YDR088C / SLU7

RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR088C / SLU7

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-5.59|P-value:8.29E-13 ID:SGTC_168|Compound:3970-0862|FD-Score:5.03|P-value:1.86E-10 ID:SGTC_183|Compound:3914-0051|FD-Score:2.72|P-value:3.87E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.15|P-value:4.78E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.90|P-value:1.14E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:2.74|P-value:3.53E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.77|P-value:3.11E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.27|P-value:2.57E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-2.54|P-value:6.07E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.09|P-value:6.40E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:2.53|P-value:9.10E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.85|P-value:1.46E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.58|P-value:5.08E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-2.82|P-value:1.65E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:2.70|P-value:4.20E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.85|P-value:2.16E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.44|P-value:9.17E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.82|P-value:1.67E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.10|P-value:4.08E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.66|P-value:1.76E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.56|P-value:3.12E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.97|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.09|P-value:1.11E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:2.70|P-value:4.31E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.02|P-value:9.31E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.78|P-value:2.07E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.69|P-value:4.45E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.88|P-value:1.87E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:5.71|P-value:5.54E-13 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.53|P-value:6.31E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.67|P-value:4.82E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:2.71|P-value:4.06E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.93|P-value:1.47E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.92|P-value:1.03E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-2.50|P-value:7.16E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.10|P-value:6.22E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.93|P-value:1.45E-4 ID:SGTC_1790|Compound:st045711|FD-Score:2.59|P-value:6.93E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.86|P-value:2.01E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.66|P-value:5.11E-4 ID:SGTC_2012|Compound:4023501|FD-Score:2.80|P-value:2.69E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.94|P-value:9.16E-5 ID:SGTC_2275|Compound:7947463|FD-Score:2.66|P-value:5.12E-4 ID:SGTC_2288|Compound:7946289|FD-Score:2.77|P-value:3.10E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.09|P-value:1.17E-10 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.92|P-value:5.57E-7 ID:SGTC_2421|Compound:5690543|FD-Score:2.85|P-value:2.15E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:2.62|P-value:5.92E-4 ID:SGTC_2804|Compound:7954240|FD-Score:2.70|P-value:4.21E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.03|P-value:5.85E-5 ID:SGTC_3049|Compound:9092223|FD-Score:2.72|P-value:3.85E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.11|P-value:5.74E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.59|P-value:8.29E-13 ID:SGTC_168|Compound:3970-0862|FD-Score:5.03|P-value:1.86E-10 ID:SGTC_183|Compound:3914-0051|FD-Score:2.72|P-value:3.87E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.15|P-value:4.78E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.90|P-value:1.14E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:2.74|P-value:3.53E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.77|P-value:3.11E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.27|P-value:2.57E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-2.54|P-value:6.07E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.09|P-value:6.40E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:2.53|P-value:9.10E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.85|P-value:1.46E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.58|P-value:5.08E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-2.82|P-value:1.65E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:2.70|P-value:4.20E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.85|P-value:2.16E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.44|P-value:9.17E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.82|P-value:1.67E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.10|P-value:4.08E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.66|P-value:1.76E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.56|P-value:3.12E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.97|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.09|P-value:1.11E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:2.70|P-value:4.31E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.02|P-value:9.31E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-2.78|P-value:2.07E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:2.69|P-value:4.45E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.88|P-value:1.87E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:5.71|P-value:5.54E-13 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.53|P-value:6.31E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.67|P-value:4.82E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:2.71|P-value:4.06E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.93|P-value:1.47E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.92|P-value:1.03E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-2.50|P-value:7.16E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.10|P-value:6.22E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.93|P-value:1.45E-4 ID:SGTC_1790|Compound:st045711|FD-Score:2.59|P-value:6.93E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.86|P-value:2.01E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.66|P-value:5.11E-4 ID:SGTC_2012|Compound:4023501|FD-Score:2.80|P-value:2.69E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.94|P-value:9.16E-5 ID:SGTC_2275|Compound:7947463|FD-Score:2.66|P-value:5.12E-4 ID:SGTC_2288|Compound:7946289|FD-Score:2.77|P-value:3.10E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.09|P-value:1.17E-10 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.92|P-value:5.57E-7 ID:SGTC_2421|Compound:5690543|FD-Score:2.85|P-value:2.15E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:2.62|P-value:5.92E-4 ID:SGTC_2804|Compound:7954240|FD-Score:2.70|P-value:4.21E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.03|P-value:5.85E-5 ID:SGTC_3049|Compound:9092223|FD-Score:2.72|P-value:3.85E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.11|P-value:5.74E-5

Top fitness defect scores for YDR088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1382 3002-2117 5.71 298.0 µM 5.54E-13 1 5.55E-9 0.88
2 SGTC_2398 5228213 5.09 48.8 µM 1.17E-10 iron homeostasis 7 1.78E-7 0.08
3 SGTC_168 3970-0862 5.03 530.5 µM 1.86E-10 28 2.40E-7 0.04
4 SGTC_2407 paclitaxel 3.92 400.0 µM 5.57E-7 6 4.38E-5 0.20
5 SGTC_446 go6976 3.27 132.0 µM 2.57E-5 6 5.41E-4 0.01
6 SGTC_189 3970-0742 3.15 2.1 µM 4.78E-5 6 8.17E-4 0.12
7 SGTC_3210 9128157 3.11 49.5 µM 5.74E-5 28 9.21E-4 0.01
8 SGTC_1567 st069303 3.10 68.4 µM 6.22E-5 mitochondrial processes 22 9.72E-4 0.02
9 SGTC_492 tmb-8 3.09 126.0 µM 6.40E-5 7 9.90E-4 0.08
10 SGTC_1184 1269-1718 3.02 139.0 µM 9.31E-5 14 0.00127 0.00
11 SGTC_1000 4048-0884 2.97 8.7 µM 1.18E-4 copper-dependent oxidative stress 17 0.00149 0.01
12 SGTC_1779 st039427 2.93 55.0 µM 1.45E-4 9 0.00170 0.02
13 SGTC_1454 4239-0054 2.93 42.6 µM 1.47E-4 12 0.00171 0.01
14 SGTC_1378 2093-0007 2.88 380.0 nM 1.87E-4 22 0.00201 0.05
15 SGTC_1795 st049545 2.86 62.3 µM 2.01E-4 TSC3-RPN4 6 0.00211 0.24
16 SGTC_2421 5690543 2.85 90.7 µM 2.15E-4 16 0.00221 0.02
17 SGTC_886 0866-0150 2.85 153.0 µM 2.16E-4 17 0.00222 0.08
18 SGTC_2012 4023501 2.80 200.0 µM 2.69E-4 27 0.00257 0.02
19 SGTC_2288 7946289 2.77 167.3 µM 3.10E-4 21 0.00282 0.01
20 SGTC_436 n,n-dimethylsphingosine 2.77 3.3 µM 3.11E-4 18 0.00283 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 2.82E-41 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.222 9.58E-39 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.220 6.63E-38 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.210 1.22E-34 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.200 1.23E-31 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.200 1.98E-31 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.183 9.87E-27 YOR081C TGL5 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate
0.181 3.83E-26 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.175 1.35E-24 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.175 1.57E-24 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.168 9.23E-23 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.167 1.67E-22 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.157 7.21E-20 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.156 9.36E-20 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.155 1.79E-19 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication