HIPHOP chemogenomics database

YDR037W / KRS1

Lysyl-tRNA synthetase

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR037W / KRS1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR037W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2942	9052777	7.60	62.2 µM	3.54E-22		1	1.47E-14	1.66
2	SGTC_516	3992-2719	7.31	87.3 µM	1.15E-20		1	1.32E-13	2.27
3	SGTC_1270	0831-1170	6.50	17.3 µM	9.42E-17		1	3.92E-11	2.02
4	SGTC_2297	7971671	5.80	152.3 µM	1.08E-13	RNA processing & uracil transport	3	3.36E-9	0.56
5	SGTC_1268	0828-0275	5.43	2.5 µM	3.07E-12		3	2.80E-8	0.55
6	SGTC_2839	9003951	4.79	26.0 µM	6.29E-10		1	8.20E-7	0.88
7	SGTC_473	2-arachidonoylglycerol	3.99	10.0 µM	2.08E-7		4	3.28E-5	0.14
8	SGTC_2574	2',4'-dihydroxychalcone	3.83	14.6 µM	6.05E-7		11	6.48E-5	0.00
9	SGTC_1276	0871-0068	3.80	94.2 µM	7.17E-7		8	7.23E-5	0.23
10	SGTC_2292	7671323	3.63	168.1 µM	2.02E-6	RNA processing & uracil transport	14	1.40E-4	0.02
11	SGTC_874	0599-0792	3.53	117.0 µM	3.77E-6		9	2.09E-4	0.08
12	SGTC_967	1306-0166	3.09	352.0 µM	4.45E-5		6	0.00102	0.06
13	SGTC_727	3032-0951	3.06	202.0 µM	5.20E-5		7	0.00112	0.23
14	SGTC_1288	0973-0013	3.02	65.5 µM	6.12E-5		7	0.00125	0.02
15	SGTC_2803	7707263	2.93	71.4 µM	9.96E-5		10	0.00171	0.06
16	SGTC_1693	xanthone	2.92	101.9 µM	1.01E-4	DNA damage response	21	0.00172	0.03
17	SGTC_1710	st031758	2.89	61.5 µM	1.19E-4		14	0.00191	0.09
18	SGTC_2847	9005661	2.83	71.4 µM	1.57E-4		5	0.00229	0.06
19	SGTC_1383	3049-0032	2.83	20.7 µM	1.60E-4	60S ribosome export	28	0.00231	0.05
20	SGTC_2564	betulinic acid	2.80	100.0 µM	1.87E-4		24	0.00256	0.05

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.198	4.64E-31	YKL122C	SRP21	het	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.181	4.45E-26	YGR149W_p	YGR149W_p	hom	Putative protein of unknown function; predicted to be an integal membrane protein
0.170	4.14E-23	YMR111C	YMR111C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.165	5.79E-22	YLR016C	PML1	hom	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.159	2.45E-20	YMR210W	YMR210W	hom	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.156	1.23E-19	YDL224C	WHI4	hom	Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.155	1.91E-19	YGL081W_p	YGL081W_p	hom	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.147	8.76E-18	YDR013W	PSF1	het	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.146	1.45E-17	YLR353W	BUD8	hom	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.146	1.53E-17	YFR042W	KEG1	het	Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.146	1.58E-17	YJL122W	ALB1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.144	3.99E-17	YJR051W	OSM1	hom	Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
0.138	1.09E-15	YML011C	RAD33	hom	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.137	1.51E-15	YDR044W	HEM13	het	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.137	1.72E-15	YGR032W	GSC2	hom	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)