YDR046C / BAP3

Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR046C / BAP3

Click on Significant Values for Screen Details ID:SGTC_417|Compound:st075190|FD-Score:3.61|P-value:8.41E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:4.65|P-value:6.76E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:3.96|P-value:1.88E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.53|P-value:7.06E-12 ID:SGTC_747|Compound:3448-8087|FD-Score:5.26|P-value:2.43E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.35|P-value:4.72E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.74|P-value:7.19E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.90|P-value:2.53E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.09|P-value:8.74E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.76|P-value:4.47E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.01|P-value:8.25E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.24|P-value:5.11E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.49|P-value:1.39E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.12|P-value:5.62E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.86|P-value:2.91E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.15|P-value:5.01E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.06|P-value:9.83E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.40|P-value:1.95E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.93|P-value:2.52E-7 ID:SGTC_2800|Compound:7887935|FD-Score:3.04|P-value:7.45E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.12|P-value:7.97E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.39|P-value:2.05E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.14|P-value:5.24E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.44|P-value:2.44E-4 ID:SGTC_3169|Compound:9102970|FD-Score:-3.38|P-value:3.03E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.71|P-value:8.22E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-4.17|P-value:1.11E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-4.39|P-value:3.99E-6 ID:SGTC_417|Compound:st075190|FD-Score:3.61|P-value:8.41E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:4.65|P-value:6.76E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:3.96|P-value:1.88E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:6.53|P-value:7.06E-12 ID:SGTC_747|Compound:3448-8087|FD-Score:5.26|P-value:2.43E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.35|P-value:4.72E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.74|P-value:7.19E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.90|P-value:2.53E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.09|P-value:8.74E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.76|P-value:4.47E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.01|P-value:8.25E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.24|P-value:5.11E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.49|P-value:1.39E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.12|P-value:5.62E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.86|P-value:2.91E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.15|P-value:5.01E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.06|P-value:9.83E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.40|P-value:1.95E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.93|P-value:2.52E-7 ID:SGTC_2800|Compound:7887935|FD-Score:3.04|P-value:7.45E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.12|P-value:7.97E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.39|P-value:2.05E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.14|P-value:5.24E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.44|P-value:2.44E-4 ID:SGTC_3169|Compound:9102970|FD-Score:-3.38|P-value:3.03E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.71|P-value:8.22E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-4.17|P-value:1.11E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-4.39|P-value:3.99E-6

Top fitness defect scores for YDR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_742 0kpi-0133 6.53 140.0 µM 7.06E-12 ERG2 5 3.38E-11
2 SGTC_747 3448-8087 5.26 38.7 µM 2.43E-8 7 7.16E-8
3 SGTC_737 1950-0117 4.65 57.9 µM 6.76E-7 13 1.63E-6
4 SGTC_739 1486-1183 3.96 203.0 µM 1.88E-5 16 3.70E-5
5 SGTC_811 0416-0114 3.90 265.0 µM 2.53E-5 23 4.90E-5
6 SGTC_2487 5918373 3.86 44.0 µM 2.91E-5 17 5.58E-5
7 SGTC_1119 parthenolide 3.76 318.5 nM 4.47E-5 TSC3-RPN4 43 8.34E-5
8 SGTC_417 st075190 3.61 100.0 µM 8.41E-5 15 1.51E-4
9 SGTC_2788 5282734 3.52 71.4 µM 1.25E-4 68 2.20E-4
10 SGTC_2164 5685496 3.49 200.0 µM 1.39E-4 31 2.41E-4
11 SGTC_2783 7738165 3.40 71.4 µM 1.95E-4 48 3.33E-4
12 SGTC_2871 9038510 3.39 13.0 µM 2.05E-4 40 3.48E-4
13 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.15 3.7 µM 5.01E-4 174 8.05E-4
14 SGTC_2877 9040724 3.14 71.4 µM 5.24E-4 42 8.41E-4
15 SGTC_2469 5655019 3.12 90.8 µM 5.62E-4 53 8.97E-4
16 SGTC_2800 7887935 3.04 81.8 µM 7.45E-4 RPP1 & pyrimidine depletion 76 0.00117
17 SGTC_1344 1488-0097 3.01 29.1 µM 8.25E-4 53 0.00129
18 SGTC_846 0335-0850 2.89 148.0 µM 0.00126 ubiquinone biosynthesis & proteasome 75 0.00192
19 SGTC_499 genistein 2.89 192.0 µM 0.00128 13 0.00194
20 SGTC_212 3807-4682 2.87 38.8 µM 0.00135 tubulin folding & SWR complex 157 0.00205

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 4.92E-32 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.168 1.46E-22 YER065C ICL1 hom Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
0.161 5.54E-21 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.155 1.43E-19 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.149 3.75E-18 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.148 8.27E-18 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.143 8.18E-17 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.141 2.45E-16 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.140 4.38E-16 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.139 6.48E-16 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.138 8.97E-16 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.136 2.22E-15 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.135 5.02E-15 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.134 5.45E-15 YDR036C EHD3 hom 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.132 1.92E-14 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication