14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR099W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.199 | 2.56E-31 | YGL081W_p | YGL081W_p | hom | Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis |
0.180 | 9.26E-26 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
0.175 | 1.29E-24 | YJL135W_d | YJL135W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 |
0.171 | 2.14E-23 | YJR019C | TES1 | hom | Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids |
0.165 | 5.46E-22 | YBL086C_p | YBL086C_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
0.163 | 1.76E-21 | YML084W_d | YML084W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.157 | 7.83E-20 | YDL110C | TMA17 | hom | Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion |
0.150 | 3.05E-18 | YLR205C | HMX1 | hom | ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants |
0.146 | 1.66E-17 | YDR122W | KIN1 | hom | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p |
0.146 | 1.84E-17 | YPL264C_p | YPL264C_p | hom | Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene |
0.145 | 3.71E-17 | YGR025W_d | YGR025W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.138 | 9.89E-16 | YOR012W_p | YOR012W_p | hom | Putative protein of unknown function |
0.136 | 2.74E-15 | YKL205W | LOS1 | hom | Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm |
0.134 | 5.58E-15 | YLR016C | PML1 | hom | Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p |
0.132 | 1.39E-14 | YOR238W_p | YOR238W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |