YDR042C_p

Putative protein of unknown function; expression is increased in ssu72-ts69 mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR042C / YDR042C

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:2.82|P-value:6.93E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.45|P-value:4.43E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.01|P-value:2.90E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.41|P-value:5.39E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.39|P-value:5.83E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:2.95|P-value:4.07E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.74|P-value:3.61E-8 ID:SGTC_496|Compound:calpeptin|FD-Score:3.07|P-value:2.45E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:2.76|P-value:8.59E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.29|P-value:5.57E-7 ID:SGTC_760|Compound:0568-0725|FD-Score:4.09|P-value:1.69E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:4.37|P-value:3.54E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.79|P-value:2.30E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:-2.82|P-value:6.16E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:2.94|P-value:4.19E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.08|P-value:2.37E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.86|P-value:5.31E-4 ID:SGTC_1986|Compound:st071812|FD-Score:2.91|P-value:4.76E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.37|P-value:5.87E-5 ID:SGTC_2136|Compound:5328288|FD-Score:2.77|P-value:8.34E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.52|P-value:1.20E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.01|P-value:3.25E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.06|P-value:2.61E-4 ID:SGTC_2790|Compound:5423970|FD-Score:2.85|P-value:6.13E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-2.80|P-value:6.79E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.71|P-value:9.82E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.49|P-value:3.29E-5 ID:SGTC_3015|Compound:9080845|FD-Score:2.75|P-value:9.06E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-2.82|P-value:6.31E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.51|P-value:3.00E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.32|P-value:8.33E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.05|P-value:2.73E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.87|P-value:5.66E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.81|P-value:6.56E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.82|P-value:6.93E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.45|P-value:4.43E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.01|P-value:2.90E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.41|P-value:5.39E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.39|P-value:5.83E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:2.95|P-value:4.07E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.74|P-value:3.61E-8 ID:SGTC_496|Compound:calpeptin|FD-Score:3.07|P-value:2.45E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:2.76|P-value:8.59E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.29|P-value:5.57E-7 ID:SGTC_760|Compound:0568-0725|FD-Score:4.09|P-value:1.69E-6 ID:SGTC_762|Compound:1165-0429|FD-Score:4.37|P-value:3.54E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.79|P-value:2.30E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:-2.82|P-value:6.16E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:2.94|P-value:4.19E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.08|P-value:2.37E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.86|P-value:5.31E-4 ID:SGTC_1986|Compound:st071812|FD-Score:2.91|P-value:4.76E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.37|P-value:5.87E-5 ID:SGTC_2136|Compound:5328288|FD-Score:2.77|P-value:8.34E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.52|P-value:1.20E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.01|P-value:3.25E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.06|P-value:2.61E-4 ID:SGTC_2790|Compound:5423970|FD-Score:2.85|P-value:6.13E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-2.80|P-value:6.79E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.71|P-value:9.82E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.49|P-value:3.29E-5 ID:SGTC_3015|Compound:9080845|FD-Score:2.75|P-value:9.06E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-2.82|P-value:6.31E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.51|P-value:3.00E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.32|P-value:8.33E-5 ID:SGTC_3085|Compound:9117376|FD-Score:3.05|P-value:2.73E-4 ID:SGTC_3209|Compound:9113616|FD-Score:2.87|P-value:5.66E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.81|P-value:6.56E-4

Top fitness defect scores for YDR042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_457 grayanotoxin iii 4.74 135.0 µM 3.61E-8 32 1.07E-6
2 SGTC_762 1165-0429 4.37 115.0 µM 3.54E-7 TSC3-RPN4 11 6.33E-6
3 SGTC_758 0868-0029 4.29 16.0 µM 5.57E-7 4 9.02E-6
4 SGTC_760 0568-0725 4.09 82.9 µM 1.69E-6 8 2.15E-5
5 SGTC_331 k048-0133 3.45 24.5 µM 4.43E-5 RSC & ERG11 19 2.77E-4
6 SGTC_374 0880-0231 3.41 82.3 µM 5.39E-5 iron homeostasis 45 3.23E-4
7 SGTC_453 enantio-paf c16 3.39 10.0 µM 5.83E-5 197 3.43E-4
8 SGTC_3062 9077494 3.32 49.5 µM 8.33E-5 mitochondrial response to ROS 52 4.54E-4
9 SGTC_1527 coumarin 3.08 137.0 µM 2.37E-4 61 0.00103
10 SGTC_496 calpeptin 3.07 138.0 µM 2.45E-4 48 0.00106
11 SGTC_2674 ligustilide 3.06 100.0 µM 2.61E-4 29 0.00112
12 SGTC_3085 9117376 3.05 49.5 µM 2.73E-4 44 0.00116
13 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.01 100.0 µM 3.25E-4 75 0.00132
14 SGTC_455 paf C-16 2.95 10.0 µM 4.07E-4 74 0.00158
15 SGTC_823 0417-1665 2.94 178.0 µM 4.19E-4 81 0.00162
16 SGTC_1986 st071812 2.91 45.0 µM 4.76E-4 40 0.00179
17 SGTC_3209 9113616 2.87 49.5 µM 5.66E-4 93 0.00205
18 SGTC_2790 5423970 2.85 71.4 µM 6.13E-4 endomembrane recycling 140 0.00218
19 SGTC_182 3448-4371 2.82 550.5 µM 6.93E-4 72 0.00241
20 SGTC_2136 5328288 2.77 199.3 µM 8.34E-4 67 0.00278

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.54E-27 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.163 2.04E-21 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.157 6.55E-20 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.156 1.24E-19 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.144 5.08E-17 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.129 5.79E-14 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.129 7.44E-14 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.127 1.58E-13 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.126 2.11E-13 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.126 2.34E-13 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.125 4.56E-13 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.124 4.65E-13 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.123 8.31E-13 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.119 4.77E-12 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.118 7.60E-12 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability