YDR094W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR094W / YDR094W

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.68|P-value:1.43E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.74|P-value:9.43E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.80|P-value:7.38E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.37|P-value:6.32E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.94|P-value:3.72E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.58|P-value:9.48E-8 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.37|P-value:6.29E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:2.90|P-value:4.83E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-4.67|P-value:5.43E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.12|P-value:1.40E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:2.72|P-value:9.58E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.87|P-value:5.50E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.87|P-value:5.62E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.86|P-value:5.58E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:-5.26|P-value:1.14E-9 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.37|P-value:6.15E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.76|P-value:8.23E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.02|P-value:2.30E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:2.71|P-value:9.96E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:2.81|P-value:6.86E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:2.73|P-value:9.55E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.36|P-value:3.65E-7 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.27|P-value:9.91E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:2.90|P-value:4.83E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.77|P-value:8.13E-4 ID:SGTC_1663|Compound:st014140|FD-Score:-3.28|P-value:9.53E-5 ID:SGTC_1668|Compound:st014914|FD-Score:-3.34|P-value:7.22E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.04|P-value:2.15E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.47|P-value:3.98E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.76|P-value:8.36E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.01|P-value:3.19E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.18|P-value:1.81E-9 ID:SGTC_2179|Compound:6298986|FD-Score:2.77|P-value:8.15E-4 ID:SGTC_2180|Compound:6301957|FD-Score:2.89|P-value:4.92E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.44|P-value:4.43E-5 ID:SGTC_2311|Compound:7694451|FD-Score:-2.96|P-value:3.80E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.08|P-value:2.30E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.95|P-value:4.02E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.92|P-value:4.46E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.06|P-value:2.52E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.18|P-value:1.48E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.58|P-value:2.34E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.65|P-value:1.65E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-3.17|P-value:1.55E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.42|P-value:1.40E-13 ID:SGTC_2846|Compound:9008642|FD-Score:3.18|P-value:1.50E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.34|P-value:7.42E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.60|P-value:2.07E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.22|P-value:1.21E-4 ID:SGTC_2975|Compound:9084847|FD-Score:2.97|P-value:3.59E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-2.84|P-value:6.30E-4 ID:SGTC_3189|Compound:9110682|FD-Score:2.97|P-value:3.53E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.51|P-value:3.28E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.64|P-value:1.75E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.67|P-value:5.64E-8 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.68|P-value:1.43E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.74|P-value:9.43E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.80|P-value:7.38E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.37|P-value:6.32E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.94|P-value:3.72E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.58|P-value:9.48E-8 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.37|P-value:6.29E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:2.90|P-value:4.83E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-4.67|P-value:5.43E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.12|P-value:1.40E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:2.72|P-value:9.58E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-2.87|P-value:5.50E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.87|P-value:5.62E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.86|P-value:5.58E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:-5.26|P-value:1.14E-9 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.37|P-value:6.15E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.76|P-value:8.23E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.02|P-value:2.30E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:2.71|P-value:9.96E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:2.81|P-value:6.86E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:2.73|P-value:9.55E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.36|P-value:3.65E-7 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.27|P-value:9.91E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:2.90|P-value:4.83E-4 ID:SGTC_1630|Compound:st005209|FD-Score:2.77|P-value:8.13E-4 ID:SGTC_1663|Compound:st014140|FD-Score:-3.28|P-value:9.53E-5 ID:SGTC_1668|Compound:st014914|FD-Score:-3.34|P-value:7.22E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.04|P-value:2.15E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.47|P-value:3.98E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.76|P-value:8.36E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.01|P-value:3.19E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.18|P-value:1.81E-9 ID:SGTC_2179|Compound:6298986|FD-Score:2.77|P-value:8.15E-4 ID:SGTC_2180|Compound:6301957|FD-Score:2.89|P-value:4.92E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.44|P-value:4.43E-5 ID:SGTC_2311|Compound:7694451|FD-Score:-2.96|P-value:3.80E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.08|P-value:2.30E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.95|P-value:4.02E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.92|P-value:4.46E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.06|P-value:2.52E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.18|P-value:1.48E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.58|P-value:2.34E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.65|P-value:1.65E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-3.17|P-value:1.55E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.42|P-value:1.40E-13 ID:SGTC_2846|Compound:9008642|FD-Score:3.18|P-value:1.50E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.34|P-value:7.42E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.60|P-value:2.07E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.22|P-value:1.21E-4 ID:SGTC_2975|Compound:9084847|FD-Score:2.97|P-value:3.59E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-2.84|P-value:6.30E-4 ID:SGTC_3189|Compound:9110682|FD-Score:2.97|P-value:3.53E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.51|P-value:3.28E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.64|P-value:1.75E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.67|P-value:5.64E-8

Top fitness defect scores for YDR094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1876 myriocin 5.18 605.0 nM 1.81E-9 18 1.09E-7
2 SGTC_1170 0310-0127 4.12 64.8 µM 1.40E-6 22 1.93E-5
3 SGTC_1330 1469-0054 4.02 61.8 µM 2.30E-6 iron homeostasis 15 2.85E-5
4 SGTC_1239 0337-0584 3.86 35.4 µM 5.58E-6 unfolded protein response 58 5.69E-5
5 SGTC_2768 sulfasalazine 3.65 50.2 µM 1.65E-5 24 1.33E-4
6 SGTC_2877 9040724 3.60 71.4 µM 2.07E-5 16 1.59E-4
7 SGTC_2272 7805186 3.44 180.0 µM 4.43E-5 cell wall signaling 29 2.88E-4
8 SGTC_1262 0737-0114 3.37 49.6 µM 6.15E-5 46 3.73E-4
9 SGTC_960 1222-0186 3.37 7.7 µM 6.32E-5 56 3.80E-4
10 SGTC_1209 2323-2347 3.24 50.3 µM 1.15E-4 33 6.07E-4
11 SGTC_2974 9094440 3.22 9.7 µM 1.21E-4 ergosterol biosynthesis 79 6.35E-4
12 SGTC_2846 9008642 3.18 19.5 µM 1.50E-4 36 7.49E-4
13 SGTC_2419 paclitaxel 3.08 166.5 µM 2.30E-4 100 0.00105
14 SGTC_2516 gossypol 3.06 71.5 µM 2.52E-4 53 0.00113
15 SGTC_3189 9110682 2.97 49.5 µM 3.53E-4 72 0.00147
16 SGTC_2975 9084847 2.97 53.7 µM 3.59E-4 81 0.00149
17 SGTC_2514 salinomycin 2.92 42.7 µM 4.46E-4 108 0.00176
18 SGTC_1434 4073-0095 2.90 163.0 µM 4.83E-4 46 0.00188
19 SGTC_1157 4092-0394 2.90 27.6 µM 4.83E-4 87 0.00188
20 SGTC_2180 6301957 2.89 200.0 µM 4.92E-4 RSC complex & mRNA processing 31 0.00191

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.252 1.46E-49 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.245 4.77E-47 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.231 8.05E-42 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.210 1.12E-34 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.201 4.92E-32 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.179 2.02E-25 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.178 3.05E-25 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.177 4.28E-25 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.167 2.12E-22 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.165 6.56E-22 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.160 1.13E-20 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.160 1.22E-20 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.158 2.79E-20 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.155 2.12E-19 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine
0.148 7.54E-18 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress