YDR110W / FOB1

Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR110W / FOB1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.47|P-value:5.87E-9 ID:SGTC_12|Compound:0849-0099|FD-Score:4.94|P-value:1.30E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.19|P-value:4.14E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.03|P-value:7.82E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.19|P-value:4.24E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:5.97|P-value:2.31E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.17|P-value:6.80E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.28|P-value:2.98E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-2.96|P-value:9.65E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.99|P-value:8.58E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.83|P-value:3.11E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.36|P-value:2.22E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.75|P-value:4.67E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.82|P-value:2.30E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.57|P-value:9.32E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.40|P-value:2.20E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.96|P-value:9.62E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.02|P-value:8.09E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.41|P-value:2.01E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.09|P-value:9.98E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.60|P-value:2.52E-12 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.50|P-value:1.25E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.28|P-value:2.97E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-5.21|P-value:2.50E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.34|P-value:2.45E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.72|P-value:5.35E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.45|P-value:1.53E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.11|P-value:5.75E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.39|P-value:2.05E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-3.37|P-value:2.11E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.40|P-value:1.86E-4 ID:SGTC_2299|Compound:7976368|FD-Score:4.99|P-value:9.76E-8 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.40|P-value:8.59E-9 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.88|P-value:2.46E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.12|P-value:5.71E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.67|P-value:5.13E-7 ID:SGTC_3008|Compound:9078912|FD-Score:-3.65|P-value:6.59E-5 ID:SGTC_3130|Compound:9127414|FD-Score:-3.96|P-value:1.68E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:5.47|P-value:5.87E-9 ID:SGTC_12|Compound:0849-0099|FD-Score:4.94|P-value:1.30E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.19|P-value:4.14E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.03|P-value:7.82E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.19|P-value:4.24E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:5.97|P-value:2.31E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.17|P-value:6.80E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.28|P-value:2.98E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:-2.96|P-value:9.65E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.99|P-value:8.58E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.83|P-value:3.11E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.36|P-value:2.22E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.75|P-value:4.67E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.82|P-value:2.30E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.57|P-value:9.32E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.40|P-value:2.20E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-2.96|P-value:9.62E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.02|P-value:8.09E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.41|P-value:2.01E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.09|P-value:9.98E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.60|P-value:2.52E-12 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.50|P-value:1.25E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.28|P-value:2.97E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-5.21|P-value:2.50E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.35|P-value:2.43E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.34|P-value:2.45E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.72|P-value:5.35E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.45|P-value:1.53E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.11|P-value:5.75E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.39|P-value:2.05E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-3.37|P-value:2.11E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.40|P-value:1.86E-4 ID:SGTC_2299|Compound:7976368|FD-Score:4.99|P-value:9.76E-8 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.40|P-value:8.59E-9 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.88|P-value:2.46E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.12|P-value:5.71E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.67|P-value:5.13E-7 ID:SGTC_3008|Compound:9078912|FD-Score:-3.65|P-value:6.59E-5 ID:SGTC_3130|Compound:9127414|FD-Score:-3.96|P-value:1.68E-5

Top fitness defect scores for YDR110W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_371 0195-0006 5.97 7.4 µM 2.31E-10 4 1.17E-9
2 SGTC_8 0354-0001 5.47 70.0 µM 5.87E-9 33 2.30E-8
3 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 5.40 63.6 µM 8.59E-9 19 3.26E-8
4 SGTC_2299 7976368 4.99 114.9 µM 9.76E-8 14 3.05E-7
5 SGTC_12 0849-0099 4.94 9.3 µM 1.30E-7 10 3.98E-7
6 SGTC_807 1315-0151 4.40 48.0 µM 2.20E-6 15 5.37E-6
7 SGTC_453 enantio-paf c16 4.17 10.0 µM 6.80E-6 127 1.52E-5
8 SGTC_1083 didemethylchlorpromazine sulfoxide 4.09 707.4 nM 9.98E-6 redox potentiating 73 2.16E-5
9 SGTC_716 1683-5115 3.75 658.0 µM 4.67E-5 24 8.96E-5
10 SGTC_1630 st005209 3.72 31.3 µM 5.35E-5 28 1.02E-4
11 SGTC_612 0302-0167 3.51 22.4 µM 1.26E-4 copper-dependent oxidative stress 56 2.25E-4
12 SGTC_2103 5378138 3.39 10.0 µM 2.05E-4 36 3.51E-4
13 SGTC_1263 0774-1208 3.35 64.8 µM 2.43E-4 76 4.11E-4
14 SGTC_1360 1598-0022 3.34 39.8 µM 2.45E-4 ERG2 56 4.13E-4
15 SGTC_2608 thymoquinone 3.12 42.7 µM 5.71E-4 46 9.03E-4
16 SGTC_163 1327-0036 3.03 7.5 µM 7.82E-4 180 0.00121
17 SGTC_1079 idarubicin 3.02 2.4 µM 8.09E-4 DNA damage response 47 0.00125
18 SGTC_130 0136-0219 2.92 337.7 µM 0.00119 73 0.00178
19 SGTC_457 grayanotoxin iii 2.84 135.0 µM 0.00154 158 0.00226
20 SGTC_694 1315-0438 2.77 43.2 µM 0.00193 52 0.00278

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.246 2.05E-47 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.231 8.41E-42 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.225 7.60E-40 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.220 5.26E-38 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.214 6.07E-36 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.199 2.59E-31 YLR267W_p BOP2_p hom Protein of unknown function
0.199 2.76E-31 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.195 6.32E-30 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.191 6.85E-29 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.188 3.88E-28 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.186 1.30E-27 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.185 3.24E-27 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.180 6.07E-26 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.180 8.37E-26 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.177 6.61E-25 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity