|Compound:1486-1325|FD-Score:8.55|P-value:1.19E-9 ID:SGTC_465|Compound:cgp-37157|FD-Score:6.93|P-value:6.58E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:7.35|P-value:1.47E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:5.13|P-value:1.75E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:5.36|P-value:9.44E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:6.32|P-value:5.26E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:9.11|P-value:9.51E-11 ID:SGTC_596|Compound:1155-0152|FD-Score:6.84|P-value:9.16E-7 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.55|P-value:7.76E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:5.02|P-value:2.40E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-4.99|P-value:2.04E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.37|P-value:9.18E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:5.31|P-value:1.09E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:5.90|P-value:1.96E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:5.03|P-value:2.31E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:6.26|P-value:6.25E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:6.99|P-value:5.38E-7 ID:SGTC_755|Compound:1995-0008|FD-Score:5.16|P-value:1.62E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.87|P-value:3.50E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:5.13|P-value:1.79E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:5.63|P-value:4.43E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:8.75|P-value:4.78E-10 ID:SGTC_844|Compound:0330-0132|FD-Score:4.68|P-value:5.59E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:5.14|P-value:1.73E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.36|P-value:9.50E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.79|P-value:1.09E-6 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:5.54|P-value:5.72E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:6.60|P-value:2.11E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:6.34|P-value:4.91E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.90|P-value:3.28E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-4.49|P-value:7.38E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:8.12|P-value:7.12E-9 ID:SGTC_1245|Compound:0418-0076|FD-Score:9.23|P-value:5.60E-11 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.63|P-value:6.32E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.58|P-value:5.06E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.97|P-value:2.71E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:5.26|P-value:1.26E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:7.24|P-value:2.19E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:7.88|P-value:1.90E-8 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-4.65|P-value:4.90E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:8.92|P-value:2.30E-10 ID:SGTC_1636|Compound:st007707|FD-Score:7.37|P-value:1.34E-7 ID:SGTC_1649|Compound:st011737|FD-Score:7.87|P-value:1.96E-8 ID:SGTC_1655|Compound:st012546|FD-Score:4.56|P-value:7.63E-4 ID:SGTC_1671|Compound:st016596|FD-Score:6.56|P-value:2.38E-6 ID:SGTC_1673|Compound:st016611|FD-Score:4.70|P-value:5.43E-4 ID:SGTC_1697|Compound:st025554|FD-Score:7.41|P-value:1.15E-7 ID:SGTC_1715|Compound:st032160|FD-Score:6.13|P-value:9.55E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-5.71|P-value:2.66E-5 ID:SGTC_1743|Compound:st037606|FD-Score:5.40|P-value:8.54E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.28|P-value:5.88E-6 ID:SGTC_1748|Compound:st037455|FD-Score:7.67|P-value:4.19E-8 ID:SGTC_1757|Compound:st041620|FD-Score:9.21|P-value:6.03E-11 ID:SGTC_1775|Compound:st081588|FD-Score:-4.41|P-value:8.87E-4 ID:SGTC_1779|Compound:st039427|FD-Score:5.59|P-value:4.96E-5 ID:SGTC_1797|Compound:st048695|FD-Score:9.69|P-value:6.20E-12 ID:SGTC_1835|Compound:st008666|FD-Score:4.83|P-value:3.85E-4 ID:SGTC_1941|Compound:st076221|FD-Score:5.06|P-value:2.16E-4 ID:SGTC_1975|Compound:st070967|FD-Score:5.77|P-value:2.86E-5 ID:SGTC_2036|Compound:5160441|FD-Score:6.51|P-value:2.81E-6 ID:SGTC_2038|Compound:4100038|FD-Score:7.34|P-value:1.48E-7 ID:SGTC_2056|Compound:5235370|FD-Score:5.87|P-value:2.12E-5 ID:SGTC_2093|Compound:5331342|FD-Score:5.80|P-value:2.67E-5 ID:SGTC_2094|Compound:5332512|FD-Score:11.80|P-value:9.38E-17 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.69|P-value:3.95E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.61|P-value:4.65E-5 ID:SGTC_2254|Compound:7938975|FD-Score:6.34|P-value:4.83E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-4.38|P-value:9.45E-4 ID:SGTC_2286|Compound:7945697|FD-Score:6.48|P-value:3.12E-6 ID:SGTC_2296|Compound:7971656|FD-Score:4.53|P-value:8.21E-4 ID:SGTC_2301|Compound:7769476|FD-Score:6.06|P-value:1.21E-5 ID:SGTC_2318|Compound:6029776|FD-Score:6.06|P-value:1.18E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.22|P-value:7.16E-6 ID:SGTC_2340|Compound:7987427|FD-Score:5.15|P-value:1.69E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.54|P-value:7.90E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.94|P-value:1.49E-8 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.19|P-value:1.49E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.18|P-value:1.54E-4 ID:SGTC_2437|Compound:5741531|FD-Score:6.46|P-value:3.34E-6 ID:SGTC_2445|Compound:5742597|FD-Score:5.26|P-value:1.25E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:6.05|P-value:1.22E-5 ID:SGTC_2472|Compound:5377652|FD-Score:6.88|P-value:7.87E-7 ID:SGTC_2486|Compound:5283202|FD-Score:5.45|P-value:7.36E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.80|P-value:4.16E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:9.18|P-value:7.17E-11 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:5.27|P-value:1.20E-4 ID:SGTC_2517|Compound:totarol|FD-Score:5.22|P-value:1.38E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:5.43|P-value:7.79E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.85|P-value:3.68E-4 ID:SGTC_2523|Compound:spermine|FD-Score:5.25|P-value:1.28E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:9.31|P-value:3.80E-11 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:7.17|P-value:2.85E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:7.41|P-value:1.16E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.74|P-value:4.85E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.46|P-value:3.27E-6 ID:SGTC_2699|Compound:st077704|FD-Score:5.32|P-value:1.07E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.01|P-value:1.40E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:9.31|P-value:3.81E-11 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:14.30|P-value:5.01E-24 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.48|P-value:9.26E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.97|P-value:1.56E-5 ID:SGTC_2838|Compound:9002687|FD-Score:5.32|P-value:1.04E-4 ID:SGTC_2939|Compound:9044578|FD-Score:11.00|P-value:6.87E-15 ID:SGTC_2991|Compound:9074669|FD-Score:6.22|P-value:7.20E-6 ID:SGTC_3157|Compound:9099274|FD-Score:-4.55|P-value:6.32E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-5.44|P-value:5.84E-5 ID:SGTC_3308|Compound:9128332|FD-Score:6.81|P-value:1.02E-6

Top fitness defect scores for YDR035W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_180 1486-1293 23.70 102.8 µM 1.65E-62 1 5.70E-125
2 SGTC_176 1486-1328 14.80 72.8 µM 2.13E-25 3 9.69E-50
3 SGTC_2758 dehydroepiandrosterone 14.30 69.3 µM 5.01E-24 9 5.81E-47
4 SGTC_2094 5332512 11.80 191.7 µM 9.38E-17 1 3.00E-32
5 SGTC_2939 9044578 11.00 71.4 µM 6.87E-15 7 1.76E-28
6 SGTC_205 1486-1330 10.60 71.9 µM 6.98E-14 1 1.90E-26
7 SGTC_89 0302-0250 9.84 142.1 µM 3.06E-12 1 3.90E-23
8 SGTC_1797 st048695 9.69 56.8 µM 6.20E-12 NEO1 18 1.62E-22
9 SGTC_194 1486-1323 9.65 56.9 µM 7.61E-12 1 2.45E-22
10 SGTC_2524 avocatin b 9.31 10.6 µM 3.80E-11 8 6.28E-21
11 SGTC_2752 diclazuril 9.31 33.1 µM 3.81E-11 27 6.32E-21
12 SGTC_1245 0418-0076 9.23 17.2 µM 5.60E-11 ERG2 1 1.37E-20
13 SGTC_1757 st041620 9.21 31.8 µM 6.03E-11 4 1.59E-20
14 SGTC_2500 5-alpha-androstan-3,17-dione 9.18 61.4 µM 7.17E-11 1 2.26E-20
15 SGTC_583 1488-1091 9.11 88.9 µM 9.51E-11 1 3.98E-20
16 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 8.92 54.9 µM 2.30E-10 redox potentiating 15 2.36E-19
17 SGTC_834 0312-0008 8.75 75.7 µM 4.78E-10 NEO1 6 1.03E-18
18 SGTC_285 1486-1325 8.55 46.0 µM 1.19E-9 4 6.42E-18
19 SGTC_24 0417-1663 8.30 219.0 µM 3.36E-9 3 5.20E-17
20 SGTC_1241 0364-0022 8.12 50.8 µM 7.12E-9 ERG2 2 2.36E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.558 3.45E-273 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.553 5.28E-268 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.546 3.87E-258 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.532 8.59E-244 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.527 1.09E-238 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.516 1.09E-226 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.486 5.31E-198 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.485 1.62E-196 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.450 1.39E-165 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.442 4.09E-160 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.427 9.61E-149 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.369 1.82E-108 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.239 9.00E-45 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.160 9.76E-21 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.129 6.14E-14 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches