YDR067C_p / OCA6

Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR067C / OCA6

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.74|P-value:6.26E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:5.54|P-value:1.58E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:3.79|P-value:2.38E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.62|P-value:4.90E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.66|P-value:7.83E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.54|P-value:1.40E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:6.10|P-value:8.83E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:4.45|P-value:2.03E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:5.12|P-value:1.18E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:3.59|P-value:4.66E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.38|P-value:8.35E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.76|P-value:2.39E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.63|P-value:3.80E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.66|P-value:3.75E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.36|P-value:9.16E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.29|P-value:5.38E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.32|P-value:3.37E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.54|P-value:5.04E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-5.51|P-value:1.58E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.10|P-value:7.90E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.91|P-value:1.56E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.39|P-value:8.91E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.58|P-value:1.07E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.31|P-value:3.18E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.40|P-value:8.58E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.81|P-value:4.61E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.81|P-value:2.22E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.55|P-value:5.27E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.52|P-value:5.46E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.03|P-value:1.01E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.48|P-value:6.71E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.46|P-value:6.54E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.42|P-value:2.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.46|P-value:1.97E-5 ID:SGTC_2248|Compound:tofa|FD-Score:-3.42|P-value:7.57E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.87|P-value:1.63E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.91|P-value:1.40E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.69|P-value:7.57E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.63|P-value:4.05E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-5.75|P-value:4.98E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.36|P-value:9.71E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.05|P-value:9.32E-5 ID:SGTC_2788|Compound:5282734|FD-Score:-3.81|P-value:2.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:5.91|P-value:2.43E-8 ID:SGTC_2887|Compound:9044784|FD-Score:4.39|P-value:2.54E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.63|P-value:3.70E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.09|P-value:8.23E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.31|P-value:3.55E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.90|P-value:1.61E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.92|P-value:1.54E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.70|P-value:3.00E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.37|P-value:8.72E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.88|P-value:1.72E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.08|P-value:3.06E-11 ID:SGTC_3322|Compound:9139058|FD-Score:3.49|P-value:6.60E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.51|P-value:5.62E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.81|P-value:2.21E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.74|P-value:6.26E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:5.54|P-value:1.58E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:3.79|P-value:2.38E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.62|P-value:4.90E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.66|P-value:7.83E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.54|P-value:1.40E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:6.10|P-value:8.83E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:4.45|P-value:2.03E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:5.12|P-value:1.18E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:3.59|P-value:4.66E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.38|P-value:8.35E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.76|P-value:2.39E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.63|P-value:3.80E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.66|P-value:3.75E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.36|P-value:9.16E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.29|P-value:5.38E-7 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.32|P-value:3.37E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.54|P-value:5.04E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-5.51|P-value:1.58E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.10|P-value:7.90E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.91|P-value:1.56E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.39|P-value:8.91E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.58|P-value:1.07E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.31|P-value:3.18E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.40|P-value:8.58E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.81|P-value:4.61E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.81|P-value:2.22E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.55|P-value:5.27E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.52|P-value:5.46E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.03|P-value:1.01E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.48|P-value:6.71E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.46|P-value:6.54E-4 ID:SGTC_1903|Compound:st060211|FD-Score:4.42|P-value:2.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.46|P-value:1.97E-5 ID:SGTC_2248|Compound:tofa|FD-Score:-3.42|P-value:7.57E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.87|P-value:1.63E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.91|P-value:1.40E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.69|P-value:7.57E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.63|P-value:4.05E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-5.75|P-value:4.98E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.36|P-value:9.71E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.05|P-value:9.32E-5 ID:SGTC_2788|Compound:5282734|FD-Score:-3.81|P-value:2.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:5.91|P-value:2.43E-8 ID:SGTC_2887|Compound:9044784|FD-Score:4.39|P-value:2.54E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.63|P-value:3.70E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.09|P-value:8.23E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.31|P-value:3.55E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.90|P-value:1.61E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.92|P-value:1.54E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.70|P-value:3.00E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.37|P-value:8.72E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.88|P-value:1.72E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.08|P-value:3.06E-11 ID:SGTC_3322|Compound:9139058|FD-Score:3.49|P-value:6.60E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.51|P-value:5.62E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.81|P-value:2.21E-4

Top fitness defect scores for YDR067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3321 9137793 7.08 26.8 µM 3.06E-11 cell wall 21 6.98E-13
2 SGTC_46 0329-0187a 6.62 2.2 µM 4.90E-10 23 1.78E-11
3 SGTC_129 0088-0017 6.10 176.6 µM 8.83E-9 29 5.18E-10
4 SGTC_2880 9042983 5.91 58.4 µM 2.43E-8 fatty acid desaturase (OLE1) 7 1.69E-9
5 SGTC_18 0111-0177 5.54 500.0 nM 1.58E-7 25 1.50E-8
6 SGTC_1050 3232-1156 5.29 69.3 µM 5.38E-7 RSC complex & mRNA processing 6 6.25E-8
7 SGTC_161 4065-0411 5.12 162.2 µM 1.18E-6 37 1.55E-7
8 SGTC_1457 k015-0032 4.81 57.3 µM 4.61E-6 18 7.64E-7
9 SGTC_8 0354-0001 4.74 70.0 µM 6.26E-6 50 1.09E-6
10 SGTC_2640 pentamidine 4.69 10.4 µM 7.57E-6 mitochondrial processes 16 1.36E-6
11 SGTC_87 0100-0052 4.54 35.5 µM 1.40E-5 74 2.78E-6
12 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.46 70.1 µM 1.97E-5 13 4.13E-6
13 SGTC_159 3970-0959 4.45 50.0 µM 2.03E-5 56 4.28E-6
14 SGTC_1903 st060211 4.42 78.3 µM 2.30E-5 13 4.96E-6
15 SGTC_2887 9044784 4.39 58.4 µM 2.54E-5 fatty acid desaturase (OLE1) 21 5.57E-6
16 SGTC_1053 3366-3204 4.32 134.0 µM 3.37E-5 cell wall 27 7.73E-6
17 SGTC_3137 9097352 4.31 49.5 µM 3.55E-5 35 8.22E-6
18 SGTC_1226 3909-7979 4.10 35.4 µM 7.90E-5 35 2.08E-5
19 SGTC_2896 9052656 4.09 71.4 µM 8.23E-5 endomembrane recycling 106 2.18E-5
20 SGTC_2781 5567276 4.05 71.4 µM 9.32E-5 43 2.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 1.37E-46 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.193 1.42E-29 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.183 1.12E-26 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.178 2.08E-25 YHL029C_p OCA5_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.162 4.39E-21 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.157 6.23E-20 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.148 6.22E-18 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.145 2.85E-17 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.133 1.22E-14 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.127 1.36E-13 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.127 1.89E-13 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.47E-12 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.119 4.89E-12 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.119 5.47E-12 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.115 2.09E-11 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface