YDR095C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR095C / YDR095C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.57|P-value:2.14E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.30|P-value:5.70E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.25|P-value:1.83E-16 ID:SGTC_521|Compound:r062-0005|FD-Score:3.16|P-value:9.20E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.99|P-value:3.53E-19 ID:SGTC_558|Compound:k064-0027|FD-Score:-4.25|P-value:1.35E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.14|P-value:9.44E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.21|P-value:7.58E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-4.00|P-value:3.76E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.82|P-value:7.81E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:-4.43|P-value:5.95E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.75|P-value:1.03E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.45|P-value:3.24E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.02|P-value:3.69E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:3.90|P-value:6.01E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.43|P-value:5.87E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.95|P-value:5.00E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.76|P-value:6.63E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.81|P-value:8.36E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.23|P-value:1.49E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.46|P-value:5.07E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.36|P-value:8.00E-6 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.42|P-value:6.21E-6 ID:SGTC_1521|Compound:st012942|FD-Score:-3.97|P-value:4.26E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.57|P-value:2.16E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.16|P-value:1.75E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.94|P-value:4.81E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.17|P-value:9.00E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.01|P-value:3.80E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.00|P-value:4.08E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.58|P-value:2.07E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.78|P-value:9.87E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.11|P-value:8.29E-10 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.04|P-value:3.36E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.00|P-value:3.76E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.45|P-value:3.18E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.75|P-value:1.37E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.94|P-value:5.06E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.84|P-value:7.36E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.74|P-value:1.36E-6 ID:SGTC_3291|Compound:9121177|FD-Score:-3.23|P-value:7.05E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.57|P-value:2.14E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.30|P-value:5.70E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.25|P-value:1.83E-16 ID:SGTC_521|Compound:r062-0005|FD-Score:3.16|P-value:9.20E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.99|P-value:3.53E-19 ID:SGTC_558|Compound:k064-0027|FD-Score:-4.25|P-value:1.35E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.14|P-value:9.44E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.21|P-value:7.58E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-4.00|P-value:3.76E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.82|P-value:7.81E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:-4.43|P-value:5.95E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.75|P-value:1.03E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.45|P-value:3.24E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.02|P-value:3.69E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:3.90|P-value:6.01E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.43|P-value:5.87E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.95|P-value:5.00E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.76|P-value:6.63E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.81|P-value:8.36E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.23|P-value:1.49E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-4.46|P-value:5.07E-6 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.36|P-value:8.00E-6 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.42|P-value:6.21E-6 ID:SGTC_1521|Compound:st012942|FD-Score:-3.97|P-value:4.26E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.57|P-value:2.16E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.16|P-value:1.75E-7 ID:SGTC_2010|Compound:4012422|FD-Score:-3.94|P-value:4.81E-5 ID:SGTC_2301|Compound:7769476|FD-Score:3.17|P-value:9.00E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_2427|Compound:5545055|FD-Score:4.01|P-value:3.80E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.00|P-value:4.08E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:3.58|P-value:2.07E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.78|P-value:9.87E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.11|P-value:8.29E-10 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.04|P-value:3.36E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.00|P-value:3.76E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.45|P-value:3.18E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.75|P-value:1.37E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.94|P-value:5.06E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.84|P-value:7.36E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.74|P-value:1.36E-6 ID:SGTC_3291|Compound:9121177|FD-Score:-3.23|P-value:7.05E-4

Top fitness defect scores for YDR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 8.99 172.0 µM 3.53E-19 calcium & mitochondrial duress 52 1.21E-19
2 SGTC_2616 abietic acid 6.11 100.0 µM 8.29E-10 11 4.97E-10
3 SGTC_1241 0364-0022 5.76 50.8 µM 6.63E-9 ERG2 8 4.19E-9
4 SGTC_1801 st050089 5.16 28.4 µM 1.75E-7 NEO1-PIK1 68 1.21E-7
5 SGTC_951 1171-0579 5.02 82.7 µM 3.69E-7 cell wall 45 2.59E-7
6 SGTC_2963 9082507 4.75 9.0 µM 1.37E-6 14 9.96E-7
7 SGTC_1262 0737-0114 4.23 49.6 µM 1.49E-5 16 1.15E-5
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.21 3.7 µM 1.62E-5 67 1.25E-5
9 SGTC_2622 2-methoxyxanthone 4.04 59.9 µM 3.36E-5 18 2.65E-5
10 SGTC_2427 5545055 4.01 42.8 µM 3.80E-5 12 3.00E-5
11 SGTC_2436 5633522 4.00 8.1 µM 4.08E-5 15 3.23E-5
12 SGTC_1122 capsaicin 3.95 818.6 nM 5.00E-5 28 3.97E-5
13 SGTC_3209 9113616 3.94 49.5 µM 5.06E-5 25 4.03E-5
14 SGTC_1078 idebenone 3.90 36.1 µM 6.01E-5 Golgi 46 4.80E-5
15 SGTC_2608 thymoquinone 3.78 42.7 µM 9.87E-5 20 7.99E-5
16 SGTC_741 4582-0002 3.72 126.0 µM 1.22E-4 15 9.93E-5
17 SGTC_2429 5902844 3.60 64.4 µM 1.92E-4 36 1.58E-4
18 SGTC_2607 solasodine 3.58 47.4 µM 2.07E-4 70 1.71E-4
19 SGTC_6 0844-0013 3.57 19.8 µM 2.14E-4 130 1.77E-4
20 SGTC_1779 st039427 3.57 55.0 µM 2.16E-4 41 1.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.330 1.15E-85 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.255 1.19E-50 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.176 9.92E-25 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.176 1.30E-24 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.170 4.15E-23 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.160 1.30E-20 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.160 1.55E-20 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.153 4.99E-19 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.150 3.01E-18 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.148 6.01E-18 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.147 1.57E-17 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.145 2.75E-17 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.144 5.68E-17 YOR043W WHI2 hom Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
0.142 1.18E-16 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.142 1.97E-16 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C