YDR051C / DET1

Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR051C / DET1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.95|P-value:9.41E-11 ID:SGTC_32|Compound:0928-0142|FD-Score:3.09|P-value:4.83E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.86|P-value:1.70E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:2.98|P-value:7.18E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.05|P-value:5.45E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.24|P-value:2.72E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.01|P-value:8.61E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:3.94|P-value:1.24E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.82|P-value:2.06E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.28|P-value:2.18E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.96|P-value:1.07E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:4.82|P-value:1.26E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:3.94|P-value:1.23E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-2.88|P-value:9.93E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.94|P-value:1.17E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.05|P-value:5.50E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.16|P-value:3.63E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.19|P-value:3.78E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.97|P-value:7.31E-4 ID:SGTC_1975|Compound:st070967|FD-Score:2.92|P-value:8.93E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.11|P-value:4.29E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-2.97|P-value:7.22E-4 ID:SGTC_2120|Compound:5538279|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.34|P-value:1.75E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.71E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:1.38E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-5.76|P-value:3.24E-10 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.58|P-value:6.11E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-3.34|P-value:1.69E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-5.27|P-value:8.13E-9 ID:SGTC_3141|Compound:9094609|FD-Score:5.26|P-value:9.28E-9 ID:SGTC_3143|Compound:9086658|FD-Score:5.61|P-value:9.47E-10 ID:SGTC_3145|Compound:9085516|FD-Score:3.49|P-value:9.43E-5 ID:SGTC_3192|Compound:9110362|FD-Score:4.33|P-value:1.80E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-3.78|P-value:2.54E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:5.95|P-value:9.41E-11 ID:SGTC_32|Compound:0928-0142|FD-Score:3.09|P-value:4.83E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.86|P-value:1.70E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:2.98|P-value:7.18E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.05|P-value:5.45E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.24|P-value:2.72E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.01|P-value:8.61E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:3.94|P-value:1.24E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.82|P-value:2.06E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.28|P-value:2.18E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.96|P-value:1.07E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:4.82|P-value:1.26E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:3.94|P-value:1.23E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-2.88|P-value:9.93E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.94|P-value:1.17E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.05|P-value:5.50E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.16|P-value:3.63E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.19|P-value:3.78E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.97|P-value:7.31E-4 ID:SGTC_1975|Compound:st070967|FD-Score:2.92|P-value:8.93E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.11|P-value:4.29E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-2.97|P-value:7.22E-4 ID:SGTC_2120|Compound:5538279|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.34|P-value:1.75E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.71E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:1.38E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-5.76|P-value:3.24E-10 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.58|P-value:6.11E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-3.34|P-value:1.69E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-5.27|P-value:8.13E-9 ID:SGTC_3141|Compound:9094609|FD-Score:5.26|P-value:9.28E-9 ID:SGTC_3143|Compound:9086658|FD-Score:5.61|P-value:9.47E-10 ID:SGTC_3145|Compound:9085516|FD-Score:3.49|P-value:9.43E-5 ID:SGTC_3192|Compound:9110362|FD-Score:4.33|P-value:1.80E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-3.78|P-value:2.54E-5

Top fitness defect scores for YDR051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 5.95 19.8 µM 9.41E-11 16 1.32E-9
2 SGTC_3143 9086658 5.61 49.5 µM 9.47E-10 11 9.94E-9
3 SGTC_3141 9094609 5.26 49.5 µM 9.28E-9 iron homeostasis 14 7.33E-8
4 SGTC_929 2805-0021 4.82 398.0 µM 1.26E-7 4 7.22E-7
5 SGTC_3192 9110362 4.33 49.5 µM 1.80E-6 mitochondrial processes 8 7.43E-6
6 SGTC_1344 1488-0097 4.19 29.1 µM 3.78E-6 12 1.43E-5
7 SGTC_931 2812-0076 3.94 566.0 µM 1.23E-5 26 4.01E-5
8 SGTC_621 3584-0052 3.94 32.1 µM 1.24E-5 27 4.05E-5
9 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.77 3.7 µM 2.71E-5 97 8.03E-5
10 SGTC_3145 9085516 3.49 49.5 µM 9.43E-5 fatty acid desaturase (OLE1) 44 2.40E-4
11 SGTC_2123 5259487 3.34 200.0 µM 1.75E-4 36 4.15E-4
12 SGTC_1308 1187-1617 3.16 41.4 µM 3.63E-4 fatty acid desaturase (OLE1) 84 7.88E-4
13 SGTC_32 0928-0142 3.09 34.1 µM 4.83E-4 TSC3-RPN4 30 0.00101
14 SGTC_430 0958-0115 3.05 16.4 µM 5.45E-4 79 0.00113
15 SGTC_1170 0310-0127 3.05 64.8 µM 5.50E-4 70 0.00114
16 SGTC_156 3474-0145 2.98 5.6 µM 7.18E-4 endomembrane recycling 97 0.00144
17 SGTC_2120 5538279 2.97 152.0 µM 7.43E-4 47 0.00148
18 SGTC_1975 st070967 2.92 30.8 µM 8.93E-4 94 0.00174
19 SGTC_1973 st070275 2.84 50.2 µM 0.00119 53 0.00225
20 SGTC_837 0091-0265 2.74 12.5 µM 0.00168 ubiquinone biosynthesis & proteasome 83 0.00305

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 5.25E-43 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.230 1.45E-41 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.227 1.54E-40 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.219 1.18E-37 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.213 1.30E-35 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.211 3.47E-35 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.211 3.98E-35 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.194 9.72E-30 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.191 7.65E-29 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.182 1.90E-26 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.181 2.97E-26 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.179 1.18E-25 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.178 2.77E-25 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.165 7.81E-22 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.161 6.05E-21 YPL264C_p YPL264C_p hom Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene