YDR070C / FMP16

Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR070C / FMP16

Click on Significant Values for Screen Details

Top fitness defect scores for YDR070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1776 st049249 5.55 45.9 µM 1.34E-9 3 1.47E-8
2 SGTC_2012 4023501 5.17 200.0 µM 1.42E-8 9 1.15E-7
3 SGTC_1103 duloxetine 5.16 36.1 µM 1.55E-8 7 1.24E-7
4 SGTC_392 N-ethylmaleimide 4.50 8.3 µM 7.09E-7 RNA pol III & RNase P/MRP 7 3.48E-6
5 SGTC_3194 9111903 4.26 49.5 µM 2.42E-6 17 1.02E-5
6 SGTC_573 3702-0553 4.17 84.7 µM 3.81E-6 11 1.51E-5
7 SGTC_2756 carbadox 4.03 75.1 µM 7.76E-6 56 2.81E-5
8 SGTC_2398 5228213 3.99 48.8 µM 9.28E-6 iron homeostasis 38 3.29E-5
9 SGTC_1164 k060-0068 3.98 93.7 µM 9.95E-6 23 3.50E-5
10 SGTC_2917 7979103 3.87 53.8 µM 1.62E-5 32 5.34E-5
11 SGTC_3216 9129716 3.87 49.5 µM 1.68E-5 RPP1 & pyrimidine depletion 26 5.52E-5
12 SGTC_2964 9083345 3.81 53.4 µM 2.14E-5 21 6.83E-5
13 SGTC_159 3970-0959 3.79 50.0 µM 2.39E-5 82 7.52E-5
14 SGTC_2552 juarezic acid 3.74 87.0 µM 3.04E-5 TSC3-RPN4 45 9.29E-5
15 SGTC_2134 5324836 3.71 1.5 µM 3.40E-5 20 1.02E-4
16 SGTC_1099 5-nonyloxytryptamine 3.60 2.9 µM 5.52E-5 28 1.57E-4
17 SGTC_2001 4023502 3.56 57.7 µM 6.66E-5 mitochondrial processes 31 1.85E-4
18 SGTC_422 cantharidin 3.46 155.0 µM 1.04E-4 cell wall signaling 76 2.73E-4
19 SGTC_3214 9129694 3.37 49.5 µM 1.52E-4 45 3.80E-4
20 SGTC_727 3032-0951 3.36 202.0 µM 1.56E-4 44 3.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.16E-9 YMR066W SOV1 hom Mitochondrial protein of unknown function
0.094 4.30E-8 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.091 1.13E-7 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.086 6.37E-7 YOR221C MCT1 hom Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
0.084 1.07E-6 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.084 1.25E-6 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form
0.082 1.79E-6 YJR096W YJR096W hom Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.082 2.11E-6 YDR316W OMS1 hom Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
0.080 3.66E-6 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.080 3.92E-6 YDR489W SLD5 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.079 4.87E-6 YLR459W GAB1 het GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
0.077 7.51E-6 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.077 9.22E-6 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.076 9.41E-6 YML012W ERV25 hom Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
0.075 1.20E-5 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane