YDR084C / TVP23

Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR084C / TVP23

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:13.40|P-value:7.40E-46 ID:SGTC_146|Compound:3448-8650|FD-Score:3.63|P-value:4.73E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.07|P-value:6.19E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:3.16|P-value:3.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.10|P-value:5.53E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:3.76|P-value:2.63E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.75|P-value:4.20E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:2.99|P-value:6.23E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.54|P-value:1.24E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.39|P-value:1.30E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:6.55|P-value:1.38E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:16.70|P-value:2.77E-70 ID:SGTC_806|Compound:3966-4455|FD-Score:4.97|P-value:5.32E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:5.58|P-value:1.27E-9 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.68|P-value:6.80E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.14|P-value:5.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.56|P-value:1.10E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.16|P-value:4.12E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:8.05|P-value:5.32E-18 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.88|P-value:1.54E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.43|P-value:1.98E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.29|P-value:1.95E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.77|P-value:2.53E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.51|P-value:8.11E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.76|P-value:4.79E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.87|P-value:9.60E-8 ID:SGTC_1547|Compound:harmine|FD-Score:3.52|P-value:7.64E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:6.18|P-value:2.22E-11 ID:SGTC_1581|Compound:himbacine|FD-Score:3.10|P-value:4.24E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.55|P-value:4.75E-20 ID:SGTC_1712|Compound:st032288|FD-Score:4.90|P-value:7.81E-8 ID:SGTC_1713|Compound:st033146|FD-Score:-4.15|P-value:8.23E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-3.09|P-value:6.91E-4 ID:SGTC_1754|Compound:st042065|FD-Score:18.90|P-value:9.97E-90 ID:SGTC_1760|Compound:st045453|FD-Score:16.50|P-value:1.26E-68 ID:SGTC_1797|Compound:st048695|FD-Score:3.26|P-value:2.25E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.10|P-value:3.74E-11 ID:SGTC_1801|Compound:st050089|FD-Score:9.07|P-value:2.57E-22 ID:SGTC_1803|Compound:st050068|FD-Score:8.36|P-value:2.81E-19 ID:SGTC_1804|Compound:st050076|FD-Score:4.20|P-value:3.42E-6 ID:SGTC_1805|Compound:st050013|FD-Score:2.98|P-value:6.51E-4 ID:SGTC_1809|Compound:st050081|FD-Score:2.97|P-value:6.72E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.00|P-value:6.00E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.86|P-value:1.73E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.77|P-value:4.53E-5 ID:SGTC_2006|Compound:4011487|FD-Score:23.80|P-value:3.67E-140 ID:SGTC_2015|Compound:5119600|FD-Score:-4.34|P-value:3.23E-6 ID:SGTC_2021|Compound:4019055|FD-Score:8.89|P-value:1.62E-21 ID:SGTC_2036|Compound:5160441|FD-Score:4.29|P-value:2.10E-6 ID:SGTC_2049|Compound:5262831|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_2152|Compound:5568786|FD-Score:2.86|P-value:9.99E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.47|P-value:9.60E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.78|P-value:2.50E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.74|P-value:3.00E-5 ID:SGTC_2277|Compound:7947813|FD-Score:-3.06|P-value:7.86E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.43|P-value:1.11E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.65|P-value:7.68E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.25|P-value:3.79E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.33|P-value:2.82E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.67|P-value:4.03E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.53|P-value:7.34E-5 ID:SGTC_2896|Compound:9052656|FD-Score:8.13|P-value:2.48E-18 ID:SGTC_2940|Compound:9060638|FD-Score:4.28|P-value:2.26E-6 ID:SGTC_3006|Compound:9075424|FD-Score:2.94|P-value:7.51E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.72|P-value:3.16E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.07|P-value:7.65E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.14|P-value:1.43E-14 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.19|P-value:4.77E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.99|P-value:1.69E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.37|P-value:2.41E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.25|P-value:2.62E-6 ID:SGTC_3265|Compound:9137266|FD-Score:-3.00|P-value:9.67E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:13.40|P-value:7.40E-46 ID:SGTC_146|Compound:3448-8650|FD-Score:3.63|P-value:4.73E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.07|P-value:6.19E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:3.16|P-value:3.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.10|P-value:5.53E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:3.76|P-value:2.63E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.75|P-value:4.20E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:2.99|P-value:6.23E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.54|P-value:1.24E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.39|P-value:1.30E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:6.55|P-value:1.38E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:16.70|P-value:2.77E-70 ID:SGTC_806|Compound:3966-4455|FD-Score:4.97|P-value:5.32E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:5.58|P-value:1.27E-9 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.68|P-value:6.80E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.14|P-value:5.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.56|P-value:1.10E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.16|P-value:4.12E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:8.05|P-value:5.32E-18 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.88|P-value:1.54E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.43|P-value:1.98E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.29|P-value:1.95E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.77|P-value:2.53E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.51|P-value:8.11E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.76|P-value:4.79E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.87|P-value:9.60E-8 ID:SGTC_1547|Compound:harmine|FD-Score:3.52|P-value:7.64E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:6.18|P-value:2.22E-11 ID:SGTC_1581|Compound:himbacine|FD-Score:3.10|P-value:4.24E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.55|P-value:4.75E-20 ID:SGTC_1712|Compound:st032288|FD-Score:4.90|P-value:7.81E-8 ID:SGTC_1713|Compound:st033146|FD-Score:-4.15|P-value:8.23E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-3.09|P-value:6.91E-4 ID:SGTC_1754|Compound:st042065|FD-Score:18.90|P-value:9.97E-90 ID:SGTC_1760|Compound:st045453|FD-Score:16.50|P-value:1.26E-68 ID:SGTC_1797|Compound:st048695|FD-Score:3.26|P-value:2.25E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.10|P-value:3.74E-11 ID:SGTC_1801|Compound:st050089|FD-Score:9.07|P-value:2.57E-22 ID:SGTC_1803|Compound:st050068|FD-Score:8.36|P-value:2.81E-19 ID:SGTC_1804|Compound:st050076|FD-Score:4.20|P-value:3.42E-6 ID:SGTC_1805|Compound:st050013|FD-Score:2.98|P-value:6.51E-4 ID:SGTC_1809|Compound:st050081|FD-Score:2.97|P-value:6.72E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.00|P-value:6.00E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.86|P-value:1.73E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.77|P-value:4.53E-5 ID:SGTC_2006|Compound:4011487|FD-Score:23.80|P-value:3.67E-140 ID:SGTC_2015|Compound:5119600|FD-Score:-4.34|P-value:3.23E-6 ID:SGTC_2021|Compound:4019055|FD-Score:8.89|P-value:1.62E-21 ID:SGTC_2036|Compound:5160441|FD-Score:4.29|P-value:2.10E-6 ID:SGTC_2049|Compound:5262831|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_2152|Compound:5568786|FD-Score:2.86|P-value:9.99E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.47|P-value:9.60E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.78|P-value:2.50E-5 ID:SGTC_2267|Compound:7931562|FD-Score:3.74|P-value:3.00E-5 ID:SGTC_2277|Compound:7947813|FD-Score:-3.06|P-value:7.86E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.43|P-value:1.11E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.65|P-value:7.68E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.25|P-value:3.79E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.33|P-value:2.82E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.67|P-value:4.03E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.53|P-value:7.34E-5 ID:SGTC_2896|Compound:9052656|FD-Score:8.13|P-value:2.48E-18 ID:SGTC_2940|Compound:9060638|FD-Score:4.28|P-value:2.26E-6 ID:SGTC_3006|Compound:9075424|FD-Score:2.94|P-value:7.51E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.72|P-value:3.16E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.07|P-value:7.65E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.14|P-value:1.43E-14 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.19|P-value:4.77E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.99|P-value:1.69E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.37|P-value:2.41E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.25|P-value:2.62E-6 ID:SGTC_3265|Compound:9137266|FD-Score:-3.00|P-value:9.67E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.21|P-value:2.68E-4

Top fitness defect scores for YDR084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2006 4011487 23.80 200.0 µM 3.67E-140 endomembrane recycling 3 2.77E-125
2 SGTC_1754 st042065 18.90 16.1 µM 9.97E-90 NEO1-PIK1 3 3.58E-80
3 SGTC_788 1182-0090 16.70 188.0 µM 2.77E-70 endomembrane recycling 5 8.65E-63
4 SGTC_1760 st045453 16.50 10.4 µM 1.26E-68 NEO1-PIK1 11 2.62E-61
5 SGTC_15 0266-0086 13.40 27.1 µM 7.40E-46 endomembrane recycling 2 5.79E-41
6 SGTC_1801 st050089 9.07 28.4 µM 2.57E-22 NEO1-PIK1 17 5.95E-20
7 SGTC_2021 4019055 8.89 173.0 µM 1.62E-21 endomembrane recycling 17 3.07E-19
8 SGTC_1672 st016598 8.55 6.5 µM 4.75E-20 endomembrane recycling 17 6.25E-18
9 SGTC_1803 st050068 8.36 52.4 µM 2.81E-19 NEO1-PIK1 34 3.05E-17
10 SGTC_2896 9052656 8.13 71.4 µM 2.48E-18 endomembrane recycling 17 2.12E-16
11 SGTC_1230 0170-0365 8.05 3.8 µM 5.32E-18 endomembrane recycling 10 4.19E-16
12 SGTC_3037 9091026 7.14 49.5 µM 1.43E-14 NEO1-PIK1 25 4.78E-13
13 SGTC_649 1123-0311 6.55 367.0 µM 1.38E-12 endomembrane recycling 22 2.80E-11
14 SGTC_1573 oleylamine 6.18 1.1 µM 2.22E-11 9 3.31E-10
15 SGTC_1800 st050079 6.10 29.1 µM 3.74E-11 NEO1-PIK1 35 5.26E-10
16 SGTC_313 3474-0040 5.75 5.0 µM 4.20E-10 NEO1-PIK1 27 4.53E-9
17 SGTC_945 3381-0768 5.58 11.3 µM 1.27E-9 endomembrane recycling 10 1.21E-8
18 SGTC_806 3966-4455 4.97 5.9 µM 5.32E-8 7 3.36E-7
19 SGTC_1712 st032288 4.90 53.4 µM 7.81E-8 calcium & mitochondrial duress 123 4.73E-7
20 SGTC_1373 2887-0003 4.87 58.5 µM 9.60E-8 Golgi 7 5.68E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.576 4.26E-295 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.554 1.02E-269 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.474 1.21E-187 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.470 3.04E-183 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.464 5.08E-179 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.451 5.07E-168 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.442 1.61E-160 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.440 1.98E-158 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.415 9.00E-140 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.403 3.66E-131 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.397 7.36E-127 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.396 2.35E-126 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.393 4.11E-124 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.383 6.21E-118 YEL048C TCA17 hom Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
0.383 2.00E-117 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism