YDR080W / VPS41

Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR080W / VPS41

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.91|P-value:5.85E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.14|P-value:9.78E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.34|P-value:7.02E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:7.79|P-value:8.09E-15 ID:SGTC_143|Compound:4032-1194|FD-Score:4.23|P-value:1.53E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:6.64|P-value:3.01E-11 ID:SGTC_214|Compound:4373-3496|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_232|Compound:clozapine|FD-Score:4.62|P-value:2.56E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:6.59|P-value:4.23E-11 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.78|P-value:1.01E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.82|P-value:8.34E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.84|P-value:7.60E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.74|P-value:1.49E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.30|P-value:5.76E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:30.10|P-value:2.92E-193 ID:SGTC_431|Compound:k089-0097|FD-Score:5.98|P-value:1.90E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.75|P-value:1.41E-6 ID:SGTC_447|Compound:ml7|FD-Score:5.84|P-value:4.35E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:8.38|P-value:7.10E-17 ID:SGTC_459|Compound:nigericin|FD-Score:16.10|P-value:8.28E-57 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.07|P-value:3.00E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.15|P-value:9.69E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.77|P-value:1.02E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:15.50|P-value:6.76E-53 ID:SGTC_562|Compound:3772-2733|FD-Score:4.55|P-value:3.66E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:4.95|P-value:5.40E-7 ID:SGTC_619|Compound:1652-1634|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.51|P-value:2.77E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.27|P-value:1.30E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:6.92|P-value:4.69E-12 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.18|P-value:8.96E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.91|P-value:5.80E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-5.12|P-value:2.39E-7 ID:SGTC_772|Compound:k072-0172|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:4.48|P-value:4.92E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:5.77|P-value:6.59E-9 ID:SGTC_824|Compound:1304-0008|FD-Score:5.07|P-value:2.90E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:11.80|P-value:2.43E-31 ID:SGTC_879|Compound:0831-1030|FD-Score:3.25|P-value:6.70E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.04|P-value:1.95E-12 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.40|P-value:4.14E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.80|P-value:8.89E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.04|P-value:3.36E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.79|P-value:9.40E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.45|P-value:3.93E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.05|P-value:3.18E-7 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.80|P-value:9.28E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.25|P-value:6.77E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.10|P-value:1.38E-23 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.47|P-value:3.26E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.98|P-value:4.31E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.96|P-value:3.53E-12 ID:SGTC_1660|Compound:st012960|FD-Score:5.42|P-value:4.54E-8 ID:SGTC_1687|Compound:st020778|FD-Score:17.00|P-value:3.04E-63 ID:SGTC_1731|Compound:st035964|FD-Score:3.16|P-value:9.08E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.64|P-value:1.75E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.64|P-value:1.36E-8 ID:SGTC_1801|Compound:st050089|FD-Score:3.48|P-value:3.04E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.45|P-value:5.67E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.98|P-value:3.00E-12 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.76|P-value:1.34E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.20|P-value:6.17E-24 ID:SGTC_1884|Compound:5633444|FD-Score:4.10|P-value:2.60E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.25|P-value:6.88E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.30|P-value:5.86E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.36|P-value:4.54E-4 ID:SGTC_2029|Compound:5175081|FD-Score:5.26|P-value:1.05E-7 ID:SGTC_2077|Compound:5212015|FD-Score:5.13|P-value:2.12E-7 ID:SGTC_2090|Compound:5301565|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.32|P-value:5.52E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.59|P-value:2.03E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.35|P-value:4.75E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.41|P-value:3.99E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.95|P-value:2.22E-9 ID:SGTC_2300|Compound:7976697|FD-Score:3.81|P-value:8.48E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.30|P-value:5.74E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.98|P-value:4.37E-5 ID:SGTC_2389|Compound:9091542|FD-Score:5.60|P-value:1.67E-8 ID:SGTC_2459|Compound:5811157|FD-Score:3.90|P-value:5.91E-5 ID:SGTC_2475|Compound:5812728|FD-Score:4.48|P-value:4.94E-6 ID:SGTC_2481|Compound:5478948|FD-Score:6.03|P-value:1.36E-9 ID:SGTC_2482|Compound:5981709|FD-Score:5.26|P-value:1.06E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:27.30|P-value:1.71E-159 ID:SGTC_2516|Compound:gossypol|FD-Score:8.16|P-value:4.29E-16 ID:SGTC_2521|Compound:angolensin|FD-Score:4.93|P-value:5.76E-7 ID:SGTC_2526|Compound:patulin|FD-Score:8.71|P-value:4.79E-18 ID:SGTC_2555|Compound:cholic acid|FD-Score:-4.51|P-value:4.52E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:4.25|P-value:1.41E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.81|P-value:1.04E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.40|P-value:3.97E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.21|P-value:4.68E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.25|P-value:1.48E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.33|P-value:5.16E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:7.00|P-value:2.67E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.13|P-value:5.44E-16 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.33|P-value:7.60E-8 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.96|P-value:4.99E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.41|P-value:6.74E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.43|P-value:3.76E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.23|P-value:7.57E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:6.57|P-value:4.75E-11 ID:SGTC_2829|Compound:7992743|FD-Score:4.18|P-value:1.84E-5 ID:SGTC_2830|Compound:7992007|FD-Score:5.43|P-value:4.39E-8 ID:SGTC_2930|Compound:9013230|FD-Score:3.51|P-value:2.68E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.82|P-value:1.09E-6 ID:SGTC_2967|Compound:9089538|FD-Score:-6.20|P-value:5.14E-10 ID:SGTC_2973|Compound:9094665|FD-Score:-9.42|P-value:8.79E-21 ID:SGTC_2987|Compound:9018338|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_2991|Compound:9074669|FD-Score:10.80|P-value:1.01E-26 ID:SGTC_3133|Compound:9127736|FD-Score:-3.79|P-value:9.85E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.25|P-value:7.00E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.91|P-value:5.85E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.14|P-value:9.78E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.34|P-value:7.02E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:7.79|P-value:8.09E-15 ID:SGTC_143|Compound:4032-1194|FD-Score:4.23|P-value:1.53E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:6.64|P-value:3.01E-11 ID:SGTC_214|Compound:4373-3496|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_232|Compound:clozapine|FD-Score:4.62|P-value:2.56E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:6.59|P-value:4.23E-11 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.78|P-value:1.01E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.82|P-value:8.34E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.84|P-value:7.60E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.74|P-value:1.49E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.30|P-value:5.76E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:30.10|P-value:2.92E-193 ID:SGTC_431|Compound:k089-0097|FD-Score:5.98|P-value:1.90E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.75|P-value:1.41E-6 ID:SGTC_447|Compound:ml7|FD-Score:5.84|P-value:4.35E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:8.38|P-value:7.10E-17 ID:SGTC_459|Compound:nigericin|FD-Score:16.10|P-value:8.28E-57 ID:SGTC_466|Compound:geldanamycin|FD-Score:4.07|P-value:3.00E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.15|P-value:9.69E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.77|P-value:1.02E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.21|P-value:7.62E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:15.50|P-value:6.76E-53 ID:SGTC_562|Compound:3772-2733|FD-Score:4.55|P-value:3.66E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:4.95|P-value:5.40E-7 ID:SGTC_619|Compound:1652-1634|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.51|P-value:2.77E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.27|P-value:1.30E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:6.92|P-value:4.69E-12 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.18|P-value:8.96E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.91|P-value:5.80E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-5.12|P-value:2.39E-7 ID:SGTC_772|Compound:k072-0172|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:4.48|P-value:4.92E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:5.77|P-value:6.59E-9 ID:SGTC_824|Compound:1304-0008|FD-Score:5.07|P-value:2.90E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:11.80|P-value:2.43E-31 ID:SGTC_879|Compound:0831-1030|FD-Score:3.25|P-value:6.70E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.04|P-value:1.95E-12 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.40|P-value:4.14E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.80|P-value:8.89E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.04|P-value:3.36E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.79|P-value:9.40E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.45|P-value:3.93E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.05|P-value:3.18E-7 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.80|P-value:9.28E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.25|P-value:6.77E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.10|P-value:1.38E-23 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.47|P-value:3.26E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.98|P-value:4.31E-5 ID:SGTC_1658|Compound:st012944|FD-Score:6.96|P-value:3.53E-12 ID:SGTC_1660|Compound:st012960|FD-Score:5.42|P-value:4.54E-8 ID:SGTC_1687|Compound:st020778|FD-Score:17.00|P-value:3.04E-63 ID:SGTC_1731|Compound:st035964|FD-Score:3.16|P-value:9.08E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.64|P-value:1.75E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.64|P-value:1.36E-8 ID:SGTC_1801|Compound:st050089|FD-Score:3.48|P-value:3.04E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.45|P-value:5.67E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.98|P-value:3.00E-12 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.76|P-value:1.34E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.20|P-value:6.17E-24 ID:SGTC_1884|Compound:5633444|FD-Score:4.10|P-value:2.60E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.25|P-value:6.88E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.30|P-value:5.86E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.36|P-value:4.54E-4 ID:SGTC_2029|Compound:5175081|FD-Score:5.26|P-value:1.05E-7 ID:SGTC_2077|Compound:5212015|FD-Score:5.13|P-value:2.12E-7 ID:SGTC_2090|Compound:5301565|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.32|P-value:5.52E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.59|P-value:2.03E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.35|P-value:4.75E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.41|P-value:3.99E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.95|P-value:2.22E-9 ID:SGTC_2300|Compound:7976697|FD-Score:3.81|P-value:8.48E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.30|P-value:5.74E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.98|P-value:4.37E-5 ID:SGTC_2389|Compound:9091542|FD-Score:5.60|P-value:1.67E-8 ID:SGTC_2459|Compound:5811157|FD-Score:3.90|P-value:5.91E-5 ID:SGTC_2475|Compound:5812728|FD-Score:4.48|P-value:4.94E-6 ID:SGTC_2481|Compound:5478948|FD-Score:6.03|P-value:1.36E-9 ID:SGTC_2482|Compound:5981709|FD-Score:5.26|P-value:1.06E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:27.30|P-value:1.71E-159 ID:SGTC_2516|Compound:gossypol|FD-Score:8.16|P-value:4.29E-16 ID:SGTC_2521|Compound:angolensin|FD-Score:4.93|P-value:5.76E-7 ID:SGTC_2526|Compound:patulin|FD-Score:8.71|P-value:4.79E-18 ID:SGTC_2555|Compound:cholic acid|FD-Score:-4.51|P-value:4.52E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:4.25|P-value:1.41E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.81|P-value:1.04E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.40|P-value:3.97E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.21|P-value:4.68E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.25|P-value:1.48E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.33|P-value:5.16E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:7.00|P-value:2.67E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.13|P-value:5.44E-16 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.33|P-value:7.60E-8 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.96|P-value:4.99E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.41|P-value:6.74E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.43|P-value:3.76E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.23|P-value:7.57E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:6.57|P-value:4.75E-11 ID:SGTC_2829|Compound:7992743|FD-Score:4.18|P-value:1.84E-5 ID:SGTC_2830|Compound:7992007|FD-Score:5.43|P-value:4.39E-8 ID:SGTC_2930|Compound:9013230|FD-Score:3.51|P-value:2.68E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-4.82|P-value:1.09E-6 ID:SGTC_2967|Compound:9089538|FD-Score:-6.20|P-value:5.14E-10 ID:SGTC_2973|Compound:9094665|FD-Score:-9.42|P-value:8.79E-21 ID:SGTC_2987|Compound:9018338|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_2991|Compound:9074669|FD-Score:10.80|P-value:1.01E-26 ID:SGTC_3133|Compound:9127736|FD-Score:-3.79|P-value:9.85E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.66|P-value:1.52E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.25|P-value:7.00E-4

Top fitness defect scores for YDR080W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_391 gliotoxin 30.10 8.3 µM 2.92E-193 1 4.04E-199
2 SGTC_2514 salinomycin 27.30 42.7 µM 1.71E-159 1 2.60E-164
3 SGTC_1687 st020778 17.00 55.4 µM 3.04E-63 14 4.21E-65
4 SGTC_459 nigericin 16.10 15.3 µM 8.28E-57 1 1.81E-58
5 SGTC_528 3492-0019 15.50 172.0 µM 6.76E-53 calcium & mitochondrial duress 13 1.94E-54
6 SGTC_841 0251-0215 11.80 91.2 µM 2.43E-31 8 3.18E-32
7 SGTC_2991 9074669 10.80 71.4 µM 1.01E-26 azole & statin 5 1.82E-27
8 SGTC_1877 wortmannin 10.20 25.0 µM 6.17E-24 14 1.35E-24
9 SGTC_1495 4469-0029 10.10 237.0 µM 1.38E-23 16 3.10E-24
10 SGTC_2526 patulin 8.71 37.6 µM 4.79E-18 12 1.58E-18
11 SGTC_457 grayanotoxin iii 8.38 135.0 µM 7.10E-17 9 2.54E-17
12 SGTC_2516 gossypol 8.16 71.5 µM 4.29E-16 3 1.62E-16
13 SGTC_2679 rapamycin 8.13 1.0 nM 5.44E-16 40 2.07E-16
14 SGTC_123 0083-0120 7.79 66.7 µM 8.09E-15 10 3.33E-15
15 SGTC_908 3448-7491 7.04 47.7 µM 1.95E-12 mitochondrial stress 26 9.46E-13
16 SGTC_2675 theaflavin digallate 7.00 100.0 µM 2.67E-12 iron homeostasis 9 1.31E-12
17 SGTC_1844 rapamycin 6.98 4.0 nM 3.00E-12 72 1.47E-12
18 SGTC_1658 st012944 6.96 20.0 µM 3.53E-12 iron homeostasis 18 1.74E-12
19 SGTC_722 3534-0461 6.92 190.0 µM 4.69E-12 PDR1 4 2.34E-12
20 SGTC_1873 rapamycin 6.76 2.0 nM 1.34E-11 22 6.90E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.655 0 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.623 0 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.543 5.70E-256 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.392 9.42E-124 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.384 2.80E-118 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.378 2.31E-114 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.371 4.98E-110 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.364 1.68E-105 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.361 7.92E-104 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.358 5.22E-102 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.347 2.16E-95 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.344 1.16E-93 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.300 5.83E-71 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.296 5.65E-69 YGL124C MON1 hom Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
0.289 2.17E-65 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules