YDR055W / PST1

Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR055W / PST1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.45|P-value:3.39E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.46|P-value:3.25E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.42|P-value:3.67E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.66|P-value:1.88E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.39|P-value:4.07E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.89|P-value:1.28E-18 ID:SGTC_834|Compound:0312-0008|FD-Score:4.01|P-value:3.94E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.47|P-value:3.14E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.32|P-value:5.36E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.28|P-value:6.12E-4 ID:SGTC_1637|Compound:st007924|FD-Score:4.24|P-value:1.49E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.30|P-value:1.14E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.55|P-value:2.33E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.56|P-value:3.62E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-3.79|P-value:1.15E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.86|P-value:7.26E-5 ID:SGTC_2022|Compound:5136654|FD-Score:6.15|P-value:7.29E-10 ID:SGTC_2164|Compound:5685496|FD-Score:3.77|P-value:1.03E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.42|P-value:8.45E-6 ID:SGTC_2360|Compound:9040895|FD-Score:3.19|P-value:8.12E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.47|P-value:6.70E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-5.10|P-value:3.35E-7 ID:SGTC_2427|Compound:5545055|FD-Score:-3.54|P-value:2.86E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-5.11|P-value:3.26E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.37|P-value:5.36E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.68|P-value:1.75E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.11|P-value:3.16E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.57|P-value:4.28E-6 ID:SGTC_3119|Compound:9125183|FD-Score:-3.28|P-value:7.27E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.39|P-value:4.85E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.45|P-value:3.39E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.46|P-value:3.25E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.42|P-value:3.67E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.66|P-value:1.88E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.39|P-value:4.07E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.89|P-value:1.28E-18 ID:SGTC_834|Compound:0312-0008|FD-Score:4.01|P-value:3.94E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.47|P-value:3.14E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.32|P-value:5.36E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.28|P-value:6.12E-4 ID:SGTC_1637|Compound:st007924|FD-Score:4.24|P-value:1.49E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.30|P-value:1.14E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.55|P-value:2.33E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.56|P-value:3.62E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-3.79|P-value:1.15E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.86|P-value:7.26E-5 ID:SGTC_2022|Compound:5136654|FD-Score:6.15|P-value:7.29E-10 ID:SGTC_2164|Compound:5685496|FD-Score:3.77|P-value:1.03E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.42|P-value:8.45E-6 ID:SGTC_2360|Compound:9040895|FD-Score:3.19|P-value:8.12E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-4.47|P-value:6.70E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-5.10|P-value:3.35E-7 ID:SGTC_2427|Compound:5545055|FD-Score:-3.54|P-value:2.86E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-5.11|P-value:3.26E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.37|P-value:5.36E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.68|P-value:1.75E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.11|P-value:3.16E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-4.57|P-value:4.28E-6 ID:SGTC_3119|Compound:9125183|FD-Score:-3.28|P-value:7.27E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.39|P-value:4.85E-4

Top fitness defect scores for YDR055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_773 4358-1457 8.89 44.6 µM 1.28E-18 3 3.04E-19
2 SGTC_2022 5136654 6.15 200.0 µM 7.29E-10 8 3.80E-10
3 SGTC_1950 st077106 4.56 7.2 µM 3.62E-6 RNA processing & uracil transport 15 2.59E-6
4 SGTC_1939 st074455 4.30 53.6 µM 1.14E-5 23 8.48E-6
5 SGTC_1637 st007924 4.24 17.4 µM 1.49E-5 16 1.12E-5
6 SGTC_834 0312-0008 4.01 75.7 µM 3.94E-5 NEO1 33 3.07E-5
7 SGTC_2018 5133068 3.86 143.0 µM 7.26E-5 25 5.78E-5
8 SGTC_2164 5685496 3.77 200.0 µM 1.03E-4 27 8.27E-5
9 SGTC_1899 st063254 3.71 59.6 µM 1.25E-4 19 1.02E-4
10 SGTC_1945 st075991 3.55 56.6 µM 2.33E-4 60S ribosome export 32 1.93E-4
11 SGTC_861 0443-0273 3.47 110.0 µM 3.14E-4 22 2.63E-4
12 SGTC_138 0850-0259 3.46 40.9 µM 3.25E-4 cell wall 227 2.73E-4
13 SGTC_41 0478-0632 3.45 82.6 µM 3.39E-4 47 2.85E-4
14 SGTC_145 3737-0113 3.42 38.4 µM 3.67E-4 DNA intercalators 100 3.09E-4
15 SGTC_446 go6976 3.39 132.0 µM 4.07E-4 29 3.44E-4
16 SGTC_918 glabranin 3.32 770.7 nM 5.36E-4 59 4.57E-4
17 SGTC_372 0155-0182 3.29 15.9 µM 5.91E-4 mitochondrial response to ROS 51 5.05E-4
18 SGTC_1318 1280-3875 3.28 124.0 µM 6.12E-4 53 5.24E-4
19 SGTC_2360 9040895 3.19 200.0 µM 8.12E-4 RPP1 & pyrimidine depletion 38 7.02E-4
20 SGTC_2428 5615643 3.13 7.8 µM 9.95E-4 58 8.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 1.30E-29 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.141 3.96E-16 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.137 1.78E-15 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.126 3.43E-13 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.125 4.51E-13 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.124 5.99E-13 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.119 5.79E-12 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.113 5.55E-11 YOL057W YOL057W hom Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
0.111 1.07E-10 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.111 1.43E-10 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.108 3.79E-10 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.106 7.88E-10 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.102 3.79E-9 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.098 1.54E-8 YOR138C RUP1 hom Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress
0.097 2.10E-8 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation