YDR056C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR056C / YDR056C

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:-3.15|P-value:5.87E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:6.55|P-value:7.03E-12 ID:SGTC_188|Compound:3229-0966|FD-Score:3.51|P-value:1.41E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.15|P-value:5.67E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.13|P-value:6.18E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.22|P-value:4.31E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.71|P-value:6.47E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.91|P-value:2.64E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.35|P-value:2.80E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.25|P-value:3.94E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.16|P-value:8.55E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.01|P-value:9.79E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.76|P-value:4.75E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.84|P-value:3.60E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.33|P-value:3.07E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.02|P-value:9.11E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.86|P-value:2.53E-7 ID:SGTC_1581|Compound:himbacine|FD-Score:3.09|P-value:7.08E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.01|P-value:9.85E-4 ID:SGTC_1795|Compound:st049545|FD-Score:4.32|P-value:4.08E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-3.55|P-value:1.28E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-5.64|P-value:3.16E-9 ID:SGTC_1988|Compound:st071872|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.02|P-value:9.09E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.08|P-value:7.58E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.43|P-value:2.10E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.04|P-value:1.60E-5 ID:SGTC_2175|Compound:5807670|FD-Score:6.50|P-value:1.01E-11 ID:SGTC_2179|Compound:6298986|FD-Score:4.52|P-value:1.52E-6 ID:SGTC_2185|Compound:6113692|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.43|P-value:2.06E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.57|P-value:1.21E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.26|P-value:3.82E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.09|P-value:7.15E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.31|P-value:3.23E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.07|P-value:7.98E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-8.49|P-value:1.04E-18 ID:SGTC_2835|Compound:9006588|FD-Score:8.34|P-value:3.66E-18 ID:SGTC_2855|Compound:9016525|FD-Score:-3.00|P-value:9.98E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.09|P-value:7.30E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.77|P-value:5.24E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.29|P-value:3.43E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.47|P-value:1.78E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.45|P-value:1.84E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:-3.15|P-value:5.87E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:6.55|P-value:7.03E-12 ID:SGTC_188|Compound:3229-0966|FD-Score:3.51|P-value:1.41E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.15|P-value:5.67E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.13|P-value:6.18E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.22|P-value:4.31E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.71|P-value:6.47E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.55|P-value:1.21E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.91|P-value:2.64E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.35|P-value:2.80E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.25|P-value:3.94E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.16|P-value:8.55E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.01|P-value:9.79E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.76|P-value:4.75E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.84|P-value:3.60E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.33|P-value:3.07E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.02|P-value:9.11E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.86|P-value:2.53E-7 ID:SGTC_1581|Compound:himbacine|FD-Score:3.09|P-value:7.08E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.01|P-value:9.85E-4 ID:SGTC_1795|Compound:st049545|FD-Score:4.32|P-value:4.08E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-3.55|P-value:1.28E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-5.64|P-value:3.16E-9 ID:SGTC_1988|Compound:st071872|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.02|P-value:9.09E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.08|P-value:7.58E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.43|P-value:2.10E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.04|P-value:1.60E-5 ID:SGTC_2175|Compound:5807670|FD-Score:6.50|P-value:1.01E-11 ID:SGTC_2179|Compound:6298986|FD-Score:4.52|P-value:1.52E-6 ID:SGTC_2185|Compound:6113692|FD-Score:3.52|P-value:1.36E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.43|P-value:2.06E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.57|P-value:1.21E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.26|P-value:3.82E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.09|P-value:7.15E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.31|P-value:3.23E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.07|P-value:7.98E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-8.49|P-value:1.04E-18 ID:SGTC_2835|Compound:9006588|FD-Score:8.34|P-value:3.66E-18 ID:SGTC_2855|Compound:9016525|FD-Score:-3.00|P-value:9.98E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.09|P-value:7.30E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.77|P-value:5.24E-5 ID:SGTC_3024|Compound:9090631|FD-Score:3.29|P-value:3.43E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.47|P-value:1.78E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.45|P-value:1.84E-4

Top fitness defect scores for YDR056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2835 9006588 8.34 71.4 µM 3.66E-18 1 3.64E-17
2 SGTC_65 0798-0905 6.55 35.0 µM 7.03E-12 calcium & mitochondrial duress 22 2.96E-11
3 SGTC_2175 5807670 6.50 165.3 µM 1.01E-11 7 4.15E-11
4 SGTC_1413 3910-0535 4.86 34.4 µM 2.53E-7 3 5.72E-7
5 SGTC_2179 6298986 4.52 200.0 µM 1.52E-6 heme requiring 12 3.10E-6
6 SGTC_1795 st049545 4.32 62.3 µM 4.08E-6 TSC3-RPN4 9 7.83E-6
7 SGTC_967 1306-0166 4.16 352.0 µM 8.55E-6 27 1.57E-5
8 SGTC_651 3253-0966 3.91 34.4 µM 2.64E-5 calcium & mitochondrial duress 35 4.54E-5
9 SGTC_1153 4055-0057 3.84 267.0 µM 3.60E-5 29 6.09E-5
10 SGTC_648 0375-0473 3.71 33.3 µM 6.47E-5 22 1.06E-4
11 SGTC_650 1328-0195 3.55 38.0 µM 1.21E-4 29 1.90E-4
12 SGTC_2296 7971656 3.54 126.5 µM 1.26E-4 56 1.98E-4
13 SGTC_2185 6113692 3.52 200.0 µM 1.36E-4 ergosterol biosynthesis 27 2.13E-4
14 SGTC_188 3229-0966 3.51 278.5 µM 1.41E-4 41 2.20E-4
15 SGTC_3338 9144300 3.45 39.6 µM 1.84E-4 Golgi 39 2.83E-4
16 SGTC_3024 9090631 3.29 49.5 µM 3.43E-4 17 5.09E-4
17 SGTC_1988 st071872 3.26 53.4 µM 3.71E-4 25 5.48E-4
18 SGTC_2318 6029776 3.26 164.0 µM 3.82E-4 60 5.64E-4
19 SGTC_917 harmaline 3.25 728.1 nM 3.94E-4 ergosterol biosynthesis 53 5.79E-4
20 SGTC_632 0781-2353 3.22 4.7 µM 4.31E-4 Golgi 76 6.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 5.00E-44 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.190 9.86E-29 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.186 1.57E-27 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.179 1.71E-25 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.164 1.04E-21 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.162 4.79E-21 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.159 1.74E-20 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.153 4.09E-19 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.153 4.34E-19 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.153 6.19E-19 YNR025C_d YNR025C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase
0.146 1.94E-17 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.146 2.37E-17 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.145 3.28E-17 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.142 1.84E-16 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.141 2.95E-16 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism